Solution target for cyclotron production of radiometals

Degrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Title: Solution target for cyclotron production of radiometals

Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Inventors:: Degrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Issue Date:: 2019-10-08

Research Org.:: Mayo Foundation for Medical Education and Research, Rochester, MN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1576447

Patent Number(s):: 10438712

Application Number:: 15/493,310

Assignee:: Mayo Foundation for Medical Education and Research (Rochester, MN)

Patent Classifications (CPCs):: H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

Show more

H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
H05H6/00 - Targets for producing nuclear reactions

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J20/3092 - {Packing of a container, e.g. packing a cartridge or column

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/001 - {Recovery of specific isotopes from irradiated targets}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J20/3251 - {comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur}
B01J20/22 - comprising organic material

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D15/08 - Selective adsorption, e.g. chromatography

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J20/3085 - {Chemical treatments not covered by groups B01J20/3007 - B01J20/3078}

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G2001/0021 - {Gallium}
G21G1/10 - by bombardment with electrically charged particles

Show less

DOE Contract Number:: SC0008947

Resource Type:: Patent

Resource Relation:: Patent File Date: 2017 Apr 21

Country of Publication:: United States

Language:: English

Citation Formats


                    Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Solution target for cyclotron production of radiometals.  United States: N. p., 2019. 
        Web.

Copy to clipboard


                    Degrado, Timothy R., Pandey, Mukesh K., & Byrne, John. Solution target for cyclotron production of radiometals.  United States.

Copy to clipboard


                    Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Tue .  
        "Solution target for cyclotron production of radiometals".  United States.  https://www.osti.gov/servlets/purl/1576447.

Copy to clipboard


                    
@article{osti_1576447,

  title        = {Solution target for cyclotron production of radiometals},

  author       = {Degrado, Timothy R. and Pandey, Mukesh K. and Byrne, John},

  abstractNote = {Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {10}

}

Copy to clipboard

Patent:

View Patent

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Process for separating a radionuclide from solution
patent, April 1995

Zinn, Kurt R.
US Patent Document 5,409,677
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5409677

Concentration of perrhenate and pertechnetate solutions
patent, March 1998

Knapp, Jr., Furn F.; Beets, Arnold L.; Mirzadeh, Saed
US Patent Document 5,729,821
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5729821

Process for producing yttrium-90-labelled protein substrate
patent, May 1999

Chinol, Marco; Franceschini, Rodolfo; Lunghi, Fabio
US Patent Document 5,902,566
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5902566

Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator
patent, January 2000

Welch, Michael J.; McCarthy, Deborah W.; Shefer, Ruth E.
US Patent Document 6,011,825
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6011825

Similar Records in DOE Patents and OSTI.GOV collections:

Solution target for cyclotron production of radiometals

Patent DeGrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; amore »« less
Full Text Available
Method for fabricating .sup.99 Mo production targets using low enriched uranium, .sup.99 Mo production targets comprising low enriched uranium

Patent Wiencek, Thomas C [Orland Park, IL]; Matos, James E [Oak Park, IL]; Hofman, Gerard L [Downers Grove, IL]

A radioisotope production target and a method for fabricating a radioisotope production target is provided, wherein the target comprises an inner cylinder, a foil of fissionable material circumferentially contacting the outer surface of the inner cylinder, and an outer hollow cylinder adapted to receive the substantially foil-covered inner cylinder and compress tightly against the foil to provide good mechanical contact therewith. The method for fabricating a primary target for the production of fission products comprises preparing a first substrate to receive a foil of fissionable material so as to allow for later removal of the foil from the first substrate,more »« less
Full Text Available
Method for fabricating .sup.99 Mo production targets using low enriched uranium, .sup.99 Mo production targets comprising low enriched uranium

Patent Wiencek, Thomas C [Orland Park, IL]; Matos, James E [Oak Park, IL]; Hofman, Gerard L [Downers Grove, IL]

A radioisotope production target and a method for fabricating a radioisotope production target is provided, wherein the target comprises an inner cylinder, a foil of fissionable material circumferentially contacting the outer surface of the inner cylinder, and an outer hollow cylinder adapted to receive the substantially foil-covered inner cylinder and compress tightly against the foil to provide good mechanical contact therewith. The method for fabricating a primary target for the production of fission products comprises preparing a first substrate to receive a foil of fissionable material so as to allow for later removal of the foil from the first substrate,more »« less
Full Text Available
Production of large resonant plasma volumes in microwave electron cyclotron resonance ion sources

Patent Alton, Gerald D [Kingston, TN]

Microwave injection methods for enhancing the performance of existing electron cyclotron resonance (ECR) ion sources. The methods are based on the use of high-power diverse frequency microwaves, including variable-frequency, multiple-discrete-frequency, and broadband microwaves. The methods effect large resonant "volume" ECR regions in the ion sources. The creation of these large ECR plasma volumes permits coupling of more microwave power into the plasma, resulting in the heating of a much larger electron population to higher energies, the effect of which is to produce higher charge state distributions and much higher intensities within a particular charge state than possible in present ECRmore » ion sources.« less
Full Text Available
Ion cyclotron range of frequencies heating of plasma with small impurity production

Patent Ohkawa, Tihiro [La Jolla, CA]

Plasma including plasma ions is magnetically confined by a magnetic field. The plasma has a defined outer surface and is intersected by resonance surfaces of respective common ion cyclotron frequency of a predetermined species of plasma ions moving in the magnetic field. A radio frequency source provides radio frequency power at a radio frequency corresponding to the ion cyclotron frequency of the predetermined species of plasma ions moving in the field at a respective said resonance surface. RF launchers coupled to the radio frequency source radiate radio frequency energy at the resonance frequency onto the respective resonance surface within themore »« less
Full Text Available

Similar Records

Title: Solution target for cyclotron production of radiometals

Abstract

Citation Formats

Process for separating a radionuclide from solution patent, April 1995

Concentration of perrhenate and pertechnetate solutions patent, March 1998

Process for producing yttrium-90-labelled protein substrate patent, May 1999

Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator patent, January 2000

Process for separating a radionuclide from solution
patent, April 1995

Concentration of perrhenate and pertechnetate solutions
patent, March 1998

Process for producing yttrium-90-labelled protein substrate
patent, May 1999

Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator
patent, January 2000