Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Chung, Seok-Hwan; Hoffmann, Axel F.; Bader, Samuel D.

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Title: Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Abstract

A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

Inventors:: Chung, Seok-Hwan; Hoffmann, Axel F.; Bader, Samuel D.

Issue Date:: 2009-12-29

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531619

Patent Number(s):: 7639359

Application Number:: 11/875,475

Assignee:: UChicago Argonne, LLC (Chicago, IL)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2021/1727 - {Magnetomodulation}
G01N21/1717 - {with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/1207 - {Testing individual magnetic storage devices, e.g. records carriers or digital storage elements
G01R33/1269 - {of molecules labeled with magnetic beads

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DOE Contract Number:: AC02-06CH11357; W-31-109-ENG-38

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007-10-19

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats


                    Chung, Seok-Hwan, Hoffmann, Axel F., and Bader, Samuel D. Magneto-optic biosensor using bio-functionalized magnetized nanoparticles.  United States: N. p., 2009. 
        Web.

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                    Chung, Seok-Hwan, Hoffmann, Axel F., & Bader, Samuel D. Magneto-optic biosensor using bio-functionalized magnetized nanoparticles.  United States.

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                    Chung, Seok-Hwan, Hoffmann, Axel F., and Bader, Samuel D. Tue .  
        "Magneto-optic biosensor using bio-functionalized magnetized nanoparticles".  United States.  https://www.osti.gov/servlets/purl/1531619.

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@article{osti_1531619,

  title        = {Magneto-optic biosensor using bio-functionalized magnetized nanoparticles},

  author       = {Chung, Seok-Hwan and Hoffmann, Axel F. and Bader, Samuel D.},

  abstractNote = {A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2009},

  month        = {12}

}

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Works referenced in this record:

Optical coherence tomographic detection of cells and compositions
patent-application, February 2007

Feldman, Marc D.; Milner, Thomas E.; Oh, Jung-Hwan
US Patent Application 11/441824; 20070038121
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070038121

Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles
journal, February 2008

Chung, Seok-Hwan; Grimsditch, Marcos; Hoffmann, Axel
Journal of Magnetism and Magnetic Materials, Vol. 320, Issue 3-4
https://doi.org/10.1016/j.jmmm.2007.05.016

Nanoparticles biosensor
patent, July 1999

Ewart, Thomas; Bogle, Gavin T.
US Patent Document 5,922,537
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5922537

Magnetic Porous Particles and Method of Making
patent-application, December 2008

Sailor, Michael J.; Li, Yang Yang; Trujillo, Nathan
US Patent Application 11/632914; 20080296255
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080296255

Method and arrangement for detecting changes of a magnetic response in magnetic particles
patent, November 2004

Minchole, Ana; Astalan, Andrea P.; Johansson, Christer
US Patent Document 6,825,655
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Magnetic Separation and Apparatus and Methods
patent-application, January 2004

Terstappen, Leon W. M. M.; Dolan, Gerald
US Patent Application 10/602979; 20040004043
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040004043

Works referencing / citing this record:

Robust determination of the anisotropic polarizability of nanoparticles using coherent confocal microscopy
patent, October 2011

Davis, Brynmor J.; Carney, Paul Scott
US Patent Document 8,045,161
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8045161

Diagnostic devices and methods
patent, October 2017

Grimberg, Brian T.; Deissler, Robert; Condit, William
US Patent Document 9,778,245
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9778245

Biosensor based on measurements of the clustering dynamics of magnetic particles
patent, October 2017

Donolato, Marco; Hansen, Mikkel F.; Vavassori, Paolo
US Patent Document 9,784,736
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9784736

Biosensor based on the measurements of clustering dynamics of magnetic particles using a double pass setup
patent, October 2017

Donolato, Marco; Bosco, Filippo Giacomo; Hansen, Mikkel F.
US Patent Document 9,784,735
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9784735

Magneto-optical bio-detection devices having high sensitivity
patent, December 2018

Wu, Ping-Chieh
US Patent Document 10,161,856
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10161856

Engineered particles with polarization contrast and alignment control for enhanced imaging
patent, March 2019

Homyk, Andrew; Acosta, Victor Marcel; Bajaj, Vikram Singh
US Patent Document 10,228,366
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10228366

Target substance detection kit and target substance detection method
patent, December 2011

Ikeda, Takashi
US Patent Document 8,076,161
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8076161

Engineered particles with polarization contrast and alignment control for enhanced imaging
patent, May 2017

Homyk, Andrew; Acosta, Victor Marcel; Bajaj, Vikram Singh
US Patent Document 9,642,923
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9642923

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Similar Records

Title: Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Abstract

Citation Formats

Optical coherence tomographic detection of cells and compositions patent-application, February 2007

Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles journal, February 2008

Nanoparticles biosensor patent, July 1999

Magnetic Porous Particles and Method of Making patent-application, December 2008

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Magnetic Separation and Apparatus and Methods patent-application, January 2004

Robust determination of the anisotropic polarizability of nanoparticles using coherent confocal microscopy patent, October 2011

Diagnostic devices and methods patent, October 2017

Biosensor based on measurements of the clustering dynamics of magnetic particles patent, October 2017

Biosensor based on the measurements of clustering dynamics of magnetic particles using a double pass setup patent, October 2017

Magneto-optical bio-detection devices having high sensitivity patent, December 2018

Engineered particles with polarization contrast and alignment control for enhanced imaging patent, March 2019

Target substance detection kit and target substance detection method patent, December 2011

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patent-application, February 2007

Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles
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patent-application, December 2008

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