Solution target for cyclotron production of radiometals

Title: Solution target for cyclotron production of radiometals

Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Inventors:: Degrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Issue Date:: 2019-10-08

Research Org.:: Mayo Foundation for Medical Education and Research, Rochester, MN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1576447

Patent Number(s):: 10438712

Application Number:: 15/493,310

Assignee:: Mayo Foundation for Medical Education and Research (Rochester, MN)

Patent Classifications (CPCs):: H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

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H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
H05H6/00 - Targets for producing nuclear reactions

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/001 - {Recovery of specific isotopes from irradiated targets}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J20/22 - comprising organic material

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D15/08 - Selective adsorption, e.g. chromatography

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G2001/0021 - {Gallium}
G21G1/10 - by bombardment with electrically charged particles

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DOE Contract Number:: SC0008947

Resource Type:: Patent

Resource Relation:: Patent File Date: 2017 Apr 21

Country of Publication:: United States

Language:: English

Citation Formats


                    Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Solution target for cyclotron production of radiometals.  United States: N. p., 2019. 
        Web.

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                    Degrado, Timothy R., Pandey, Mukesh K., & Byrne, John. Solution target for cyclotron production of radiometals.  United States.

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                    Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Tue .  
        "Solution target for cyclotron production of radiometals".  United States.  https://www.osti.gov/servlets/purl/1576447.

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@article{osti_1576447,

  title        = {Solution target for cyclotron production of radiometals},

  author       = {Degrado, Timothy R. and Pandey, Mukesh K. and Byrne, John},

  abstractNote = {Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {10}

}

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Works referenced in this record:

Process for separating a radionuclide from solution
patent, April 1995

Zinn, Kurt R.
US Patent Document 5,409,677
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5409677

Concentration of perrhenate and pertechnetate solutions
patent, March 1998

Knapp, Jr., Furn F.; Beets, Arnold L.; Mirzadeh, Saed
US Patent Document 5,729,821
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Process for producing yttrium-90-labelled protein substrate
patent, May 1999

Chinol, Marco; Franceschini, Rodolfo; Lunghi, Fabio
US Patent Document 5,902,566
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5902566

Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator
patent, January 2000

Welch, Michael J.; McCarthy, Deborah W.; Shefer, Ruth E.
US Patent Document 6,011,825
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6011825

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Title: Solution target for cyclotron production of radiometals

Abstract

Citation Formats

Process for separating a radionuclide from solution patent, April 1995

Concentration of perrhenate and pertechnetate solutions patent, March 1998

Process for producing yttrium-90-labelled protein substrate patent, May 1999

Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator patent, January 2000

Process for separating a radionuclide from solution
patent, April 1995

Concentration of perrhenate and pertechnetate solutions
patent, March 1998

Process for producing yttrium-90-labelled protein substrate
patent, May 1999

Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator
patent, January 2000