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Title: Self-replication of nucleic acid origami tiles

Abstract

The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
New York Univ., New York, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600419
Patent Number(s):
10,513,535
Application Number:
14/923,361
Assignee:
New York University (New York, NY)
DOE Contract Number:  
SC0007991
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/26/2015
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Self-replication of nucleic acid origami tiles. United States: N. p., 2019. Web.
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, & Seeman, Nadrian C. Self-replication of nucleic acid origami tiles. United States.
He, Xiaojing, Sha, Ruojie, Mi, Yongli, Chaikin, Paul, and Seeman, Nadrian C. Tue . "Self-replication of nucleic acid origami tiles". United States. https://www.osti.gov/servlets/purl/1600419.
@article{osti_1600419,
title = {Self-replication of nucleic acid origami tiles},
author = {He, Xiaojing and Sha, Ruojie and Mi, Yongli and Chaikin, Paul and Seeman, Nadrian C.},
abstractNote = {The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}

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