Micro fluidic system for single molecule imaging

Title: Micro fluidic system for single molecule imaging

Abstract

Laminar flow of a carrier liquid and polymeric molecules through micro-channels is used to straighten the polymeric molecules and attach the straightened molecules to a wall of the micro-channel for subsequent treatment and analysis. Micro-channels can be manufactured using an elastic molding material. One micro-channel embodiment provides fluid flow using a standard laboratory centrifuge.

Inventors:: Schwartz, David C.; Dimalanta, Eileen T.; de Pablo, Juan J.

Issue Date:: 2012-03-27

Research Org.:: Wisconsin Alumni Research Foundation, Madison, WI (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531728

Patent Number(s):: 8,142,708

Application Number:: 10/713,898

Assignee:: Wisconsin Alumni Research Foundation (Madison, WI)

DOE Contract Number:: FG02-99ER62830; NIH HG00225

Resource Type:: Patent

Resource Relation:: Patent File Date: 2002-10-18

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Schwartz, David C., Dimalanta, Eileen T., and de Pablo, Juan J. Micro fluidic system for single molecule imaging.  United States: N. p., 2012. 
        Web.

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                    Schwartz, David C., Dimalanta, Eileen T., & de Pablo, Juan J. Micro fluidic system for single molecule imaging.  United States.

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                    Schwartz, David C., Dimalanta, Eileen T., and de Pablo, Juan J. Tue .  
        "Micro fluidic system for single molecule imaging".  United States.  https://www.osti.gov/servlets/purl/1531728.

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@article{osti_1531728,

  title        = {Micro fluidic system for single molecule imaging},

  author       = {Schwartz, David C. and Dimalanta, Eileen T. and de Pablo, Juan J.},

  abstractNote = {Laminar flow of a carrier liquid and polymeric molecules through micro-channels is used to straighten the polymeric molecules and attach the straightened molecules to a wall of the micro-channel for subsequent treatment and analysis. Micro-channels can be manufactured using an elastic molding material. One micro-channel embodiment provides fluid flow using a standard laboratory centrifuge.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2012},

  month        = {3}

}

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Nanochannel device with three dimensional gradient by single step etching for molecular detection
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US Patent Document 9,322,061
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=9322061

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Similar Records

Title: Micro fluidic system for single molecule imaging

Abstract

Citation Formats

Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action patent, July 2004

Field-inversion gel electrophoresis patent, April 1988

Image processing and analysis of individual nucleic acid molecules patent, February 1998

Method for optically manipulating polymer filaments patent, January 1992

Methods and compositions for the manipulation and characterization of individual nucleic acid molecules patent, May 2006

Gel inserts useful in electrophoresis patent, September 1987

Method for separating nucleic acids and nucleic acid probes patent, October 1991

Unitary microcapiliary and waveguide structure and method of fabrication patent, August 2002

Image processing and analysis of individual nucleic acid molecules patent, January 2003

Acrylic microchannels and their use in electrophoretic applications patent, April 2000

Non-isotopic in-situ hybridization method for detection of nucleic acids patent, November 1999

Electrophoresis using alternating transverse electric fields patent, September 1984

Image processing and analysis of individual nucleic acid molecules patent, August 2003

Process for aligning macromolecules by passage of a meniscus and applications patent, July 2001

Methods and apparatuses for stretching polymers patent, February 2004

Method for imaging informational biological molecules on a semiconductor substrate patent, May 1994

DNA measuring method patent, October 1994

Nanoelectrode arrays patent, September 2000

Apparatus and method of analyzing nucleic acid molecules patent, September 1989

Polynucleotide reagents containing selectable cleavage sites patent, January 1995

Detection of particular nucleotide sequences patent, August 1988

Nanochannel device with three dimensional gradient by single step etching for molecular detection patent, April 2016

Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
patent, July 2004

Field-inversion gel electrophoresis
patent, April 1988

Image processing and analysis of individual nucleic acid molecules
patent, February 1998

Method for optically manipulating polymer filaments
patent, January 1992

Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
patent, May 2006

Gel inserts useful in electrophoresis
patent, September 1987

Method for separating nucleic acids and nucleic acid probes
patent, October 1991

Unitary microcapiliary and waveguide structure and method of fabrication
patent, August 2002

Image processing and analysis of individual nucleic acid molecules
patent, January 2003

Acrylic microchannels and their use in electrophoretic applications
patent, April 2000

Non-isotopic in-situ hybridization method for detection of nucleic acids
patent, November 1999

Electrophoresis using alternating transverse electric fields
patent, September 1984

Image processing and analysis of individual nucleic acid molecules
patent, August 2003

Process for aligning macromolecules by passage of a meniscus and applications
patent, July 2001

Methods and apparatuses for stretching polymers
patent, February 2004

Method for imaging informational biological molecules on a semiconductor substrate
patent, May 1994

DNA measuring method
patent, October 1994

Nanoelectrode arrays
patent, September 2000

Apparatus and method of analyzing nucleic acid molecules
patent, September 1989

Polynucleotide reagents containing selectable cleavage sites
patent, January 1995

Detection of particular nucleotide sequences
patent, August 1988

Nanochannel device with three dimensional gradient by single step etching for molecular detection
patent, April 2016