Peptides whose uptake by cells is controllable

Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Inventors:: Jiang, Tao; Olson, Emilia S.; Whitney, Michael; Tsien, Roger

Issue Date:: 2019-04-16

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1568195

Patent Number(s):: 10,259,845

Application Number:: 14/753,975

Assignee:: The Regents of the University of California (Oakland, CA)

DOE Contract Number:: DK54441; FG03-01ER63276; GM54038; NS27177

Resource Type:: Patent

Resource Relation:: Patent File Date: 06/29/2015

Country of Publication:: United States

Language:: English

Citation Formats


                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Peptides whose uptake by cells is controllable.  United States: N. p., 2019. 
        Web.

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                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, & Tsien, Roger. Peptides whose uptake by cells is controllable.  United States.

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                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Tue .  
        "Peptides whose uptake by cells is controllable".  United States.  https://www.osti.gov/servlets/purl/1568195.

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@article{osti_1568195,

  title        = {Peptides whose uptake by cells is controllable},

  author       = {Jiang, Tao and Olson, Emilia S. and Whitney, Michael and Tsien, Roger},

  abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {4}

}

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