Methods for determining absorbed dose information
Abstract
The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.
- Inventors:
- Issue Date:
- Research Org.:
- Johns Hopkins Univ., Baltimore, MD (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531919
- Patent Number(s):
- 9387344
- Application Number:
- 12/514,853
- Assignee:
- The Johns Hopkins University (Baltimore, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- FG02-05ER63967
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2007-11-21
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Methods for determining absorbed dose information. United States: N. p., 2016.
Web.
Sgouros, George, Song, Hong, Prideaux, Andrew, & Hobbs, Robert. Methods for determining absorbed dose information. United States.
Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Tue .
"Methods for determining absorbed dose information". United States. https://www.osti.gov/servlets/purl/1531919.
@article{osti_1531919,
title = {Methods for determining absorbed dose information},
author = {Sgouros, George and Song, Hong and Prideaux, Andrew and Hobbs, Robert},
abstractNote = {The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}
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