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Title: Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette

Abstract

A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States); Sofie Biosciences, Inc., Culver City, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600275
Patent Number(s):
10473668
Application Number:
15/315,369
Assignee:
The Regents of the University of California (Oakland, CA); Sofie Biosciences, Inc. (Culver City, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
DOE Contract Number:  
SC0006238
Resource Type:
Patent
Resource Relation:
Patent File Date: 06/05/2015
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats

Van Dam, R. Michael, Moore, Melissa, Maraglia, Brandon, and Thompson, Daniel. Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette. United States: N. p., 2019. Web.
Van Dam, R. Michael, Moore, Melissa, Maraglia, Brandon, & Thompson, Daniel. Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette. United States.
Van Dam, R. Michael, Moore, Melissa, Maraglia, Brandon, and Thompson, Daniel. Tue . "Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette". United States. https://www.osti.gov/servlets/purl/1600275.
@article{osti_1600275,
title = {Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette},
author = {Van Dam, R. Michael and Moore, Melissa and Maraglia, Brandon and Thompson, Daniel},
abstractNote = {A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {11}
}

Works referenced in this record:

Microfluidic radiosynthesis system for positron emission tomography biomarkers
patent, December 2011


Enzyme Quantification
patent-application, October 2012


Synthesis of 2'-Deoxy-2'-[¹⁸F]Fluoro-5-Methyl-1-B-D-Arabinofuranosyluracil (¹⁸F-FMAU)
patent-application, March 2012


Method for Preparing [¹⁸F]fallypride with Low Base Concentration
patent-application, July 2012


Disposable Module for Device for Synthesizing Radioisotopes and Process for Manufacturing Said Module
patent-application, March 2015


Microfluidics for Positron Emission Tomography Probe Development
journal, July 2010


Microfluidic Radiosynthesis of a Radiolabeled Compound Using Electrochemical Trapping and Release
patent-application, April 2009


Microfluidic Radiosynthesis System For Positron Emission Tomography Biomarkers
patent-application, February 2009


Microfluidic chemical reaction circuits
patent, June 2012


Disposable world-to-chip interface for digital microfluidics
patent, May 2017


An Automated, Multi-Pot High-Pressure Radio-Synthesizer for Production of Pet Tracers
patent-application, September 2016


Radiopharmacy and Devices
patent-application, December 2013


Process and Apparatus for Production of F-18 Fluoride
patent-application, October 2003


Modular radiochemistry synthesis system
patent, February 2015


Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
journal, January 2003

  • Alauddin, Mian M.; Fissekis, John D.; Conti, Peter S.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, Issue 9, p. 805-814
  • https://doi.org/10.1002/jlcr.712

Digital Microfluidic Platform for Radiochemistry
patent-application, July 2015


Droplet-Based Washing
patent-application, October 2007


Automation for Optimised Production of Fluorine-18-Labelled Radiopharmaceuticals
journal, July 2010


Positron Emission Tomography (PET) and Microfluidic Devices: A Breakthrough on the Microscale?
journal, March 2007


Modular radiochemistry synthesis system
patent, December 2015


Device for Material Purification
patent-application, September 2013


Digital Microfluidic Platform for Radiochemistry
patent-application, October 2012


Insert Assembly for a Microfluidic Device
patent-application, May 2014


System for Radiopharmaceutical Preparation Involving Solid and Liquid Phase Interactions
patent-application, January 2013


Modular Radiochemistry Synthesis System
patent-application, May 2012


Methods and Apparatus for Flow-Controlled Wetting
patent-application, July 2014


Synthesis of [18F]-labeled 2?-deoxy-2?-fluoro-5-methyl-1-?-D-arabinofuranosyluracil ([18F]-FMAU)
journal, January 2002

  • Alauddin, Mian M.; Conti, Peter S.; Fissekis, John D.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 45, Issue 7
  • https://doi.org/10.1002/jlcr.549

System and Method for Controlling a Microfluidic Handling Device
patent-application, June 2014


Modular Radiochemistry Synthesis System
patent-application, May 2016


Microfluidic Handling System
patent-application, July 2013


Disposable World-to-Chip Interface for Digital Microfluidics
patent-application, May 2015


Soft printing of droplets pre-metered by electrowetting
journal, September 2004


Rapid Multi-Material Sample Input System
patent-application, November 2003


Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
journal, May 2010


Very high pressure HPLC with 1 mm id columns
journal, April 2004


Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals-full
patent-application, April 2013


Microfluidic Platform For Cell Culture And Assay
patent-application, June 2011


Microfluidic Chip and a Related Method Thereof
patent-application, May 2013


System for Purification and Analysis of Radiochemical Products Yielded by Microfluidic Synthesis Devices
patent-application, March 2008


Method for Synthesizing [¹⁸F]SFB Using Microsynthesis Technique
patent-application, February 2012


Arrangement for Automatic Handling of Radioactive Materials
patent-application, December 2012


World-to-Digital-Microfluidic Interface Enabling Extraction and Purification of RNA from Human Whole Blood
journal, February 2014


Portable apparatus for separating sample and detecting target analytes
patent, November 2008


Plug-and-play modules for flexible radiosynthesis
journal, August 2013


Device for synthesis of radiopharmaceutical products
patent-application, February 2004


Method, System, and Sub-System, for Processing a Chemical Reaction
patent-application, February 2004


Fluid Interface Cartridge For A Microfluidic Chip
patent-application, January 2011


Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
patent, November 2010


Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer
journal, January 2011


Fully-Automated Microfluidic System for the Synthesis of Radiolabeled Biomarkers for Positron Emission Tomography
patent-application, September 2008


Microfluidic handling system
patent, October 2016


Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis
journal, February 2010


Microfluidic Apparatus and Method for Synthesis of Molecular Imaging Probes Including FDG
patent-application, October 2005


Microfluidic Pump and Valve Structures and Fabrication Methods
patent-application, March 2009


Peristaltic Micropump
patent-application, June 2005


Electrochemical Phase Transfer Devices and Methods
patent-application, June 2012


Microfluidic Chemical Reaction Circuits
patent-application, November 2008


Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure
patent-application, January 2011


A fully automated synthesis of [ 18 F]-FEAU and [ 18 F]-FMAU using a novel dual reactor radiosynthesis module
journal, November 2009


A retrospective on the automation of laboratory synthetic chemistry
journal, October 1992


Systems, Methods and Apparatus for Manufacturing Radioisotopes
patent-application, March 2015


Perfusion hyperthermia treatment system and method
patent, July 2002


Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer
journal, January 2013


Apparatus and Method Using Rotary Flow Distribution Mechanisms
patent-application, May 2010


Microfluidic Reactor Having an Annular Reaction Chamber
patent-application, March 2012


On-demand droplet loading for automated organic chemistry on digital microfluidics
journal, January 2013


Digital microfluidic platform for radiochemistry
patent, November 2015


Method of Deprotection
patent-application, March 2008


Radiopharmaceutical Production System and Quality Control System Utilizing High Performance Liquid Chromatography
patent-application, May 2013


Quality Control Module for Biomarker Generator System
patent-application, March 2011


Microchip, Microchip Device and Evaporation Method Using Microchip
patent-application, September 2010


Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips
journal, January 2012


Apparatus and Method for Producing Radiopharmaceuticals
patent-application, November 2006


Microwave assisted chemical processes
patent, October 1999


Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure
patent-application, June 2011


Device for Quantification of Radioisotope Concentrations in a Micro-Fluidic Platform
patent-application, December 2009


Digital microfluidic platform for radiochemistry
patent, April 2015


Microwave Heating System
patent-application, August 2006


Micro-chemical synthesis of molecular probes on an electronic microfluidic device
journal, December 2011


Nanogenerator
patent-application, November 2011


Dose Synthesis Card for Use with Automated Biomarker Production System
patent-application, June 2015


Method and Device for Manufacturing of Radiopharmaceuticals
patent-application, May 2012


System and Method for Radiosynthesis, Quality Control and Dose Dispensing
patent-application, January 2016


Introduction
journal, December 2011


Low Power Integrated Pumping and Valving Arrays for Microfluidic Systems
patent-application, March 2003


Microchip HPLC of Peptides and Proteins
journal, May 2005


Method for Multi-Batch Production of FDG
patent-application, February 2004


Polymer Monoliths for Solvent Exchange in Continuous Flow Microfluidic Device
patent-application, June 2015


Modular radiochemistry synthesis system
patent, November 2016


System and Method for Interfacing with a Microfluidic Chip
patent-application, June 2008


EWOD Driving of Droplet on NxM Grid using Single-Layer Electrode Patterns
conference, June 2002


Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences
journal, October 2010


Use of Microfabricated Devices
patent-application, October 2005


Disposabel Radiochemistry Device with Radiation Dose Recordal
patent-application, October 2015


Dose synthesis module for biomarker generator system
patent, December 2012


A World-to-Chip Interface for Digital Microfluidics
journal, February 2009


Digital microfluidic platform for radiochemistry
patent, November 2016


Fluid Transport in Microfluidic Applications
patent-application, July 2015


Quality Control Devices and Methods for Radiopharmaceuticals
patent-application, December 2013


Systems and Methods for Reagent Storage
patent-application, July 2015


Method and Apparatus for Monitoring Radiopharmaceutical Processing
patent-application, February 2013


Dried Blood Spot Analysis by Digital Microfluidics Coupled to Nanoelectrospray Ionization Mass Spectrometry
journal, March 2012


Intuitive Graphical User Interface for Carrying out Chemical Reactions
patent-application, August 2011


Semiautomated Radiosynthesis and Biological Evaluation of [18F]FEAU: A Novel PET Imaging Agent for HSV1-tk/sr39tk Reporter Gene Expression
journal, December 2007


Modular Radiochemistry Synthesis System
patent-application, November 2015


Microreactors for radiopharmaceutical synthesis
journal, January 2009


System for Controlling Environment in a Reaction Box
patent-application, January 2015


Solid-State Beta Detector for Microfluidic Devices
patent-application, December 2004


Nucleophilic Radiofluorination Using Microfabricated Devices
patent-application, December 2009


Biomarker Generator System
patent-application, March 2008


Method for preparing [18F]fallypride with low base concentration
patent, January 2014


Method and system for forming a film of material using plasmon assisted chemical reactions
patent-application, October 2005


Microfluidic Apparatus and Method for Synthesis of Molecular Imaging Probes
patent-application, October 2005


Accurate and Rapid Micromixer for Integrated Microfluidic Devices
patent-application, May 2011


Apparatus for Synthesis of Radiolabeled Compounds
patent-application, July 2005


Modular Cassette Synthesis Unit
patent-application, January 2013


System and method for synthesis of molecular imaging probes including FDG
patent-application, December 2004


Synthesis of Diverse Tracers on ewod Microdevice for Positron Emission Tomography (Pet)
conference, May 2012


Digital Microfluidic Platform for Radiochemistry
patent-application, April 2016


Systems for Integrated Radiopharmaceutical Generation, Preparation, Transportation and Administration
patent-application, July 2011


Devices and Methods for Microfluidic Chromatography
patent-application, June 2007