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Title: Methods of obtaining active antisense compounds

Abstract

Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Isis Pharmaceuticals, Inc., Carlsbad, CA (United States); Univ. of Utah, Salt Lake City, UT (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531599
Patent Number(s):
7,592,440
Application Number:
10/686,317
Assignee:
Isis Pharmaceuticals, Inc. (Carlsbad, CA); University of Utah Research Foundation (Salt Lake City, UT)
DOE Contract Number:  
FG03-99ER62732
Resource Type:
Patent
Resource Relation:
Patent File Date: 2003-10-15
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Freier, Susan M., Matveeva, Olga, Tsodikov, Alexander, Giddings, Michael C., and Wyatt, Jacqueline R. Methods of obtaining active antisense compounds. United States: N. p., 2009. Web.
Freier, Susan M., Matveeva, Olga, Tsodikov, Alexander, Giddings, Michael C., & Wyatt, Jacqueline R. Methods of obtaining active antisense compounds. United States.
Freier, Susan M., Matveeva, Olga, Tsodikov, Alexander, Giddings, Michael C., and Wyatt, Jacqueline R. Tue . "Methods of obtaining active antisense compounds". United States. https://www.osti.gov/servlets/purl/1531599.
@article{osti_1531599,
title = {Methods of obtaining active antisense compounds},
author = {Freier, Susan M. and Matveeva, Olga and Tsodikov, Alexander and Giddings, Michael C. and Wyatt, Jacqueline R.},
abstractNote = {Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {9}
}

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Works referenced in this record:

Inhibitors of human immunodeficiency virus
patent, June 1996


Antisense oligonucleotides to human serine/threonine protein phosphatase genes
patent, September 1999


Antisense oligonucleotides against human protein kinase C
patent, March 1999


Oligonucleotides having a conserved G4 core sequence
patent, September 1999


Phosphorothioate oligonucleotides that bind to the V3-loop and uses thereof
patent, May 1998


RNase L activators and antisense oligonucleotides effective to treat RSV infections
patent, April 2001


Human VEGF-specific oligonucleotides
patent, August 1997


Antisense oligonucleotide modulation of multidrug resistance-associated protein
patent, September 1998