Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette

Van Dam, R. Michael; Moore, Melissa; Maraglia, Brandon; Thompson, Daniel

Title: Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette

Abstract

A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.

Inventors:: Van Dam, R. Michael; Moore, Melissa; Maraglia, Brandon; Thompson, Daniel

Issue Date:: 2019-11-12

Research Org.:: Univ. of California, Oakland, CA (United States); Sofie Biosciences, Inc., Culver City, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1600275

Patent Number(s):: 10473668

Application Number:: 15/315,369

Assignee:: The Regents of the University of California (Oakland, CA); Sofie Biosciences, Inc. (Culver City, CA)

Patent Classifications (CPCs):: G - PHYSICS G21 - NUCLEAR PHYSICS G21H - OBTAINING ENERGY FROM RADIOACTIVE SOURCES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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G - PHYSICS G21 - NUCLEAR PHYSICS G21H - OBTAINING ENERGY FROM RADIOACTIVE SOURCES
G21H5/02 - as tracers

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B6/542 - {involving control of exposure}

G - PHYSICS G21 - NUCLEAR PHYSICS G21F - PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT
G21F5/015 - for storing radioactive sources, e.g. source carriers for irradiation units

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/60 - involving radioactive labelled substances

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B59/00 - Introduction of isotopes of elements into organic compounds {

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B6/037 - {Emission tomography
A61B6/48 - {Diagnostic techniques

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/0005 - {Isotope delivery systems

Show less

DOE Contract Number:: SC0006238

Resource Type:: Patent

Resource Relation:: Patent File Date: 06/05/2015

Country of Publication:: United States

Language:: English

Subject:: 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats


                    Van Dam, R. Michael, Moore, Melissa, Maraglia, Brandon, and Thompson, Daniel. Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette.  United States: N. p., 2019. 
        Web.

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                    Van Dam, R. Michael, Moore, Melissa, Maraglia, Brandon, & Thompson, Daniel. Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette.  United States.

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                    Van Dam, R. Michael, Moore, Melissa, Maraglia, Brandon, and Thompson, Daniel. Tue .  
        "Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette".  United States.  https://www.osti.gov/servlets/purl/1600275.

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@article{osti_1600275,

  title        = {Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette},

  author       = {Van Dam, R. Michael and Moore, Melissa and Maraglia, Brandon and Thompson, Daniel},

  abstractNote = {A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {11}

}

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Title: Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette

Abstract

Citation Formats

Digital microfluidic platform for radiochemistry patent, April 2015

Perfusion hyperthermia treatment system and method patent, July 2002

Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography patent, November 2010

Microwave assisted chemical processes patent, October 1999

Microfluidic Radiosynthesis System For Positron Emission Tomography Biomarkers patent-application, February 2009

Microfluidic Platform For Cell Culture And Assay patent-application, June 2011

Digital microfluidic platform for radiochemistry patent, November 2016

Device for synthesis of radiopharmaceutical products patent-application, February 2004

Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography patent, December 2011

System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices patent, June 2010

Modular radiochemistry synthesis system patent, November 2016

System and Method for Processing Chemical Substances, Computer Program for Controlling Such System, and a Corresponding Computer-Readable Storage Medium patent-application, September 2008

Microfluidic handling system patent, October 2016

Disposable world-to-chip interface for digital microfluidics patent, May 2017

Digital microfluidic platform for radiochemistry patent, November 2015

Microfluidic radiosynthesis system for positron emission tomography biomarkers patent, December 2011

Fluid Interface Cartridge For A Microfluidic Chip patent-application, January 2011

Actuators for microfluidics without moving parts patent, May 2003

Modular radiochemistry synthesis system patent, December 2015

Microfluidic chemical reaction circuits patent, June 2012

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Biomolecule labeling reaction container, and reactor and reaction method using the same patent, August 2016

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Method for preparing [18F]fallypride with low base concentration patent, January 2014

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Dose synthesis module for biomarker generator system patent, December 2012

Modular radiochemistry synthesis system patent, February 2015

Portable microfluidic radiosynthesis system for positron emission tomography biomarkers and program code patent, May 2012

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Digital microfluidic platform for radiochemistry
patent, April 2015

Perfusion hyperthermia treatment system and method
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Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
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Microfluidic Radiosynthesis System For Positron Emission Tomography Biomarkers
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Digital microfluidic platform for radiochemistry
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Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
patent, December 2011

System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices
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Modular radiochemistry synthesis system
patent, November 2016

System and Method for Processing Chemical Substances, Computer Program for Controlling Such System, and a Corresponding Computer-Readable Storage Medium
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Microfluidic handling system
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Disposable world-to-chip interface for digital microfluidics
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Digital microfluidic platform for radiochemistry
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Microfluidic radiosynthesis system for positron emission tomography biomarkers
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Fluid Interface Cartridge For A Microfluidic Chip
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Method and system for forming a film of material using plasmon assisted chemical reactions
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