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Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568195
Patent Number(s):
10,259,845
Application Number:
14/753,975
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
DK54441; FG03-01ER63276; GM54038; NS27177
Resource Type:
Patent
Resource Relation:
Patent File Date: 06/29/2015
Country of Publication:
United States
Language:
English

Citation Formats

Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Peptides whose uptake by cells is controllable. United States: N. p., 2019. Web.
Jiang, Tao, Olson, Emilia S., Whitney, Michael, & Tsien, Roger. Peptides whose uptake by cells is controllable. United States.
Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Tue . "Peptides whose uptake by cells is controllable". United States. https://www.osti.gov/servlets/purl/1568195.
@article{osti_1568195,
title = {Peptides whose uptake by cells is controllable},
author = {Jiang, Tao and Olson, Emilia S. and Whitney, Michael and Tsien, Roger},
abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {4}
}

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Works referenced in this record:

Peptides whose uptake by cells is controllable
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Peptides whose uptake in cells is controllable
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Peptides whose uptake in cells is controllable
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