Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap
Abstract
Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1532114
- Patent Number(s):
- 8815177
- Application Number:
- 12/812,974
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2009-01-21
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS
Citation Formats
Perroud, Thomas D., and Patel, Kamlesh D. Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap. United States: N. p., 2014.
Web.
Perroud, Thomas D., & Patel, Kamlesh D. Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap. United States.
Perroud, Thomas D., and Patel, Kamlesh D. Tue .
"Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap". United States. https://www.osti.gov/servlets/purl/1532114.
@article{osti_1532114,
title = {Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap},
author = {Perroud, Thomas D. and Patel, Kamlesh D.},
abstractNote = {Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}
Works referenced in this record:
Fabrication of ultra-shallow channels for microfluidic devices and systems
patent, February 2007
- Moon, James E.; Young, Lincoln C.
- US Patent Document 7,171,975
Processing of particles
patent-application, November 2004
- Arnoldd, Don W.; Rakestraw, David J.; Paul, Phillip H.
- US Patent Application 10/849715; 20040235181
Microscale Electrochemical Cell And Methods Incorporating The Cell
patent-application, July 2008
- Arnold, Don W.; Jiang, Guifeng; Hebert, Nicole E.
- US Patent Application 11/627877; 20080182136
Apparatus and method for trapping bead based reagents within microfluidic analysis systems
patent, December 2007
- Harrison, D. Jed; Oleschuk, Richard D.; Shultz-Lockyear, Loranelle
- US Patent Document 7,312,611
Fabrication of ultra-shallow channels for microfluidic devices and systems
patent-application, September 2003
- Moon, James E.; Young, Lincoln C.
- US Patent Application 10/366087; 20030178075
Apparatus and method for trapping bead based reagents within microfluidic analysis systems
patent-application, November 2003
- Harrison, D. Jed; Jemere, Abebaw Belay
- US Patent Application 10/153854; 20030217923
Apparatus and methods for electrochemical processing of microfeature wafers
patent-application, July 2008
- McHugh, Paul R.; Wilson, Gregory J.; Woodruff, Daniel J.
- US Patent Application 11/699768; 20080179180
Wet chemical processing chambers for processing microfeature workpieces
patent-application, March 2005
- Hanson, Kyle M.; Dolechek, Kert L.; McHugh, Paul R.
- US Patent Application 10/859748; 20050050767
Particle packing of microdevice
patent, July 2006
- Yin, Hongfeng; Killeen, Kevin P.; Brennen, Reid A.
- US Patent Document 7,077,175
Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
patent-application, March 2006
- Wang, Mark M.; Tu, Eugene; Pestana, Luis M.
- US Patent Application 11/272593; 20060060767
Adjustable nanopore, nanotome, and nanotweezer
patent, March 2004
- Barth, Phillip W.; Roitman, Daniel B.; Myerson, Joel
- US Patent Document 6,706,203
Integrated system with modular microfluidic components
patent, July 2007
- Jovanovich, Stevan; Blaga, Iuliu Ioan; McIntosh, Roger
- US Patent Document 7,244,961
Particulate processing system
patent, May 2007
- Rakestraw, David J.; Arnold, Don W.; Paul, Phillip H.
- US Patent Document 7,220,592
Microfluidic devices comprising biochannels
patent-application, January 2005
- Blackburn, Gary
- US Patent Application 10/886408; 20050009101
Microfluidic flow control device
patent-application, December 2002
- Kornelsen, Kevin E.
- US Patent Application 09/888648; 20020197167
Microfluidic devices comprising biochannels
patent, April 2005
- Blackburn, Gary F.
- US Patent Document 6,875,619
Semiconductor device and method of fabricating the same
patent-application, January 2006
- Matsumoto, Takanori
- US Patent Application 11/180610; 20060014360
Microfluidic Device and Method of Using Same
patent-application, June 2008
- Li, Paul Chi Hang; Peng, Xing Yue
- US Patent Application 11/572134; 20080138848
Methods and compositions for selecting cells with increased potency
patent-application, October 2006
- Centanni, John M.; Allen-Hoffmann, Lynn
- US Patent Application 11/297916; 20060222635
Method and apparatus for separation of particles in a microfluidic device
patent, August 2006
- Pugia, Michael J.; Profitt, James A.; Schulman, Lloyd S.
- US Patent Document 7,094,354
Microfluidic system and methods of use
patent, October 2003
- Harrison, Daniel Jed; Andersson, Per X.; Li, Paul C. H.
- US Patent Document 6,632,619
Apparatus and method for trapping bead based reagents within microfluidic analysis systems
patent, August 2002
- Harrison, D. Jed; Oleschuk, Richard D.; Shultz-Lockyear, Loranelle
- US Patent Document 6,432,290
Method and apparatus for entry and storage of specimens into a microfluidic devic
patent-application, December 2004
- Pugia, Michael J.; Profit, James A.; Blankenstein, Gert
- US Patent Application 10/608671; 20040265172
Microfluidic devices
patent-application, October 2007
- Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan; Rank, David
- US Patent Application 11/229065; 20070248958
Heteroduplex tracking assay
patent-application, January 2008
- Philpott, Sean; Weiser, Barbara; Burger, Harold
- US Patent Application 11/654897; 20080020370
Polymorphic markers of the LSR gene
patent, October 2006
- Blumenfeld, Marta; Bougueleret, Lydie; Bihain, Bernard
- US Patent Document 7,125,667
Microfluidic Devices
patent-application, January 2008
- Jovanovich, Stevan B.; Blaga, Inliu I.; Rank, David
- US Patent Application 11/670866; 20080014576
Device and method for contacting picoliter volumes of fluid
patent-application, May 2007
- Irimia, Daniel; Toner, Mehmet
- US Patent Application 10/560661; 20070099289
Composite polymer microfluidic control device
patent, November 2007
- Rehm, Jason E.; Paul, Phillip H.; Cyr, Douglas R.
- US Patent Document 7,296,592
Microscale electrochemical cell and methods incorporating the cell
patent-application, July 2007
- Arnold, Don W.; Jiang, Guifeng; Herbert, Nicole F.
- US Patent Application 11/341221; 20070170056
Methods and Apparatus for the Manipulation of Particle Suspensions and Testing Thereof
patent-application, October 2007
- Ionescu-Zanetti, Cristian; Khine, Michelle; Schwartz, Michael
- US Patent Application 11/690831; 20070243523
Fluid control structures in microfluidic devices
patent-application, October 2004
- Mathies, Richard A.; Grover, William H.; Paegel, Brian
- US Patent Application 10/750533; 20040209354
Method for sorting particles
patent, December 2004
- Wang, Mark M.; Tu, Eugene; O'Connell, James P.
- US Patent Document 6,833,542
Chambers, systems, and methods for electrochemically processing microfeature workpieces
patent, April 2008
- Klocke, John L.; Hanson, Kyle M.
- US Patent Document 7,351,315
Microfluidic flow control device
patent, October 2003
- Kornelsen, Kevin E.
- US Patent Document 6,629,820
Particle packing of microdevice
patent-application, October 2005
- Yin, Hongfeng; Killeen, Kevin P.; Brennen, Reid A.
- US Patent Application 10/821543; 20050224134
Microfluidic system and methods of use
patent-application, September 2004
- Harrison, Daniel Jed; Li, Paul C. H.; Szarka, Roderick
- US Patent Application 10/637689; 20040178071
Method for etching vertical contact holes without substrate damage caused by directional etching
patent, August 1997
- Cronin, John; Potter, Michael D.; Starkey, Jr., Gorden Seth
- US Patent Document 5,654,238
Composite Polymer Microfludic Control Device
patent-application, November 2007
- Rehm, Jason E.; Paul, Phillip H.; Cyr, Douglas R.
- US Patent Application 10/572181; 20070272309
Microfluidic system and methods of use
patent, May 2005
- Harrison, Daniel Jed; Andersson, Per X.; Li, Paul C. H.
- US Patent Document 6,900,021
Method and apparatus for sorting particles
patent, January 2007
- Bhm, Sebastian; Gilbert, John R.; Deshpande, Manish
- US Patent Document 7,157,274
Method and apparatus for exposing cells to different concentrations of analytes or drugs
patent-application, January 2008
- Yang, Mengsu; Li, Cheuk-Wing
- US Patent Application 11/489849; 20080020368
Efficient compound distribution in microfluidic devices
patent, November 2004
- Boone, Travis D.
- US Patent Document 6,824,663
Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
patent-application, September 2005
- Butler, William Frank; Chachisvilis, Mirianas; Dees, Robert
- US Patent Application 10/928650; 20050207940
Works referencing / citing this record:
Microfluidic contaminant trap for trapping contaminants in gas chromatography
patent, May 2017
- Walsh, George P.; Veeneman, Rebecca A.
- US Patent Document 9,664,598
Method for measuring bacterial growth and antibiotic resistance using suspended microchannel resonators
patent, February 2017
- Babcock, Kenneth L.; Manalis, Scott R.
- US Patent Document 9,581,569