Solution target for cyclotron production of radiometals

Title: Solution target for cyclotron production of radiometals

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Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Inventors:: Degrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Issue Date:: 2019-10-08

Research Org.:: Mayo Foundation for Medical Education and Research, Rochester, MN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1576447

Patent Number(s):: 10,438,712

Application Number:: 15/493,310

Assignee:: Mayo Foundation for Medical Education and Research (Rochester, MN)

DOE Contract Number:: SC0008947

Resource Type:: Patent

Resource Relation:: Patent File Date: 2017 Apr 21

Country of Publication:: United States

Language:: English

Citation Formats


                    Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Solution target for cyclotron production of radiometals.  United States: N. p., 2019. 
        Web.

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                    Degrado, Timothy R., Pandey, Mukesh K., & Byrne, John. Solution target for cyclotron production of radiometals.  United States.

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                    Degrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Tue .  
        "Solution target for cyclotron production of radiometals".  United States.  https://www.osti.gov/servlets/purl/1576447.

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@article{osti_1576447,

  title        = {Solution target for cyclotron production of radiometals},

  author       = {Degrado, Timothy R. and Pandey, Mukesh K. and Byrne, John},

  abstractNote = {Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {10}

}

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