Non-contact temperature control system for microfluidic devices

Title: Non-contact temperature control system for microfluidic devices

Abstract

The present invention relates to a temperature control system for a microfluidic device. The system allows for non-contact heating by employing an infrared emitter. In some instances, the system can be used in conjunction with a centrifugal microfluidic device. Optionally, a mask can be implemented to provide selective heating of desired assay areas of the device.

Inventors:: Phaneuf, Christopher; Koh, Chung-Yan

Issue Date:: 2019-09-10

Research Org.:: National Technology & Engineering Solutions of Sandia, LLC, Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1576324

Patent Number(s):: 10,406,528

Application Number:: 15/669,426

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

DOE Contract Number:: NA0003525

Resource Type:: Patent

Resource Relation:: Patent File Date: 2017 Aug 04

Country of Publication:: United States

Language:: English

Citation Formats


                    Phaneuf, Christopher, and Koh, Chung-Yan. Non-contact temperature control system for microfluidic devices.  United States: N. p., 2019. 
        Web.

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                    Phaneuf, Christopher, & Koh, Chung-Yan. Non-contact temperature control system for microfluidic devices.  United States.

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                    Phaneuf, Christopher, and Koh, Chung-Yan. Tue .  
        "Non-contact temperature control system for microfluidic devices".  United States.  https://www.osti.gov/servlets/purl/1576324.

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@article{osti_1576324,

  title        = {Non-contact temperature control system for microfluidic devices},

  author       = {Phaneuf, Christopher and Koh, Chung-Yan},

  abstractNote = {The present invention relates to a temperature control system for a microfluidic device. The system allows for non-contact heating by employing an infrared emitter. In some instances, the system can be used in conjunction with a centrifugal microfluidic device. Optionally, a mask can be implemented to provide selective heating of desired assay areas of the device.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {9}

}

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A non-contact infrared thermometer measures target temperatures remotely without requiring the ratio of the target size to the target distance to the thermometer. A collection means collects and focusses target IR radiation on an IR detector. The detector measures thermal energy of the target over a spectrum using micromechanical sensors. A processor means calculates the collected thermal energy in at least two different spectral regions using a first algorithm in program form and further calculates the ratio of the thermal energy in the at least two different spectral regions to obtain the target temperature independent of the target size, distancemore »« less
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Mobile monolithic polymer elements for flow control in microfluidic devices

Patent Hasselbrink, Jr., Ernest F. (Saline, MI); Rehm, Jason E [Alameda, CA]; Shepodd, Timothy J [Livermore, CA]; ...

A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by fluid pressure (either liquid or gas) against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressuresmore »« less
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Fluid control structures in microfluidic devices

Patent Mathies, Richard A. (Moraga, CA); Grover, William H. (Berkeley, CA); Skelley, Alison (Berkeley, CA); ...

Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
Full Text Available
Mobile monolithic polymer elements for flow control in microfluidic devices

Patent Hasselbrink, Jr., Ernest F.; Rehm, Jason E.; Shepodd, Timothy J.

A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by either fluid or gas pressure against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greatermore »« less
Full Text Available
Fluid control structures in microfluidic devices

Patent Mathies, Richard A.; Grover, William H.; Skelley, Alison; ...

Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
Full Text Available

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Title: Non-contact temperature control system for microfluidic devices

Abstract

Citation Formats

Microparticle-based methods and systems and applications thereof patent-application, December 2005

Integrated planar microfluidic bioanalytical systems patent-application, August 2006

Method for Separating Cells patent-application, May 2008

Diagnostic tests and kits for Clostridium difficile patent, January 2003

Systems, Devices, and Methods For Agglutination Assays Using Sedimentation patent-application, March 2016

Method and apparatus for measuring blood constituent counts patent, July 1987

DNA purification and isolation using magnetic particles patent, January 1998

Method and Apparatus For Precise Transfer and Manipulation Of Fluids By Centrifugal and Or Capillary Forces patent-application, January 2009

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto patent, January 2007

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent-application, July 2002

Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species patent-application, October 2003

Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device patent, July 2010

Toxin Activity Assays, Devices, Methods And Systems Therefor patent-application, June 2016

System and method for detecting components of a mixture including a valving scheme for competition assays patent, July 2017

Multichannel control in microfluidics patent-application, October 2002

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, February 2015

Analytical methods and compositions patent-application, November 2002

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids patent, February 2008

Multi-parameter assays including analysis discs and methods relating thereto patent-application, October 2002

Microfluidic devices and methods patent-application, January 2003

Microfluidic Devices, Systems, And Methods For Quantifying Particles Using Centrifugal Force patent-application, December 2015

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent, November 2001

Diagnostic Analyzers With Pretreatment Carousels and Related Methods patent-application, September 2014

System and method for detecting components of a mixture including tooth elements for alignment patent, November 2016

Separation of solid and liquid components of mixtures patent, November 1978

Devices, systems, and methods for conducting sandwich assays using sedimentation patent, February 2015

Microfluidic devices, systems, and methods for quantifying particles using centrifugal force patent, November 2015

Apparatus and method for measuring white blood cell and platelet concentrations in blood patent, May 1979

Microfluidic particle-analysis systems patent-application, April 2004

Multi-parameter assays including analysis discs and methods relating thereto patent, April 2006

Separation Device patent-application, May 2010

Centrifugation Apparatus For Containers Of Biological Material patent-application, February 2011

Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces patent, December 2012

Method for separating the cellular components of blood samples patent, July 1989

Reagents for labeling biomolecules having aldehyde or ketone Moieties patent-application, September 2002

Plastic microfluidics enabling two-dimensional protein separations in proteome analysis patent-application, November 2002

Density-based cell detection system patent, March 2010

Protecting agent patent-application, August 2005

Apparatus and method for carrying out analysis of samples patent, April 1999

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent, November 2005

Systems, devices, and methods for agglutination assays using sedimentation patent, January 2016

Assay of blood or other biologic samples for target analytes patent, June 1997

Method for detecting analytes in a sample patent-application, December 2009

Toxin activity assays, devices, methods and systems therefor patent, April 2016

Centrifuge with removable core for scalable centrifugation patent-application, September 2005

Centrifugal hematology disposable patent, November 2000

Microfluidics devices and methods for performing cell based assays patent-application, August 2002

Microfluidic particle-analysis systems patent, December 2007

Centrifugal Separation System patent-application, August 2009

Heterogeneous binding assay patent, April 1987

Monolithic microfluidic concentrators and mixers patent, May 2005

Compact disk based platform for separating and detecting immunomagnetic bead labeled cells patent-application, June 2010

Devices and Method For Using Centripetal Acceleration To Drive Fluid Movement In A Microfluidics System With On-Board Informatics patent-application, December 2001

Method of separation employing magnetic particles and second medium patent, January 1994

Assay system and method for conducting assays patent, March 1999

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, April 2016

Method Of Detecting Analyte-Molecule Interactions patent-application, June 2008

Method For Isolating Nucleic Acids Comprising The Use Of Ethylene Glycol Multimers patent-application, March 2009

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device patent, November 1985

Method for separating cells patent-application, July 2003

Microparticle-based methods and systems and applications thereof
patent-application, December 2005

Integrated planar microfluidic bioanalytical systems
patent-application, August 2006

Method for Separating Cells
patent-application, May 2008

Diagnostic tests and kits for Clostridium difficile
patent, January 2003

Systems, Devices, and Methods For Agglutination Assays Using Sedimentation
patent-application, March 2016

Method and apparatus for measuring blood constituent counts
patent, July 1987

DNA purification and isolation using magnetic particles
patent, January 1998

Method and Apparatus For Precise Transfer and Manipulation Of Fluids By Centrifugal and Or Capillary Forces
patent-application, January 2009

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
patent, January 2007

Class characterization of circulating cancer cells isolated from body fluids and methods of use
patent-application, July 2002

Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
patent-application, October 2003

Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device
patent, July 2010

Toxin Activity Assays, Devices, Methods And Systems Therefor
patent-application, June 2016

System and method for detecting components of a mixture including a valving scheme for competition assays
patent, July 2017

Multichannel control in microfluidics
patent-application, October 2002

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, February 2015

Analytical methods and compositions
patent-application, November 2002

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
patent, February 2008

Multi-parameter assays including analysis discs and methods relating thereto
patent-application, October 2002

Microfluidic devices and methods
patent-application, January 2003

Microfluidic Devices, Systems, And Methods For Quantifying Particles Using Centrifugal Force
patent-application, December 2015

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
patent, November 2001

Diagnostic Analyzers With Pretreatment Carousels and Related Methods
patent-application, September 2014

System and method for detecting components of a mixture including tooth elements for alignment
patent, November 2016

Separation of solid and liquid components of mixtures
patent, November 1978

Devices, systems, and methods for conducting sandwich assays using sedimentation
patent, February 2015

Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
patent, November 2015

Apparatus and method for measuring white blood cell and platelet concentrations in blood
patent, May 1979

Microfluidic particle-analysis systems
patent-application, April 2004

Multi-parameter assays including analysis discs and methods relating thereto
patent, April 2006

Separation Device
patent-application, May 2010

Centrifugation Apparatus For Containers Of Biological Material
patent-application, February 2011

Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces
patent, December 2012

Method for separating the cellular components of blood samples
patent, July 1989

Reagents for labeling biomolecules having aldehyde or ketone Moieties
patent-application, September 2002

Plastic microfluidics enabling two-dimensional protein separations in proteome analysis
patent-application, November 2002

Density-based cell detection system
patent, March 2010

Protecting agent
patent-application, August 2005

Apparatus and method for carrying out analysis of samples
patent, April 1999

Class characterization of circulating cancer cells isolated from body fluids and methods of use
patent, November 2005

Systems, devices, and methods for agglutination assays using sedimentation
patent, January 2016

Assay of blood or other biologic samples for target analytes
patent, June 1997

Method for detecting analytes in a sample
patent-application, December 2009

Toxin activity assays, devices, methods and systems therefor
patent, April 2016

Centrifuge with removable core for scalable centrifugation
patent-application, September 2005

Centrifugal hematology disposable
patent, November 2000

Microfluidics devices and methods for performing cell based assays
patent-application, August 2002

Microfluidic particle-analysis systems
patent, December 2007

Centrifugal Separation System
patent-application, August 2009

Heterogeneous binding assay
patent, April 1987

Monolithic microfluidic concentrators and mixers
patent, May 2005

Compact disk based platform for separating and detecting immunomagnetic bead labeled cells
patent-application, June 2010

Devices and Method For Using Centripetal Acceleration To Drive Fluid Movement In A Microfluidics System With On-Board Informatics
patent-application, December 2001

Method of separation employing magnetic particles and second medium
patent, January 1994

Assay system and method for conducting assays
patent, March 1999

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, April 2016

Method Of Detecting Analyte-Molecule Interactions
patent-application, June 2008

Method For Isolating Nucleic Acids Comprising The Use Of Ethylene Glycol Multimers
patent-application, March 2009

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device
patent, November 1985

Method for separating cells
patent-application, July 2003