Methods for determining absorbed dose information
Abstract
The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.
- Inventors:
- Issue Date:
- Research Org.:
- Johns Hopkins Univ., Baltimore, MD (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531919
- Patent Number(s):
- 9387344
- Application Number:
- 12/514,853
- Assignee:
- The Johns Hopkins University (Baltimore, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- FG02-05ER63967
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2007-11-21
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Methods for determining absorbed dose information. United States: N. p., 2016.
Web.
Sgouros, George, Song, Hong, Prideaux, Andrew, & Hobbs, Robert. Methods for determining absorbed dose information. United States.
Sgouros, George, Song, Hong, Prideaux, Andrew, and Hobbs, Robert. Tue .
"Methods for determining absorbed dose information". United States. https://www.osti.gov/servlets/purl/1531919.
@article{osti_1531919,
title = {Methods for determining absorbed dose information},
author = {Sgouros, George and Song, Hong and Prideaux, Andrew and Hobbs, Robert},
abstractNote = {The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}
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Works referenced in this record:
Orthovoltage Radiosurgery
patent-application, October 2008
- Gertner, Michael; Hansen, Steven D.
- US Patent Application 12/100398; 20080247510
Automatic therapy advisor
patent-application, February 2006
- Freeman, Gary A.; Brewer, James E.
- US Patent Application 11/136327; 20060025824
Method for preparing a radiation therapy plan
patent, May 2003
- Shepard, David M.; Hoban, Peter; Mackie, Thomas R.
- US Patent Document 6,560,311
Method of establishing the optimal radiation dose
patent, June 2001
- Wahl, Richard L.; Zasadny, Kenneth R.
- US Patent Document 6,251,362
Combination valve for fuel system
patent-application, February 2005
- Roth, Robert A.; McGrath, Dennis P.
- US Patent Application 10/634085; 20050028869
Use of Planning Atlas in Radiation Therapy
patent-application, September 2010
- Nord, Janne; Zankowski, Corey Edmund
- US Patent Application 12/402393; 20100232572
Patient-specific dosimetry
patent-application, December 2005
- Kroll, Stewart M.; Siegal, Jeffrey A.; Wahl, Richard L.
- US Patent Application 11/200688; 20050288869
Dose Calculation Method for Multiple Fields
patent-application, April 2011
- Siljamaki, Sami Pekka; Nord, Janne Ilmari; Korhonen, Laura Kristina
- US Patent Application 12/582332; 20110091014
Systems and methods for global optimization of treatment planning for external beam radiation therapy
patent, May 2006
- Lee, Eva K.
- US Patent Document 7,046,762
Reconstruction of local patient doses in computed tomography
patent, August 2010
- Botterweck, Henrik; Spies, Lothar
- US Patent Document 7,787,669
Computer implemented patient medication review system and process for the managed care, health care and/or pharmacy industry
patent, February 2004
- Teagarden, J. Russel; Clotz, Michael; Angaran, David
- US Patent Document 6,694,298
Treatment Planning System and Method for Radiotherapy
patent-application, June 2009
- Nord, Janne Ilmari; Rusanen, Marko Tapio
- US Patent Application 11/954638; 20090154644
Inverse planning for intensity-modulated radiotherapy
patent-application, November 2003
- McNutt, Todd R.; Tipton, R. Keith; Ward, R. Terry
- US Patent Application 10/154135; 20030219098
Radioimmunotherapy of lymphoma using anti-CD20 antibodies
patent, July 2000
- Kaminski, Mark S.; Butchko, Gregory M.; Glenn, Stephan D.
- US Patent Document 6,090,365
System, Method, Computer-Readable Medium, and Use for Planning Combined Therapy
patent-application, April 2010
- Georgi, Jens-Christoph; Schweizer, Bernd
- US Patent Application 12/517717; 20100081857
Radioactive arsenic-containing compounds and their uses in the treatment of tumors
patent-application, October 2004
- Huang, Chun-Ying; Wu, Ming-Shiuan; Lee, Te-Wei
- US Patent Application 10/792191; 20040213737
Patient-specific dosimetry
patent, February 2010
- Kroll, Stewart M.; Siegal, Jeffry A.; Wahl, Richard L.
- US Patent Document 7,668,662
Gamma camera and CT system
patent-application, March 2006
- Balan, Adi; Shrem, Yigal; Lonn, Albert
- US Patent Application 11/217644; 20060050839
Treatment Plan Optimization Method for Radiation Therapy
patent-application, December 2009
- Nord, Janne Ilmari; Peltola, Jarkko Yrjana
- US Patent Application 12/142181; 20090316858
Methods and computer readable medium for improved radiotherapy dosimetry planning
patent-application, April 2002
- Wessol, Daniel E.; Frandson, Michael W.; Wheeler, Floyd J.
- US Patent Application 09/814299; 20020046010
View to view image correction for object motion with truncated data
patent, August 1994
- Nowak, Michael P.; Nowak, David J.
- US Patent Document 5,337,231
Methods and systems for guiding selection of chemotherapeutic agents
patent-application, March 2006
- Bruckner, Howard W.
- US Patent Application 10/941089; 20060058966
Method for treatment of tumors using combination therapy
patent-application, July 2004
- Thomas, Elaine K.; Lyman, Stewart D.; Lynch, David H.
- US Patent Application 10/381160; 20040131587
System, method, computer-readable medium, and use for planning combined therapy
patent, March 2014
- Georgi, Jens-Christoph; Schweizer, Bernd
- US Patent Document 8,663,083
Works referencing / citing this record:
Radiation therapy treatment planning using regression
patent, June 2018
- Gattiker, Anne; Nassif, Sani R.; Osiecki, Tom
- US Patent Document 9,987,502