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Title: Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap

Abstract

Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.

Inventors:
;
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1532114
Patent Number(s):
8815177
Application Number:
12/812,974
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009-01-21
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS

Citation Formats

Perroud, Thomas D., and Patel, Kamlesh D. Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap. United States: N. p., 2014. Web.
Perroud, Thomas D., & Patel, Kamlesh D. Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap. United States.
Perroud, Thomas D., and Patel, Kamlesh D. Tue . "Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap". United States. https://www.osti.gov/servlets/purl/1532114.
@article{osti_1532114,
title = {Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap},
author = {Perroud, Thomas D. and Patel, Kamlesh D.},
abstractNote = {Disclosed herein are methods of immobilizing a particle which comprise focusing the flow of a sample fluid containing the particle into a virtual channel which flows towards an unoccupied hydrodynamic trap in a microfluidic channel such that the particle flows into the hydrodynamic trap and becomes immobilized therein. Also disclosed are microfluidic devices which comprise at least one microchannel having at least one hydrodynamic trap, at least one focusing fluid inlet, said focusing fluid inlet is upstream of the hydrodynamic trap such that a focusing fluid introduced therein results in a virtual channel of a sample fluid when present which preferentially flows toward the hydrodynamic trap.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}

Patent:

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