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Title: Methods for determining absorbed dose information

Abstract

The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.

Inventors:
; ; ;
Issue Date:
Research Org.:
Johns Hopkins Univ., Baltimore, MD (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531919
Patent Number(s):
9,387,344
Application Number:
12/514,853
Assignee:
The Johns Hopkins University (Baltimore, MD)
DOE Contract Number:  
FG02-05ER63967
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007-11-21
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Methods for determining absorbed dose information. United States: N. p., 2016. Web.
Sgouros, George, Song, Hong, Prideaux, Andrew, & Hobbs, Robert. Methods for determining absorbed dose information. United States.
Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Tue . "Methods for determining absorbed dose information". United States. https://www.osti.gov/servlets/purl/1531919.
@article{osti_1531919,
title = {Methods for determining absorbed dose information},
author = {Sgouros, George and Song, Hong and Prideaux, Andrew and Hobbs, Robert},
abstractNote = {The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}

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Works referenced in this record:

Method for preparing a radiation therapy plan
patent, May 2003


Method of establishing the optimal radiation dose
patent, June 2001


Patient-specific dosimetry
patent-application, December 2005


Reconstruction of local patient doses in computed tomography
patent, August 2010


Radioimmunotherapy of lymphoma using anti-CD20 antibodies
patent, July 2000


Patient-specific dosimetry
patent, February 2010


View to view image correction for object motion with truncated data
patent, August 1994


System, method, computer-readable medium, and use for planning combined therapy
patent, March 2014


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