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Title: Metal oxide nanoparticle for cell lysis

Abstract

A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1632402
Patent Number(s):
10525146
Application Number:
16/385,519
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 04/16/2019
Country of Publication:
United States
Language:
English

Citation Formats

Rajh, Tijana, Rozhkova, Elena A., Fry, Harry C., Dimitrijevic, Nada, Koritarov, Tamara, and Gryzbowski, Bartosz. Metal oxide nanoparticle for cell lysis. United States: N. p., 2020. Web.
Rajh, Tijana, Rozhkova, Elena A., Fry, Harry C., Dimitrijevic, Nada, Koritarov, Tamara, & Gryzbowski, Bartosz. Metal oxide nanoparticle for cell lysis. United States.
Rajh, Tijana, Rozhkova, Elena A., Fry, Harry C., Dimitrijevic, Nada, Koritarov, Tamara, and Gryzbowski, Bartosz. Tue . "Metal oxide nanoparticle for cell lysis". United States. https://www.osti.gov/servlets/purl/1632402.
@article{osti_1632402,
title = {Metal oxide nanoparticle for cell lysis},
author = {Rajh, Tijana and Rozhkova, Elena A. and Fry, Harry C. and Dimitrijevic, Nada and Koritarov, Tamara and Gryzbowski, Bartosz},
abstractNote = {A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {1}
}

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