Neurotransmitter sensors and methods of using the same
Abstract
Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.
- Inventors:
- Issue Date:
- Research Org.:
- Carnegie Inst. of Washington, Washington, DC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531775
- Patent Number(s):
- 8354250
- Application Number:
- 12/823,796
- Assignee:
- Carnegie Institution of Washington (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FG02-04ER15542
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010-06-25
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Okumoto, Sakiko, Looger, Loren L., and Frommer, Wolf B. Neurotransmitter sensors and methods of using the same. United States: N. p., 2013.
Web.
Okumoto, Sakiko, Looger, Loren L., & Frommer, Wolf B. Neurotransmitter sensors and methods of using the same. United States.
Okumoto, Sakiko, Looger, Loren L., and Frommer, Wolf B. Tue .
"Neurotransmitter sensors and methods of using the same". United States. https://www.osti.gov/servlets/purl/1531775.
@article{osti_1531775,
title = {Neurotransmitter sensors and methods of using the same},
author = {Okumoto, Sakiko and Looger, Loren L. and Frommer, Wolf B.},
abstractNote = {Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {1}
}
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