skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Compositions and methods for RNA-based antimicrobial drug targeting

Abstract

A ribonucleic acid (RNA) based modular regulatory element (MRE) for inhibiting translation of a target gene transcript in an organism (e.g. a pathogen) includes a first segment of RNA capable of forming a stem loop structure, a second segment of RNA downstream of the first segment of RNA and having a target sequence capable of binding to the target gene transcript (or polycistron lead gene transcript), and a third segment of RNA downstream of the second segment of RNA and being capable of forming a terminator hairpin downstream of the target sequence. Methods for assaying the role of a putative target gene in an organism include inhibiting expression of various target genes using the RNA-based MRE.

Inventors:
;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1576387
Patent Number(s):
10400240
Application Number:
15/884,265
Assignee:
Triad National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2018 Jan 30
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Marti-Arbona, Ricardo, and Hennelly, Scott. Compositions and methods for RNA-based antimicrobial drug targeting. United States: N. p., 2019. Web.
Marti-Arbona, Ricardo, & Hennelly, Scott. Compositions and methods for RNA-based antimicrobial drug targeting. United States.
Marti-Arbona, Ricardo, and Hennelly, Scott. Tue . "Compositions and methods for RNA-based antimicrobial drug targeting". United States. https://www.osti.gov/servlets/purl/1576387.
@article{osti_1576387,
title = {Compositions and methods for RNA-based antimicrobial drug targeting},
author = {Marti-Arbona, Ricardo and Hennelly, Scott},
abstractNote = {A ribonucleic acid (RNA) based modular regulatory element (MRE) for inhibiting translation of a target gene transcript in an organism (e.g. a pathogen) includes a first segment of RNA capable of forming a stem loop structure, a second segment of RNA downstream of the first segment of RNA and having a target sequence capable of binding to the target gene transcript (or polycistron lead gene transcript), and a third segment of RNA downstream of the second segment of RNA and being capable of forming a terminator hairpin downstream of the target sequence. Methods for assaying the role of a putative target gene in an organism include inhibiting expression of various target genes using the RNA-based MRE.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {9}
}

Patent:

Save / Share: