Methods for determining absorbed dose information

Title: Methods for determining absorbed dose information

Abstract

The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.

Inventors:: Sgouros, George; Song, Hong; Prideaux, Andrew; Hobbs, Robert

Issue Date:: 2016-07-12

Research Org.:: Johns Hopkins Univ., Baltimore, MD (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531919

Patent Number(s):: 9,387,344

Application Number:: 12/514,853

Assignee:: The Johns Hopkins University (Baltimore, MD)

DOE Contract Number:: FG02-05ER63967

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007-11-21

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats


                    Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Methods for determining absorbed dose information.  United States: N. p., 2016. 
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                    Sgouros, George, Song, Hong, Prideaux, Andrew, & Hobbs, Robert. Methods for determining absorbed dose information.  United States.

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                    Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Tue .  
        "Methods for determining absorbed dose information".  United States.  https://www.osti.gov/servlets/purl/1531919.

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@article{osti_1531919,

  title        = {Methods for determining absorbed dose information},

  author       = {Sgouros, George and Song, Hong and Prideaux, Andrew and Hobbs, Robert},

  abstractNote = {The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {7}

}

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Gattiker, Anne; Nassif, Sani R.; Osiecki, Tom
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Title: Methods for determining absorbed dose information

Abstract

Citation Formats

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