Methods of obtaining active antisense compounds
Abstract
Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Isis Pharmaceuticals, Inc., Carlsbad, CA (United States); Univ. of Utah, Salt Lake City, UT (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531599
- Patent Number(s):
- 7592440
- Application Number:
- 10/686,317
- Assignee:
- Isis Pharmaceuticals, Inc. (Carlsbad, CA); University of Utah Research Foundation (Salt Lake City, UT)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG03-99ER62732
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2003-10-15
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Freier, Susan M., Matveeva, Olga, Tsodikov, Alexander, Giddings, Michael C., and Wyatt, Jacqueline R. Methods of obtaining active antisense compounds. United States: N. p., 2009.
Web.
Freier, Susan M., Matveeva, Olga, Tsodikov, Alexander, Giddings, Michael C., & Wyatt, Jacqueline R. Methods of obtaining active antisense compounds. United States.
Freier, Susan M., Matveeva, Olga, Tsodikov, Alexander, Giddings, Michael C., and Wyatt, Jacqueline R. Tue .
"Methods of obtaining active antisense compounds". United States. https://www.osti.gov/servlets/purl/1531599.
@article{osti_1531599,
title = {Methods of obtaining active antisense compounds},
author = {Freier, Susan M. and Matveeva, Olga and Tsodikov, Alexander and Giddings, Michael C. and Wyatt, Jacqueline R.},
abstractNote = {Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 22 00:00:00 EDT 2009},
month = {Tue Sep 22 00:00:00 EDT 2009}
}
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