DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Self-replication of nucleic acid origami tiles

Abstract

The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
New York Univ. (NYU), NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600419
Patent Number(s):
10513535
Application Number:
14/923,361
Assignee:
New York University (New York, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
SC0007991
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/26/2015
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Self-replication of nucleic acid origami tiles. United States: N. p., 2019. Web.
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, & Seeman, Nadrian C. Self-replication of nucleic acid origami tiles. United States.
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Tue . "Self-replication of nucleic acid origami tiles". United States. https://www.osti.gov/servlets/purl/1600419.
@article{osti_1600419,
title = {Self-replication of nucleic acid origami tiles},
author = {He, Xiaojing and Sha, Ruojie and Mi, Yongli and Chaikin, Paul and Seeman, Nadrian C.},
abstractNote = {The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}

Works referenced in this record:

DNA Self‐Assembly of Targeted Near‐Infrared‐Responsive Gold Nanoparticles for Cancer Thermo‐Chemotherapy
journal, October 2012


An information-bearing seed for nucleating algorithmic self-assembly
journal, March 2009


Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing
journal, February 2007


Molecular computation of solutions to combinatorial problems
journal, November 1994


Self-Sustained Replication of an RNA Enzyme
journal, February 2009


Folding DNA to create nanoscale shapes and patterns
journal, March 2006


DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties
journal, September 2012


A New Modular Approach to Nanoassembly: Stable and Addressable DNA Nanoconstructs via Orthogonal Click Chemistries
journal, September 2012


Wavelength-Selective, IR Light-Driven Hinges Based on Liquid Crystalline Elastomer Composites
journal, March 2013


Controlled release of an anti-cancer drug from DNA structured nano-films
journal, February 2014


The world's smallest assembly line
journal, January 2012


Self-replication of information-bearing nanoscale patterns
journal, October 2011