Self-replication of nucleic acid origami tiles
Abstract
The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.
- Inventors:
- Issue Date:
- Research Org.:
- New York Univ. (NYU), NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1600419
- Patent Number(s):
- 10513535
- Application Number:
- 14/923,361
- Assignee:
- New York University (New York, NY)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- SC0007991
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/26/2015
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Self-replication of nucleic acid origami tiles. United States: N. p., 2019.
Web.
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, & Seeman, Nadrian C. Self-replication of nucleic acid origami tiles. United States.
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Tue .
"Self-replication of nucleic acid origami tiles". United States. https://www.osti.gov/servlets/purl/1600419.
@article{osti_1600419,
title = {Self-replication of nucleic acid origami tiles},
author = {He, Xiaojing and Sha, Ruojie and Mi, Yongli and Chaikin, Paul and Seeman, Nadrian C.},
abstractNote = {The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}
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