Self-replication of nucleic acid origami tiles

Title: Self-replication of nucleic acid origami tiles

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Abstract

The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.

Inventors:: He, Xiaojing; Sha, Ruojie; Mi, Yongli; Chaikin, Paul; Seeman, Nadrian C.

Issue Date:: 2019-12-24

Research Org.:: New York Univ. (NYU), NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1600419

Patent Number(s):: 10513535

Application Number:: 14/923,361

Assignee:: New York University (New York, NY)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q2565/113 - based on agglutination/precipitation

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C07H21/04 - with deoxyribosyl as saccharide radical

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6816 - characterised by the detection means

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/11 - DNA or RNA fragments

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DOE Contract Number:: SC0007991

Resource Type:: Patent

Resource Relation:: Patent File Date: 10/26/2015

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Self-replication of nucleic acid origami tiles.  United States: N. p., 2019. 
        Web.

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                    He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, & Seeman, Nadrian C. Self-replication of nucleic acid origami tiles.  United States.

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                    He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Tue .  
        "Self-replication of nucleic acid origami tiles".  United States.  https://www.osti.gov/servlets/purl/1600419.

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@article{osti_1600419,

  title        = {Self-replication of nucleic acid origami tiles},

  author       = {He, Xiaojing and Sha, Ruojie and Mi, Yongli and Chaikin, Paul and Seeman, Nadrian C.},

  abstractNote = {The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {12}

}

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