Title: Solution target for cyclotron production of radiometals

Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Inventors:

Degrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Issue Date:

2019-10-08

Research Org.:

Mayo Foundation for Medical Education and Research, Rochester, MN (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1576447

Patent Number(s):

10438712

Application Number:

15/493,310

Assignee:

Mayo Foundation for Medical Education and Research (Rochester, MN)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B01D15/08 - Selective adsorption, e.g. chromatography

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J20/22 - comprising organic material
B01J20/3085 - {Chemical treatments not covered by groups B01J20/3007 - B01J20/3078}
B01J20/3092 - {Packing of a container, e.g. packing a cartridge or column
B01J20/3251 - {comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur}

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

G21G1/001 - {Recovery of specific isotopes from irradiated targets}
G21G1/10 - by bombardment with electrically charged particles
G21G2001/0021 - {Gallium}

H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE

H05H6/00 - Targets for producing nuclear reactions

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DOE Contract Number:  

SC0008947

Resource Type:

Patent

Resource Relation:

Patent File Date: 2017 Apr 21

Country of Publication:

United States

Language:

English