Conformable actively multiplexed high-density surface electrode array for brain interfacing

Rogers, John A.; Kim, Dae-Hyeong; Litt, Brian; Viventi, Jonathan

Title: Conformable actively multiplexed high-density surface electrode array for brain interfacing

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Abstract

Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveforms over large brain surface areas by any of the devices disclosed herein.

Inventors:: Rogers, John A.; Kim, Dae-Hyeong; Litt, Brian; Viventi, Jonathan

Issue Date:: 2019-07-16

Research Org.:: Univ. of Illinois at Urbana-Champaign, IL (United States); Univ. of Pennsylvania, Philadelphia, PA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1568589

Patent Number(s):: 10349860

Application Number:: 14/532,687

Assignee:: The Board of Trustees of the University of Illinois (Urbana, IL); The Trustees of the University of Pennsylvania (Philadelphia, PA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/0036 - {including treatment, e.g., using an implantable medical device, ablating, ventilating}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A61M5/31 - Details

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N1/0531 - {Brain cortex electrodes}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A61M5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/7246 - {using correlation, e.g. template matching or determination of similarity}

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
G16H50/70 - for mining of medical data, e.g. analysing previous cases of other patients

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N1/36025 - {for treating a mental or cerebral condition}
A61N5/0601 - {Apparatus for use inside the body}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A61F2/72 - Bioelectrical control, e.g. myoelectric

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/6868 - {Brain}
A61B2562/164 - the sensor is mounted in or on a conformable substrate or carrier
A61B2562/125 - characterised by the manufacture of electrodes
A61B2562/046 - in a matrix array

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N1/0529 - {Electrodes for brain stimulation}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/4094 - {Diagnosing or monitoring seizure diseases, e.g. epilepsy}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N1/36017 - {with leads or electrodes penetrating the skin}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/7282 - {Event detection, e.g. detecting unique waveforms indicative of a medical condition
A61B5/7267 - {involving training the classification device}
A61B5/4836 - {Diagnosis combined with treatment in closed-loop systems or methods

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N2005/063 - {comprising light transmitting means, e.g. optical fibres}

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DOE Contract Number:: FG02-07ER46471

Resource Type:: Patent

Resource Relation:: Patent File Date: 11/04/2014

Country of Publication:: United States

Language:: English

Citation Formats


                    Rogers, John A., Kim, Dae-Hyeong, Litt, Brian, and Viventi, Jonathan. Conformable actively multiplexed high-density surface electrode array for brain interfacing.  United States: N. p., 2019. 
        Web.

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                    Rogers, John A., Kim, Dae-Hyeong, Litt, Brian, & Viventi, Jonathan. Conformable actively multiplexed high-density surface electrode array for brain interfacing.  United States.

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                    Rogers, John A., Kim, Dae-Hyeong, Litt, Brian, and Viventi, Jonathan. Tue .  
        "Conformable actively multiplexed high-density surface electrode array for brain interfacing".  United States.  https://www.osti.gov/servlets/purl/1568589.

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@article{osti_1568589,

  title        = {Conformable actively multiplexed high-density surface electrode array for brain interfacing},

  author       = {Rogers, John A. and Kim, Dae-Hyeong and Litt, Brian and Viventi, Jonathan},

  abstractNote = {Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveforms over large brain surface areas by any of the devices disclosed herein.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {7}

}

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