Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Makriyannis, Alexandros; Shukla, Vidyanand G.; Alapafuja, Shakiru O.

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Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II ##STR00001## have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.

Inventors:: Makriyannis, Alexandros; Shukla, Vidyanand G.; Alapafuja, Shakiru O.

Issue Date:: Tue Feb 25 00:00:00 EST 2020

Research Org.:: Northeastern Univ., Boston, MA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1632602

Patent Number(s):: 10570146

Application Number:: 15/328,428

Assignee:: Northeastern University (Boston, MA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D205/04 - having no double bonds between ring members or between ring members and non-ring members
C07D211/16 - with acylated ring nitrogen atom
C07D211/46 - having a hydrogen atom as the second substituent in position 4
C07D211/54 - Sulfur atoms
C07D213/64 - attached in position 2 or 6
C07D213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
C07D213/84 - Nitriles
C07D213/85 - in position 3
C07D215/04 - with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
C07D215/12 - with substituted hydrocarbon radicals attached to ring carbon atoms
C07D233/61 - with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
C07D241/04 - having no double bonds between ring members or between ring members and non-ring members
C07D257/04 - Five-membered rings
C07D295/14 - substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D295/195 - Radicals derived from nitrogen analogues of carboxylic acids
C07D295/26 - Sulfur atoms
C07D401/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D401/12 - linked by a chain containing hetero atoms as chain links
C07D401/14 - containing three or more hetero rings
C07D403/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D403/14 - containing three or more hetero rings
C07D405/06 - linked by a carbon chain containing only aliphatic carbon atoms
C07D411/12 - linked by a chain containing hetero atoms as chain links
C07D471/08 - Bridged systems
C07D487/08 - Bridged systems
C07D491/107 - with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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DOE Contract Number:: FG02-00ER45852

Resource Type:: Patent

Resource Relation:: Patent File Date: 07/24/2015

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof.  United States: N. p., 2020. 
        Web.

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                    Makriyannis, Alexandros, Shukla, Vidyanand G., & Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof.  United States.

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                    Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Tue .  
        "Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof".  United States.  https://www.osti.gov/servlets/purl/1632602.

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@article{osti_1632602,

  title        = {Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof},

  author       = {Makriyannis, Alexandros and Shukla, Vidyanand G. and Alapafuja, Shakiru O.},

  abstractNote = {Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II ##STR00001## have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Feb 25 00:00:00 EST 2020},

  month        = {Tue Feb 25 00:00:00 EST 2020}

}

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Works referenced in this record:

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
patent, November 1991

Taylor, Jr., Chandler R.; Cale. Jr., Albert D.; Johnson, David
US Patent Document 5,068,231
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5068231

Azetidine Ring Compounds and Drugs Comprising the Same
patent-application, June 2007

Habashita, Hiromu; Kurata, Haruto; Nakade, Shinji
US Patent Application 10/584435; 20070135402
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070135402

Heteroaryl-Substituted Urea Modulators of Fatty Acid Amide Hydrolase
patent-application, March 2009

Apodaca, Richard; Breitenbucher, J. Guy; Hawryluk, Natalie A.
US Patent Application 12/126389; 20090062294
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090062294

Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
patent-application, June 2013

Pearson, James Philip; Milne, Todd G.; Johnston, Thomas Henry
US Patent Application 13/520644; 20130150346
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130150346

Fatty Acid Amide Hydrolase Inhibitors from Virtual Screening of the Endocannabinoid System
journal, June 2006

Saario, Susanna M.; Poso, Antti; Juvonen, Risto O.
Journal of Medicinal Chemistry, Vol. 49, Issue 15
https://doi.org/10.1021/jm060394q

Azetidine derivatives as FAAH inhibitors
patent, May 2013

Roughley, Stephen; Walls, Steven; Hart, Terance
US Patent Document 8,450,346
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8450346

Methods, Compositions, and Compounds for Modulation of Monoacylglycerol Lipase, Pain and Stress-Related Disorders
patent-application, March 2009

Piomelli, Danielle; Duranti, Andrea; Tontini, Andrea
US Patent Application 11/912386; 20090082435
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090082435

Substituted triazole derivatives as oxytocin antagonists
patent, July 2009

Brown, Alan Daniel; Calabrese, Andrew Antony; Ellis, David
US Patent Document 7,557,131
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7557131

Heteroaryl Substituted Urea Modulators of Fatty Acid Amide Hydrolase
patent-application, March 2014

Breitenbucher, J. Guy; Keith, John M.; Tichenor, Mark S.
US Patent Application 14/072835; 20140066412
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140066412

Monoacylglcerol Lipase Inhibitors for Modulation of Cannabinoid Activity
patent-application, February 2011

Makriyannis, Alexandros; Nikas, Spyridon P.; Alapafuja, Shakidru O.
US Patent Application 12/761980; 20110039874
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110039874

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Similar Records

Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Citation Formats

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides patent, November 1991

Azetidine Ring Compounds and Drugs Comprising the Same patent-application, June 2007

Heteroaryl-Substituted Urea Modulators of Fatty Acid Amide Hydrolase patent-application, March 2009

Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome patent-application, June 2013

Fatty Acid Amide Hydrolase Inhibitors from Virtual Screening of the Endocannabinoid System journal, June 2006

Azetidine derivatives as FAAH inhibitors patent, May 2013

Methods, Compositions, and Compounds for Modulation of Monoacylglycerol Lipase, Pain and Stress-Related Disorders patent-application, March 2009

Substituted triazole derivatives as oxytocin antagonists patent, July 2009

Heteroaryl Substituted Urea Modulators of Fatty Acid Amide Hydrolase patent-application, March 2014

Monoacylglcerol Lipase Inhibitors for Modulation of Cannabinoid Activity patent-application, February 2011

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
patent, November 1991

Azetidine Ring Compounds and Drugs Comprising the Same
patent-application, June 2007

Heteroaryl-Substituted Urea Modulators of Fatty Acid Amide Hydrolase
patent-application, March 2009

Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
patent-application, June 2013

Fatty Acid Amide Hydrolase Inhibitors from Virtual Screening of the Endocannabinoid System
journal, June 2006

Azetidine derivatives as FAAH inhibitors
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Methods, Compositions, and Compounds for Modulation of Monoacylglycerol Lipase, Pain and Stress-Related Disorders
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Substituted triazole derivatives as oxytocin antagonists
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Heteroaryl Substituted Urea Modulators of Fatty Acid Amide Hydrolase
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