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Title: Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds

Abstract

The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the β-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and β-oxidation enzymes POX1, POX2, and POX3).

Inventors:
;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568694
Patent Number(s):
10,370,686
Application Number:
15/005,719
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 01/25/2016
Country of Publication:
United States
Language:
English

Citation Formats

Runguphan, Weerawat, and Keasling, Jay D. Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds. United States: N. p., 2019. Web.
Runguphan, Weerawat, & Keasling, Jay D. Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds. United States.
Runguphan, Weerawat, and Keasling, Jay D. Tue . "Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds". United States. https://www.osti.gov/servlets/purl/1568694.
@article{osti_1568694,
title = {Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds},
author = {Runguphan, Weerawat and Keasling, Jay D.},
abstractNote = {The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the β-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and β-oxidation enzymes POX1, POX2, and POX3).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {8}
}

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