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Title: Solution target for cyclotron production of radiometals

Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Inventors:
; ;
Issue Date:
Research Org.:
Mayo Foundation for Medical Education and Research, Rochester, MN (United States); Brigham and Women's Hospital, Inc., Boston, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600451
Patent Number(s):
10522261
Application Number:
15/311,052
Assignee:
Mayo Foundation for Medical Education and Research (Rochester, MN); Brigham and Women's Hospital, Inc. (Boston, MA)
Patent Classifications (CPCs):
H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
DOE Contract Number:  
SC0008947
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/15/2015
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

DeGrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Solution target for cyclotron production of radiometals. United States: N. p., 2019. Web.
DeGrado, Timothy R., Pandey, Mukesh K., & Byrne, John. Solution target for cyclotron production of radiometals. United States.
DeGrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Tue . "Solution target for cyclotron production of radiometals". United States. https://www.osti.gov/servlets/purl/1600451.
@article{osti_1600451,
title = {Solution target for cyclotron production of radiometals},
author = {DeGrado, Timothy R. and Pandey, Mukesh K. and Byrne, John},
abstractNote = {Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}

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Works referenced in this record:

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Biomedical silver-109m isotope generator
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Process for producing yttrium-90-labelled protein substrate
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