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Title: Method and apparatus for extraction of strontium from urine

Abstract

The present invention provides an apparatus and rapid methods for extracting strontium ions from urine to provide a concentrated and purified strontium-90 extract suitable for scintillation measurements. The methods remove organic compounds, pigments, and alkali metal ions that can interfere with quantitative determination of strontium-90 in urine. A method of the invention comprises acidifying urine and removing organic pigments therefrom, loading a known quantity of so-treated urine onto a diphosphonic acid-based ion-exchange resin; flowing aqueous methanesulfonic acid through the diphosphonic acid-based ion-exchange resin to elute alkali metal ions therefrom; eluting strontium ions off of the diphosphonic acid-based resin and on to a strontium extraction chromatographic resin with a concentrated aqueous nitric acid solution; subsequently flowing water or a dilute acid stripping solution through the strontium extraction resin to strip the strontium from the strontium extraction resin; and collecting the strontium-containing stripping solution eluting from the strontium extraction resin.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531865
Patent Number(s):
8507284
Application Number:
13/182,873
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011-07-14
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Kaminski, Michael D., Mertz, Carol J., Shkrob, Ilya A., Dietz, Mark L., and Hawkins, Cory A. Method and apparatus for extraction of strontium from urine. United States: N. p., 2013. Web.
Kaminski, Michael D., Mertz, Carol J., Shkrob, Ilya A., Dietz, Mark L., & Hawkins, Cory A. Method and apparatus for extraction of strontium from urine. United States.
Kaminski, Michael D., Mertz, Carol J., Shkrob, Ilya A., Dietz, Mark L., and Hawkins, Cory A. Tue . "Method and apparatus for extraction of strontium from urine". United States. https://www.osti.gov/servlets/purl/1531865.
@article{osti_1531865,
title = {Method and apparatus for extraction of strontium from urine},
author = {Kaminski, Michael D. and Mertz, Carol J. and Shkrob, Ilya A. and Dietz, Mark L. and Hawkins, Cory A.},
abstractNote = {The present invention provides an apparatus and rapid methods for extracting strontium ions from urine to provide a concentrated and purified strontium-90 extract suitable for scintillation measurements. The methods remove organic compounds, pigments, and alkali metal ions that can interfere with quantitative determination of strontium-90 in urine. A method of the invention comprises acidifying urine and removing organic pigments therefrom, loading a known quantity of so-treated urine onto a diphosphonic acid-based ion-exchange resin; flowing aqueous methanesulfonic acid through the diphosphonic acid-based ion-exchange resin to elute alkali metal ions therefrom; eluting strontium ions off of the diphosphonic acid-based resin and on to a strontium extraction chromatographic resin with a concentrated aqueous nitric acid solution; subsequently flowing water or a dilute acid stripping solution through the strontium extraction resin to strip the strontium from the strontium extraction resin; and collecting the strontium-containing stripping solution eluting from the strontium extraction resin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {8}
}

Works referenced in this record:

Alkaline earth cation extraction from acid solution
patent, January 2003


Validation of deuterium-labeled fatty acids for the measurement of dietary fat oxidation during physical activity
journal, December 2004


Phosphonic acid based exchange resins
patent, September 1995


Process for the recovery of strontium from acid solutions
patent, March 1992


Method for actinides and Sr-90 determination in urine samples
journal, September 1996


Phosphonic acid based ion exchange resins
patent, July 1996


New method for90Sr determination in liquid samples
journal, April 1995


Determination of strontium-90 in urine by extraction without ashing
journal, March 1984


Doubly labeled water analysis using cavity ring-down spectroscopy: Doubly labeled water analysis using CRDS
journal, December 2010


Rapid analysis of emergency urine and water samples
journal, October 2007


A Novel Strontium-Selective Extraction Chromatographic Resin*
journal, April 1992


Phosphonic acid based ion exchange resins
patent, January 1994


Liquid chromatographic extraction medium
patent, September 1994


Determination of strontium-90 in water and urine samples using ion chromatography
journal, January 1994