Method for producing thorium-226

Title: Method for producing thorium-226

Abstract

Disclosed herein are embodiments of a method for producing thorium-226. The method comprises separating thorium-226 from uranium-230 to produce a solution of thorium-226 in a solvent, such as a chelating buffer, suitable for direct labeling by a chelate. The thorium-226 may be separated from the uranium-230 using extraction chromatography. The extraction may be repeated multiple times as additional thorium-226 is produced by uranium-230 decay.

Inventors:: Fassbender, Michael E.; Mastren, Tara E.

Issue Date:: 2020-02-18

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1632561

Patent Number(s):: 10562835

Application Number:: 15/954,924

Assignee:: Triad National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C51/418 - {Preparation of metal complexes containing carboxylic acid moieties}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D59/30 - by ion exchange

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G2001/0094 - {Other isotopes not provided for in the groups listed above}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J39/05 - in the strongly acidic form

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D15/26 - characterised by the separation mechanism
B01D15/362 - {Cation-exchange}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J39/19 - obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/0005 - {Isotope delivery systems

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D59/24 - by solvent extraction

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DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 04/17/2018

Country of Publication:: United States

Language:: English

Citation Formats


                    Fassbender, Michael E., and Mastren, Tara E. Method for producing thorium-226.  United States: N. p., 2020. 
        Web.

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                    Fassbender, Michael E., & Mastren, Tara E. Method for producing thorium-226.  United States.

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                    Fassbender, Michael E., and Mastren, Tara E. Tue .  
        "Method for producing thorium-226".  United States.  https://www.osti.gov/servlets/purl/1632561.

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@article{osti_1632561,

  title        = {Method for producing thorium-226},

  author       = {Fassbender, Michael E. and Mastren, Tara E.},

  abstractNote = {Disclosed herein are embodiments of a method for producing thorium-226. The method comprises separating thorium-226 from uranium-230 to produce a solution of thorium-226 in a solvent, such as a chelating buffer, suitable for direct labeling by a chelate. The thorium-226 may be separated from the uranium-230 using extraction chromatography. The extraction may be repeated multiple times as additional thorium-226 is produced by uranium-230 decay.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2020},

  month        = {2}

}

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Works referenced in this record:

Radionuclides for medical use
patent, September 2010

Morgenstern, Alfred; Apostolidis, Christos; Molinet, Roger
US Patent Document 7,794,691
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7794691

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Title: Method for producing thorium-226

Abstract

Citation Formats

Radionuclides for medical use patent, September 2010

Radionuclides for medical use
patent, September 2010