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Title: Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom

Abstract

The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.

Inventors:
; ; ;
Issue Date:
Research Org.:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531589
Patent Number(s):
7534761
Application Number:
10/645,304
Assignee:
Northwestern University (Evanston, IL)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
DOE Contract Number:  
FG02-00ER45810
Resource Type:
Patent
Resource Relation:
Patent File Date: 2003-08-21
Country of Publication:
United States
Language:
English

Citation Formats

Stupp, Samuel I., Spoerke, Erik D., Anthony, Shawn G., and Niece, Krista L. Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom. United States: N. p., 2009. Web.
Stupp, Samuel I., Spoerke, Erik D., Anthony, Shawn G., & Niece, Krista L. Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom. United States.
Stupp, Samuel I., Spoerke, Erik D., Anthony, Shawn G., and Niece, Krista L. Tue . "Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom". United States. https://www.osti.gov/servlets/purl/1531589.
@article{osti_1531589,
title = {Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom},
author = {Stupp, Samuel I. and Spoerke, Erik D. and Anthony, Shawn G. and Niece, Krista L.},
abstractNote = {The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {5}
}

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    Works referencing / citing this record:

    Aligned nanofibers and related methods of use
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    Aligned nanofibers and related methods of use
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    Self-assembly of peptide-amphiphile nanofibers under physiological conditions
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    Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
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    Self-assembling peptide amphiphiles and related methods for growth factor delivery
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