High temperature ion channels and pores
Abstract
The present invention includes an apparatus, system and method for stochastic sensing of an analyte to a protein pore. The protein pore may be an engineer protein pore, such as an ion channel at temperatures above 55° C. and even as high as near 100° C. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable electrical current signal. Possible signals include change in electrical current. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may also be detected.
- Inventors:
- Issue Date:
- Research Org.:
- Texas A&M Univ., College Station, TX (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531668
- Patent Number(s):
- 7867716
- Application Number:
- 11/314,174
- Assignee:
- The Texas A&M University System (College Station, TX)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2005-12-21
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kang, Xiaofeng, Gu, Li Qun, Cheley, Stephen, and Bayley, Hagan P. High temperature ion channels and pores. United States: N. p., 2011.
Web.
Kang, Xiaofeng, Gu, Li Qun, Cheley, Stephen, & Bayley, Hagan P. High temperature ion channels and pores. United States.
Kang, Xiaofeng, Gu, Li Qun, Cheley, Stephen, and Bayley, Hagan P. Tue .
"High temperature ion channels and pores". United States. https://www.osti.gov/servlets/purl/1531668.
@article{osti_1531668,
title = {High temperature ion channels and pores},
author = {Kang, Xiaofeng and Gu, Li Qun and Cheley, Stephen and Bayley, Hagan P.},
abstractNote = {The present invention includes an apparatus, system and method for stochastic sensing of an analyte to a protein pore. The protein pore may be an engineer protein pore, such as an ion channel at temperatures above 55° C. and even as high as near 100° C. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable electrical current signal. Possible signals include change in electrical current. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may also be detected.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {1}
}
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Works referencing / citing this record:
Electrical double layer capacitive devices and methods of using same for sequencing polymers and detecting analytes
patent, October 2014
- Zhang, Guigen
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Microfabrication methods for the optimal patterning of substrates
patent, June 2017
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Stochastic sensing through covalent interactions
patent, March 2013
- Bayley, Hagan; Shin, Seong-Ho; Luchian, Tudor
- US Patent Document 8,404,449