Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules

Sussman, Michael R.; Shohet, J. Leon; Choudhury, Faraz A.; Blatz, Joshua M.; Minkoff, Benjamin B.; Benjamin, Daniel I.

Title: Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules

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Abstract

This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.

Inventors:: Sussman, Michael R.; Shohet, J. Leon; Choudhury, Faraz A.; Blatz, Joshua M.; Minkoff, Benjamin B.; Benjamin, Daniel I.

Issue Date:: 2020-02-25

Research Org.:: Wisconsin Alumni Research Foundation, Madison, WI (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1632612

Patent Number(s):: 10571460

Application Number:: 15/600,352

Assignee:: Wisconsin Alumni Research Foundation (Madison, WI)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/0031 - {Step by step routines describing the use of the apparatus

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2333/90216 - acting on a heme group of donors
G01N2333/765 - Serum albumin, e.g. HSA
G01N1/28 - Preparing specimens for investigation {including physical details of
G01N2440/00 - Post-translational modifications [PTMs] in chemical analysis of biological material

H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
H05H1/24 - Generating plasma {

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/487 - of liquid biological material

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/0894 - Processes carried out in the presence of a plasma
B01J19/088 - {giving rise to electric discharges

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/6848 - {Methods of protein analysis involving mass spectrometry}
G01N2333/91215 - with a definite EC number

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/50 - Chemical analysis of biological material, e.g. blood, urine

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/0809 - employing two or more electrodes

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DOE Contract Number:: FG02-88ER13938

Resource Type:: Patent

Resource Relation:: Patent File Date: 05/19/2017

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Sussman, Michael R., Shohet, J. Leon, Choudhury, Faraz A., Blatz, Joshua M., Minkoff, Benjamin B., and Benjamin, Daniel I. Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules.  United States: N. p., 2020. 
        Web.

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                    Sussman, Michael R., Shohet, J. Leon, Choudhury, Faraz A., Blatz, Joshua M., Minkoff, Benjamin B., & Benjamin, Daniel I. Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules.  United States.

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                    Sussman, Michael R., Shohet, J. Leon, Choudhury, Faraz A., Blatz, Joshua M., Minkoff, Benjamin B., and Benjamin, Daniel I. Tue .  
        "Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules".  United States.  https://www.osti.gov/servlets/purl/1632612.

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@article{osti_1632612,

  title        = {Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules},

  author       = {Sussman, Michael R. and Shohet, J. Leon and Choudhury, Faraz A. and Blatz, Joshua M. and Minkoff, Benjamin B. and Benjamin, Daniel I.},

  abstractNote = {This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2020},

  month        = {2}

}

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