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Title: Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof

Abstract

Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II ##STR00001## have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.

Inventors:
; ;
Issue Date:
Research Org.:
Northeastern Univ., Boston, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1632602
Patent Number(s):
10570146
Application Number:
15/328,428
Assignee:
Northeastern University (Boston, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
FG02-00ER45852
Resource Type:
Patent
Resource Relation:
Patent File Date: 07/24/2015
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof. United States: N. p., 2020. Web.
Makriyannis, Alexandros, Shukla, Vidyanand G., & Alapafuja, Shakiru O. Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof. United States.
Makriyannis, Alexandros, Shukla, Vidyanand G., and Alapafuja, Shakiru O. Tue . "Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof". United States. https://www.osti.gov/servlets/purl/1632602.
@article{osti_1632602,
title = {Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof},
author = {Makriyannis, Alexandros and Shukla, Vidyanand G. and Alapafuja, Shakiru O.},
abstractNote = {Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II ##STR00001## have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {2}
}

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Works referenced in this record:

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
patent, November 1991


Azetidine derivatives as FAAH inhibitors
patent, May 2013


Substituted triazole derivatives as oxytocin antagonists
patent, July 2009