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Title: Hybrid polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600351
Patent Number(s):
10494625
Application Number:
15/144,727
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 05/02/2016
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Fortman, Jeffrey L., Hagen, Andrew, Katz, Leonard, Keasling, Jay D., Poust, Sean, Zhang, Jingwei, and Zotchev, Sergey. Hybrid polyketide synthases. United States: N. p., 2019. Web.
Fortman, Jeffrey L., Hagen, Andrew, Katz, Leonard, Keasling, Jay D., Poust, Sean, Zhang, Jingwei, & Zotchev, Sergey. Hybrid polyketide synthases. United States.
Fortman, Jeffrey L., Hagen, Andrew, Katz, Leonard, Keasling, Jay D., Poust, Sean, Zhang, Jingwei, and Zotchev, Sergey. Tue . "Hybrid polyketide synthases". United States. https://www.osti.gov/servlets/purl/1600351.
@article{osti_1600351,
title = {Hybrid polyketide synthases},
author = {Fortman, Jeffrey L. and Hagen, Andrew and Katz, Leonard and Keasling, Jay D. and Poust, Sean and Zhang, Jingwei and Zotchev, Sergey},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}

Patent:

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