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Title: Microorganisms and methods for the production of fatty acids and fatty acid derived products

Abstract

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.

Inventors:
; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Cargill, Inc., Wayzata, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600243
Patent Number(s):
10465213
Application Number:
15/083,924
Assignee:
Cargill, Incorporated (Wayzata, MN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AR0000088
Resource Type:
Patent
Resource Relation:
Patent File Date: 03/29/2016
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Liao, Hans, Spindler, Eileen, Warner, Joseph R., Louie, Michael, Ribble, Wendy, Prather, Brittany, Evans, Ron, Lipscomb, Tanya E. W., and Lynch, Michael D. Microorganisms and methods for the production of fatty acids and fatty acid derived products. United States: N. p., 2019. Web.
Liao, Hans, Spindler, Eileen, Warner, Joseph R., Louie, Michael, Ribble, Wendy, Prather, Brittany, Evans, Ron, Lipscomb, Tanya E. W., & Lynch, Michael D. Microorganisms and methods for the production of fatty acids and fatty acid derived products. United States.
Liao, Hans, Spindler, Eileen, Warner, Joseph R., Louie, Michael, Ribble, Wendy, Prather, Brittany, Evans, Ron, Lipscomb, Tanya E. W., and Lynch, Michael D. Tue . "Microorganisms and methods for the production of fatty acids and fatty acid derived products". United States. https://www.osti.gov/servlets/purl/1600243.
@article{osti_1600243,
title = {Microorganisms and methods for the production of fatty acids and fatty acid derived products},
author = {Liao, Hans and Spindler, Eileen and Warner, Joseph R. and Louie, Michael and Ribble, Wendy and Prather, Brittany and Evans, Ron and Lipscomb, Tanya E. W. and Lynch, Michael D.},
abstractNote = {This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {11}
}

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Materials and Methods for the Efficient Production of Acetate and Other Products
patent-application, June 2009


Production of Fatty Acid Derivatives
patent-application, March 2011


Spacing of the -10 and -35 regions in the tac promoter. Effect on its in vivo activity.
journal, March 1985


Process For Producing Optically Active 3-hydroxypropionic Ester Derivative
patent-application, July 2006


Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster
journal, March 2005


Methods, Systems And Compositions For Increased Microorganism Tolerance To And Production Of 3-Hydroxypropionic Acid (3-HP)
patent-application, October 2012


A new preparation of trifluoromethanesulfinate salts
journal, July 2007


Process for the Biological Production of 3-Hydroxypropionic Acid with High Yield
patent-application, June 2011


Method for producing target substance by fermentation
patent, August 2006


Catalyzed esterification process
patent, June 1995


Method for producing an organic acid
patent, December 2011


Treatment of biomass to obtain fermentable sugars
patent-application, February 2007


Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide
patent-application, October 2014


Production of Modified Fatty Acids in Plants
patent-application, July 2010


The IdhA Gene Encoding the Fermentative Lactate Dehydrogenase of Escherichia Coli
journal, January 1997


Compositions Comprising and Methods for Producing Beta-Hydroxy Fatty Acid Esters
patent-application, August 2014


Regulation of fatty acid biosynthesis in Escherichia coli.
journal, January 1993


Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH.
journal, April 1992


Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase
journal, January 1988


Expression of microbial proteins in plants for production of plants with improved properties
patent-application, December 2003


Production Of Isoprenoids
patent-application, November 2008


Methods and Compositions for Producing Chemical Products from C. Phytofermentans
patent-application, July 2011


Extracellular Polyhydroxyalkanoates Produced By Genetically Engineered Microorganisms
patent-application, July 2011


Method For Determining Gene Knockouts
patent-application, January 2004


Genetic Modification for Production of 3-Hydroxypropionic Acid
patent-application, December 2012


Carboxylic acid recovery and methods related thereto
patent-application, November 2011


Development Of Sensitive Fret Sensors And Methods Of Using The Same
patent-application, February 2010


Cloning, crystallization and preliminary characterization of a β-carbonic anhydrase from Escherichia coli
journal, September 2000


Higher Fatty Acid Triester and Amide Derivative Having Diethylenetriamine-Type Metal Chelate Structure
patent-application, October 2009


Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
journal, June 2003


Method for the Production of Resveratrol in a Recombinant Oleaginous Microorganism
patent-application, March 2009


Method of Enhanced Bioproduction
patent-application, February 2015


Methods of making amino acids using E. coli transformed with csc genes
patent, November 2005


The commercial production of chemicals using pathway engineering
journal, December 2000


3-hydroxypropionic acid and other organic compounds
patent, December 2009


Engineering of Thermotolerant Bacillus Coagulans for Production of D(-)-Lactic Acid
patent-application, May 2012


Selective production of L-aspartic acid and L-phenylalanine by coupling reactions of aspartase and aminotransferase in Escherichia coli
journal, July 2000


Electroporation of Alcaligenes eutrophus with (mega) plasmids and genomic DNA fragments
journal, October 1994


Energy Efficient Methods To Produce Products
patent-application, August 2008


A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length
journal, August 2007


The Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of Escherichia coli Acetyl-CoA Carboxylase
journal, June 2003


Lactic acid production, separation and/or recovery process
patent, April 1996


Method For Identifying A Biosynthetic Pathway Gene Product
patent-application, June 2007


3-Hydroxypropionic Acid and Other Organic Compounds
patent-application, September 2012


Acetyl-coA carboxylases
patent, September 2016


Method of Producing 3-Hydroxypropionic Acid Using Malonic Semialdehyde Reducing Pathway
patent-application, September 2012


Enhanced production of fatty acid derivatives
patent, February 2012


Reactions of β-lactones with potassium alkoxides and their complexes with 18-crown-6 in aprotic solvents
journal, July 1993


De novo biosynthetic pathways: rational design of microbial chemical factories
journal, October 2008


FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli
journal, November 2003


3-phenylpropionate catabolism and the Escherichia coli oxidative stress response
journal, April 2005


Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems
patent-application, October 2007


Methods Of Making Intermediates From Polyhydroxyalkanoates
patent-application, August 2003


Biosynthetic pathways for 3-hydroxypropionic acid production
journal, February 2009


A T42M Substitution in Bacterial 5-Enolpyruvylshikimate-3-phosphate Synthase (EPSPS) Generates Enzymes with Increased Resistance to Glyphosate
journal, January 2003


Process for the Biological Production of 1,3-propanediol With High Yield
patent-application, August 2004


Water-absorbing agent and production process therefor
patent, October 2001


Purification Of 3-Hydroxypropionic Acid From Crude Cell Broth And Production Of Acrylamide
patent-application, December 2013


Metabolically engineered microorganism useful for the production of 1,2-propanediol
patent-application, October 2010


3-hydroxypropionic acid and other organic compounds
patent-application, August 2007


Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli
journal, January 2008


Overproduction of a Functional Fatty Acid Biosynthetic Enzyme Blocks Fatty Acid Synthesis inEscherichia coli
journal, September 1998


Naturally Occurring Adenines within mRNA Coding Sequences Affect Ribosome Binding and Expression in Escherichia coli
journal, November 2006


Methods and compositions for directed cloning and subcloning using homologous recombination
patent, March 2002


ActRII Receptor Polypeptides, Methods And Compositions
patent-application, March 2006


Inhibiting Bacterial Fatty Acid Synthesis
journal, April 2006


Manipulating flux through plant metabolic pathways
journal, April 1998


The biological degradation of cellulose
journal, January 1994


Metabolically Engineered Organisms For Enhanced Production Of Oxaloacetate-derived Biochemicals
patent-application, May 2003


Engineering the pathway for succinate production
patent-application, March 2012


Beta-alanine synthesis in Escherichia coli.
journal, January 1980


Method for producing nucleic acid substances
patent, September 2001


Thin, flexible sanitary napkin
patent, April 1991


Dihydrolipoamide Dehydrogenase Mutation Alters the NADH Sensitivity of Pyruvate Dehydrogenase Complex of Escherichia coli K-12
journal, March 2008


Toward a science of metabolic engineering
journal, June 1991


Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis
journal, May 2003


Alanine 2, 3 Aminomutases
patent-application, January 2009


Reverse Beta Oxidation Pathway
patent-application, November 2013


Schizochytrium PKS Genes
patent-application, May 2003


Disposable diaper having density and basis weight profiled absorbent core
patent, August 1987


Light-directed, spatially addressable parallel chemical synthesis
journal, February 1991


Method for the production of &rgr;-Hydroxybenzoate in species of pseudomonas and agrobacterium
patent, July 2003


Characterization of Mutations Contributing to Sulfathiazole Resistance in Escherichia coli
journal, January 1998


Polymers for use in water treatment
patent, June 1977