Hybrid polyketide synthases
Abstract
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1600351
- Patent Number(s):
- 10494625
- Application Number:
- 15/144,727
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/02/2016
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Fortman, Jeffrey L., Hagen, Andrew, Katz, Leonard, Keasling, Jay D., Poust, Sean, Zhang, Jingwei, and Zotchev, Sergey. Hybrid polyketide synthases. United States: N. p., 2019.
Web.
Fortman, Jeffrey L., Hagen, Andrew, Katz, Leonard, Keasling, Jay D., Poust, Sean, Zhang, Jingwei, & Zotchev, Sergey. Hybrid polyketide synthases. United States.
Fortman, Jeffrey L., Hagen, Andrew, Katz, Leonard, Keasling, Jay D., Poust, Sean, Zhang, Jingwei, and Zotchev, Sergey. Tue .
"Hybrid polyketide synthases". United States. https://www.osti.gov/servlets/purl/1600351.
@article{osti_1600351,
title = {Hybrid polyketide synthases},
author = {Fortman, Jeffrey L. and Hagen, Andrew and Katz, Leonard and Keasling, Jay D. and Poust, Sean and Zhang, Jingwei and Zotchev, Sergey},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}
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