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Title: Rapid and continuous analyte processing in droplet microfluidic devices

Abstract

The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed.

Inventors:
; ;
Issue Date:
Research Org.:
State Univ. of New York (SUNY), Albany, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1576239
Patent Number(s):
10427160
Application Number:
15/908,453
Assignee:
The Research Foundation for The State University of New York (Albany, NY)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-06ER46323; NSF-DMR-0606282
Resource Type:
Patent
Resource Relation:
Patent File Date: 2018 Feb 28
Country of Publication:
United States
Language:
English

Citation Formats

Strey, Helmut, Kimmerling, Robert, and Bakowski, Tomasz. Rapid and continuous analyte processing in droplet microfluidic devices. United States: N. p., 2019. Web.
Strey, Helmut, Kimmerling, Robert, & Bakowski, Tomasz. Rapid and continuous analyte processing in droplet microfluidic devices. United States.
Strey, Helmut, Kimmerling, Robert, and Bakowski, Tomasz. Tue . "Rapid and continuous analyte processing in droplet microfluidic devices". United States. https://www.osti.gov/servlets/purl/1576239.
@article{osti_1576239,
title = {Rapid and continuous analyte processing in droplet microfluidic devices},
author = {Strey, Helmut and Kimmerling, Robert and Bakowski, Tomasz},
abstractNote = {The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {10}
}

Patent:

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