Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II ##STR00001## have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.

Inventors:: Makriyannis, Alexandros; Shukla, Vidyanand G.; Alapafuja, Shakiru O.

Issue Date:: 2020-02-25

Research Org.:: Northeastern Univ., Boston, MA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1632602

Patent Number(s):: 10570146

Application Number:: 15/328,428

Assignee:: Northeastern University (Boston, MA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D403/14 - containing three or more hetero rings
C07D213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D491/107 - with only one oxygen atom as ring hetero atom in the oxygen-containing ring
C07D411/12 - linked by a chain containing hetero atoms as chain links
C07D403/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D401/12 - linked by a chain containing hetero atoms as chain links
C07D213/64 - attached in position 2 or 6
C07D257/04 - Five-membered rings
C07D241/04 - having no double bonds between ring members or between ring members and non-ring members
C07D215/04 - with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
C07D405/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D233/61 - with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
C07D205/04 - having no double bonds between ring members or between ring members and non-ring members
C07D471/08 - Bridged systems
C07D487/08 - Bridged systems
C07D211/16 - with acylated ring nitrogen atom
C07D215/12 - with substituted hydrocarbon radicals attached to ring carbon atoms
C07D213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
C07D211/46 - having a hydrogen atom as the second substituent in position 4
C07D213/84 - Nitriles
C07D211/54 - Sulfur atoms
C07D295/195 - Radicals derived from nitrogen analogues of carboxylic acids
C07D213/85 - in position 3
C07D401/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D401/14 - containing three or more hetero rings
C07D295/26 - Sulfur atoms
C07D295/14 - substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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DOE Contract Number:: FG02-00ER45852

Resource Type:: Patent

Resource Relation:: Patent File Date: 07/24/2015

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof.  United States: N. p., 2020. 
        Web.

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                    Makriyannis, Alexandros, Shukla, Vidyanand G., & Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof.  United States.

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                    Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Tue .  
        "Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof".  United States.  https://www.osti.gov/servlets/purl/1632602.

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@article{osti_1632602,

  title        = {Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof},

  author       = {Makriyannis, Alexandros and Shukla, Vidyanand G. and Alapafuja, Shakiru O.},

  abstractNote = {Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II ##STR00001## have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2020},

  month        = {2}

}

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Works referenced in this record:

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
patent, November 1991

Taylor, Jr., Chandler R.; Cale. Jr., Albert D.; Johnson, David N.
US Patent Document 5,068,231
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5068231

Azetidine derivatives as FAAH inhibitors
patent, May 2013

Roughley, Stephen; Walls, Steven; Hart, Terance W.
US Patent Document 8,450,346
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=8450346

Substituted triazole derivatives as oxytocin antagonists
patent, July 2009

Brown, Alan Daniel; Calabrese, Andrew Antony; Ellis, David
US Patent Document 7,557,131
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7557131

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Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Citation Formats

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides patent, November 1991

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