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Title: Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap

Abstract

Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.

Inventors:
;
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1532114
Patent Number(s):
8815177
Application Number:
12/812,974
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009-01-21
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS

Citation Formats

Perroud, Thomas D., and Patel, Kamlesh D. Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap. United States: N. p., 2014. Web.
Perroud, Thomas D., & Patel, Kamlesh D. Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap. United States.
Perroud, Thomas D., and Patel, Kamlesh D. Tue . "Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap". United States. https://www.osti.gov/servlets/purl/1532114.
@article{osti_1532114,
title = {Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap},
author = {Perroud, Thomas D. and Patel, Kamlesh D.},
abstractNote = {Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}

Works referenced in this record:

Processing of particles
patent-application, November 2004


Microscale Electrochemical Cell And Methods Incorporating The Cell
patent-application, July 2008


Apparatus and method for trapping bead based reagents within microfluidic analysis systems
patent, December 2007


Fabrication of ultra-shallow channels for microfluidic devices and systems
patent-application, September 2003


Apparatus and method for trapping bead based reagents within microfluidic analysis systems
patent-application, November 2003


Apparatus and methods for electrochemical processing of microfeature wafers
patent-application, July 2008


Wet chemical processing chambers for processing microfeature workpieces
patent-application, March 2005


Particle packing of microdevice
patent, July 2006


Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
patent-application, March 2006


Adjustable nanopore, nanotome, and nanotweezer
patent, March 2004


Integrated system with modular microfluidic components
patent, July 2007


Particulate processing system
patent, May 2007


Microfluidic devices comprising biochannels
patent-application, January 2005


Microfluidic flow control device
patent-application, December 2002


Semiconductor device and method of fabricating the same
patent-application, January 2006


Microfluidic Device and Method of Using Same
patent-application, June 2008


Methods and compositions for selecting cells with increased potency
patent-application, October 2006


Method and apparatus for separation of particles in a microfluidic device
patent, August 2006


Microfluidic system and methods of use
patent, October 2003


Apparatus and method for trapping bead based reagents within microfluidic analysis systems
patent, August 2002


Method and apparatus for entry and storage of specimens into a microfluidic devic
patent-application, December 2004


Microfluidic devices
patent-application, October 2007


Heteroduplex tracking assay
patent-application, January 2008


Polymorphic markers of the LSR gene
patent, October 2006


Microfluidic Devices
patent-application, January 2008


Device and method for contacting picoliter volumes of fluid
patent-application, May 2007


Composite polymer microfluidic control device
patent, November 2007


Microscale electrochemical cell and methods incorporating the cell
patent-application, July 2007


Methods and Apparatus for the Manipulation of Particle Suspensions and Testing Thereof
patent-application, October 2007


Fluid control structures in microfluidic devices
patent-application, October 2004


Method for sorting particles
patent, December 2004


Microfluidic flow control device
patent, October 2003


Particle packing of microdevice
patent-application, October 2005


Microfluidic system and methods of use
patent-application, September 2004


Method for etching vertical contact holes without substrate damage caused by directional etching
patent, August 1997


Composite Polymer Microfludic Control Device
patent-application, November 2007


Microfluidic system and methods of use
patent, May 2005


Method and apparatus for sorting particles
patent, January 2007


Method and apparatus for exposing cells to different concentrations of analytes or drugs
patent-application, January 2008


Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
patent-application, September 2005


    Works referencing / citing this record: