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Title: Enzymes for producing non-straight-chain fatty acids

Abstract

Enzymes for producing non-straight-chain fatty acids, microorganisms comprising the enzymes, and in vivo and in vitro uses of the enzymes. Provided are enzymes capable of producing various non-straight-chain fatty acids, including branched-chain fatty acids, cyclic fatty acids, and furan-containing fatty acids. The enzymes include RSP2144, RSP1091, and RSP1090 from Rhodobacter sphaeroides and homologs thereof. The enzymes can be purified to produce non-straight-chain fatty acids in vitro or expressed in microorganisms to produce non-straight-chain fatty acids in vivo. The microorganisms can be fine-tuned to produce a specific type of non-straight-chain fatty acid by expressing, overexpressing, or deleting the enzymes in various combinations.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Wisconsin Alumni Research Foundation, Madison, WI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568261
Patent Number(s):
10273511
Application Number:
14/755,213
Assignee:
Wisconsin Alumni Research Foundation (Madison, WI)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FC02-07ER64494
Resource Type:
Patent
Resource Relation:
Patent File Date: 06/30/2015
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Lemke, Rachelle A. S., Donohue, Timothy James, Coon, Joshua J., Peterson, Amelia C., and Westphall, Michael S. Enzymes for producing non-straight-chain fatty acids. United States: N. p., 2019. Web.
Lemke, Rachelle A. S., Donohue, Timothy James, Coon, Joshua J., Peterson, Amelia C., & Westphall, Michael S. Enzymes for producing non-straight-chain fatty acids. United States.
Lemke, Rachelle A. S., Donohue, Timothy James, Coon, Joshua J., Peterson, Amelia C., and Westphall, Michael S. Tue . "Enzymes for producing non-straight-chain fatty acids". United States. https://www.osti.gov/servlets/purl/1568261.
@article{osti_1568261,
title = {Enzymes for producing non-straight-chain fatty acids},
author = {Lemke, Rachelle A. S. and Donohue, Timothy James and Coon, Joshua J. and Peterson, Amelia C. and Westphall, Michael S.},
abstractNote = {Enzymes for producing non-straight-chain fatty acids, microorganisms comprising the enzymes, and in vivo and in vitro uses of the enzymes. Provided are enzymes capable of producing various non-straight-chain fatty acids, including branched-chain fatty acids, cyclic fatty acids, and furan-containing fatty acids. The enzymes include RSP2144, RSP1091, and RSP1090 from Rhodobacter sphaeroides and homologs thereof. The enzymes can be purified to produce non-straight-chain fatty acids in vitro or expressed in microorganisms to produce non-straight-chain fatty acids in vivo. The microorganisms can be fine-tuned to produce a specific type of non-straight-chain fatty acid by expressing, overexpressing, or deleting the enzymes in various combinations.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {4}
}

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