Rapid and continuous analyte processing in droplet microfluidic devices
Abstract
The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed.
- Inventors:
- Issue Date:
- Research Org.:
- State Univ. of New York (SUNY), Albany, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1576239
- Patent Number(s):
- 10427160
- Application Number:
- 15/908,453
- Assignee:
- The Research Foundation for The State University of New York (Albany, NY)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG02-06ER46323; NSF-DMR-0606282
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2018 Feb 28
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Strey, Helmut, Kimmerling, Robert, and Bakowski, Tomasz. Rapid and continuous analyte processing in droplet microfluidic devices. United States: N. p., 2019.
Web.
Strey, Helmut, Kimmerling, Robert, & Bakowski, Tomasz. Rapid and continuous analyte processing in droplet microfluidic devices. United States.
Strey, Helmut, Kimmerling, Robert, and Bakowski, Tomasz. Tue .
"Rapid and continuous analyte processing in droplet microfluidic devices". United States. https://www.osti.gov/servlets/purl/1576239.
@article{osti_1576239,
title = {Rapid and continuous analyte processing in droplet microfluidic devices},
author = {Strey, Helmut and Kimmerling, Robert and Bakowski, Tomasz},
abstractNote = {The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {10}
}