Solution target for cyclotron production of radiometals
Abstract
Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
- Inventors:
- Issue Date:
- Research Org.:
- Mayo Foundation for Medical Education and Research, Rochester, MN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1576447
- Patent Number(s):
- 10438712
- Application Number:
- 15/493,310
- Assignee:
- Mayo Foundation for Medical Education and Research (Rochester, MN)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05H - PLASMA TECHNIQUE
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
- DOE Contract Number:
- SC0008947
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2017 Apr 21
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Solution target for cyclotron production of radiometals. United States: N. p., 2019.
Web.
Degrado, Timothy R., Pandey, Mukesh K., & Byrne, John. Solution target for cyclotron production of radiometals. United States.
Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Tue .
"Solution target for cyclotron production of radiometals". United States. https://www.osti.gov/servlets/purl/1576447.
@article{osti_1576447,
title = {Solution target for cyclotron production of radiometals},
author = {Degrado, Timothy R. and Pandey, Mukesh K. and Byrne, John},
abstractNote = {Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {10}
}
Works referenced in this record:
Process for separating a radionuclide from solution
patent, April 1995
- Zinn, Kurt R.
- US Patent Document 5,409,677
Concentration of perrhenate and pertechnetate solutions
patent, March 1998
- Knapp, Jr., Furn F.; Beets, Arnold L.; Mirzadeh, Saed
- US Patent Document 5,729,821
Process for producing yttrium-90-labelled protein substrate
patent, May 1999
- Chinol, Marco; Franceschini, Rodolfo; Lunghi, Fabio
- US Patent Document 5,902,566
Production of .sup.64 Cu and other radionuclides using a charged-particle accelerator
patent, January 2000
- Welch, Michael J.; McCarthy, Deborah W.; Shefer, Ruth E.
- US Patent Document 6,011,825