Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds
Abstract
The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the β-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and β-oxidation enzymes POX1, POX2, and POX3).
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1568694
- Patent Number(s):
- 10370686
- Application Number:
- 15/005,719
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 01/25/2016
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Runguphan, Weerawat, and Keasling, Jay D. Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds. United States: N. p., 2019.
Web.
Runguphan, Weerawat, & Keasling, Jay D. Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds. United States.
Runguphan, Weerawat, and Keasling, Jay D. Tue .
"Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds". United States. https://www.osti.gov/servlets/purl/1568694.
@article{osti_1568694,
title = {Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds},
author = {Runguphan, Weerawat and Keasling, Jay D.},
abstractNote = {The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the β-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and β-oxidation enzymes POX1, POX2, and POX3).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 06 00:00:00 EDT 2019},
month = {Tue Aug 06 00:00:00 EDT 2019}
}
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Works referenced in this record:
Production of Fatty Acids & Derivatives Thereof
patent-application, June 2012
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Production of Biodiesel by Yeast from Lignocellulose and Glycerol
patent-application, May 2013
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- US Patent Application 13/704776; 20130137149
Methods and Products for Production of Wax Esters (U.S. National Phase)
patent-application, August 2013
- Nielsen, Jens; Shi, Shuobo
- US Patent Application 13/814694; 20130197248