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Title: Engineered FGF compositions and methods of use thereof

Abstract

The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Univ. of Arkansas, Little Rock, AR (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568736
Patent Number(s):
10385113
Application Number:
15/474,268
Assignee:
The Board of Trustees of the University of Arkansas (Little Rock, AR)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-01ER15161
Resource Type:
Patent
Resource Relation:
Patent File Date: 03/30/2017
Country of Publication:
United States
Language:
English

Citation Formats

Thallapuranam, Suresh Kumar, Zaharoff, David A., Jayanthi, Srinivas, Koppolu, Bhanuprasanth, Kerr, Rebecca, Balachandran, Kartik, and McNabb, David S. Engineered FGF compositions and methods of use thereof. United States: N. p., 2019. Web.
Thallapuranam, Suresh Kumar, Zaharoff, David A., Jayanthi, Srinivas, Koppolu, Bhanuprasanth, Kerr, Rebecca, Balachandran, Kartik, & McNabb, David S. Engineered FGF compositions and methods of use thereof. United States.
Thallapuranam, Suresh Kumar, Zaharoff, David A., Jayanthi, Srinivas, Koppolu, Bhanuprasanth, Kerr, Rebecca, Balachandran, Kartik, and McNabb, David S. Tue . "Engineered FGF compositions and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1568736.
@article{osti_1568736,
title = {Engineered FGF compositions and methods of use thereof},
author = {Thallapuranam, Suresh Kumar and Zaharoff, David A. and Jayanthi, Srinivas and Koppolu, Bhanuprasanth and Kerr, Rebecca and Balachandran, Kartik and McNabb, David S.},
abstractNote = {The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {8}
}

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Works referenced in this record:

Chimeric fibroblast growth factor 21 proteins and methods of use
patent, March 2018


Compositions, methods and kits relating to thrombin degradation resistant fibroblast growth factor-1
patent, January 2006


Chimeric fibroblast growth factor 21 proteins and methods of use
patent, October 2016


Engineered human acidic fibroblast growth factors and associated methods
patent, September 2010