Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Chung, Seok-Hwan; Hoffmann, Axel F.; Bader, Samuel D.

Title: Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Abstract

A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

Inventors:: Chung, Seok-Hwan; Hoffmann, Axel F.; Bader, Samuel D.

Issue Date:: 2009-12-29

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531619

Patent Number(s):: 7639359

Application Number:: 11/875,475

Assignee:: UChicago Argonne, LLC (Chicago, IL)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2021/1727 - {Magnetomodulation}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/1207 - {Testing individual magnetic storage devices, e.g. records carriers or digital storage elements

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/1717 - {with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance}

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/1269 - {of molecules labeled with magnetic beads

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DOE Contract Number:: AC02-06CH11357; W-31-109-ENG-38

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007-10-19

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats


                    Chung, Seok-Hwan, Hoffmann, Axel F., and Bader, Samuel D. Magneto-optic biosensor using bio-functionalized magnetized nanoparticles.  United States: N. p., 2009. 
        Web.

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                    Chung, Seok-Hwan, Hoffmann, Axel F., & Bader, Samuel D. Magneto-optic biosensor using bio-functionalized magnetized nanoparticles.  United States.

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                    Chung, Seok-Hwan, Hoffmann, Axel F., and Bader, Samuel D. Tue .  
        "Magneto-optic biosensor using bio-functionalized magnetized nanoparticles".  United States.  https://www.osti.gov/servlets/purl/1531619.

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@article{osti_1531619,

  title        = {Magneto-optic biosensor using bio-functionalized magnetized nanoparticles},

  author       = {Chung, Seok-Hwan and Hoffmann, Axel F. and Bader, Samuel D.},

  abstractNote = {A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2009},

  month        = {12}

}

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Works referenced in this record:

Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles
journal, February 2008

Chung, Seok-Hwan; Grimsditch, Marcos; Hoffmann, Axel
Journal of Magnetism and Magnetic Materials, Vol. 320, Issue 3-4
https://doi.org/10.1016/j.jmmm.2007.05.016

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Title: Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Abstract

Citation Formats

Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles journal, February 2008

Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles
journal, February 2008