Compounds for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
Abstract
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1531922
- Patent Number(s):
- 9393330
- Application Number:
- 14/067,064
- Assignee:
- STC.UNM (Albuquerque, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013-10-30
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Miao, Yubin, and Guo, Haixun. Compounds for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same. United States: N. p., 2016.
Web.
Miao, Yubin, & Guo, Haixun. Compounds for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same. United States.
Miao, Yubin, and Guo, Haixun. Tue .
"Compounds for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same". United States. https://www.osti.gov/servlets/purl/1531922.
@article{osti_1531922,
title = {Compounds for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same},
author = {Miao, Yubin and Guo, Haixun},
abstractNote = {The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 19 00:00:00 EDT 2016},
month = {Tue Jul 19 00:00:00 EDT 2016}
}
Works referenced in this record:
Cyclic analogs of alpha-MSH fragments
patent, October 1997
- Hruby, Victor J.; Hadley, Mac E.; Al-Obeidi, Fahad
- US Patent Document 5,674,839
Method of Inducing Melanogenesis in Humans With Mc1R Variant Alleles
patent-application, January 2008
- Humphrey, Stuart Michael
- US Patent Application 10/595971; 20080004213
Compounds and methods for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
patent, December 2013
- Miao, Yubin; Guo, Haixun
- US Patent Document 8,603,435