Engineered FGF compositions and methods of use thereof
Abstract
The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Arkansas, Little Rock, AR (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1568736
- Patent Number(s):
- 10385113
- Application Number:
- 15/474,268
- Assignee:
- The Board of Trustees of the University of Arkansas (Little Rock, AR)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- FG02-01ER15161
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 03/30/2017
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Thallapuranam, Suresh Kumar, Zaharoff, David A., Jayanthi, Srinivas, Koppolu, Bhanuprasanth, Kerr, Rebecca, Balachandran, Kartik, and McNabb, David S. Engineered FGF compositions and methods of use thereof. United States: N. p., 2019.
Web.
Thallapuranam, Suresh Kumar, Zaharoff, David A., Jayanthi, Srinivas, Koppolu, Bhanuprasanth, Kerr, Rebecca, Balachandran, Kartik, & McNabb, David S. Engineered FGF compositions and methods of use thereof. United States.
Thallapuranam, Suresh Kumar, Zaharoff, David A., Jayanthi, Srinivas, Koppolu, Bhanuprasanth, Kerr, Rebecca, Balachandran, Kartik, and McNabb, David S. Tue .
"Engineered FGF compositions and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1568736.
@article{osti_1568736,
title = {Engineered FGF compositions and methods of use thereof},
author = {Thallapuranam, Suresh Kumar and Zaharoff, David A. and Jayanthi, Srinivas and Koppolu, Bhanuprasanth and Kerr, Rebecca and Balachandran, Kartik and McNabb, David S.},
abstractNote = {The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {8}
}
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