Yeast host cells and methods for producing fatty alcohols
Abstract
The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1632540
- Patent Number(s):
- 10557152
- Application Number:
- 15/979,144
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/14/2018
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 09 BIOMASS FUELS
Citation Formats
D'Espaux, Leopold, and Keasling, Jay D. Yeast host cells and methods for producing fatty alcohols. United States: N. p., 2020.
Web.
D'Espaux, Leopold, & Keasling, Jay D. Yeast host cells and methods for producing fatty alcohols. United States.
D'Espaux, Leopold, and Keasling, Jay D. Tue .
"Yeast host cells and methods for producing fatty alcohols". United States. https://www.osti.gov/servlets/purl/1632540.
@article{osti_1632540,
title = {Yeast host cells and methods for producing fatty alcohols},
author = {D'Espaux, Leopold and Keasling, Jay D.},
abstractNote = {The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {2}
}
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Works referenced in this record:
Yeast Strains and Method for the Production of Omega-Hydroxy Fatty Acids and Dicarboxylic Acids
patent-application, October 2016
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patent-application, July 2016
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Engineering Of Hydrocarbon Metabolism In Yeast
patent-application, August 2016
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