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Title: Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Abstract

A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

Inventors:
; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531619
Patent Number(s):
7,639,359
Application Number:
11/875,475
Assignee:
UChicago Argonne, LLC (Chicago, IL)
DOE Contract Number:  
AC02-06CH11357; W-31-109-ENG-38
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007-10-19
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Chung, Seok-Hwan, Hoffmann, Axel F., and Bader, Samuel D. Magneto-optic biosensor using bio-functionalized magnetized nanoparticles. United States: N. p., 2009. Web.
Chung, Seok-Hwan, Hoffmann, Axel F., & Bader, Samuel D. Magneto-optic biosensor using bio-functionalized magnetized nanoparticles. United States.
Chung, Seok-Hwan, Hoffmann, Axel F., and Bader, Samuel D. Tue . "Magneto-optic biosensor using bio-functionalized magnetized nanoparticles". United States. https://www.osti.gov/servlets/purl/1531619.
@article{osti_1531619,
title = {Magneto-optic biosensor using bio-functionalized magnetized nanoparticles},
author = {Chung, Seok-Hwan and Hoffmann, Axel F. and Bader, Samuel D.},
abstractNote = {A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {12}
}

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Works referenced in this record:

Nanoparticles biosensor
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Method and arrangement for detecting changes of a magnetic response in magnetic particles
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