Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom

Stupp, Samuel I.; Spoerke, Erik D.; Anthony, Shawn G.; Niece, Krista L.

Title: Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom

Abstract

The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.

Inventors:: Stupp, Samuel I.; Spoerke, Erik D.; Anthony, Shawn G.; Niece, Krista L.

Issue Date:: 2009-05-19

Research Org.:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531589

Patent Number(s):: 7534761

Application Number:: 10/645,304

Assignee:: Northwestern University (Evanston, IL)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K2319/00 - Fusion polypeptide

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S977/795 - Composed of biological material

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K7/08 - having 12 to 20 amino acids
C07K14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

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DOE Contract Number:: FG02-00ER45810

Resource Type:: Patent

Resource Relation:: Patent File Date: 2003-08-21

Country of Publication:: United States

Language:: English

Citation Formats


                    Stupp, Samuel I., Spoerke, Erik D., Anthony, Shawn G., and Niece, Krista L. Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom.  United States: N. p., 2009. 
        Web.

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                    Stupp, Samuel I., Spoerke, Erik D., Anthony, Shawn G., & Niece, Krista L. Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom.  United States.

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                    Stupp, Samuel I., Spoerke, Erik D., Anthony, Shawn G., and Niece, Krista L. Tue .  
        "Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom".  United States.  https://www.osti.gov/servlets/purl/1531589.

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@article{osti_1531589,

  title        = {Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom},

  author       = {Stupp, Samuel I. and Spoerke, Erik D. and Anthony, Shawn G. and Niece, Krista L.},

  abstractNote = {The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2009},

  month        = {5}

}

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Self-assembly and mineralization of peptide-amphiphile nanofibers

Patent Stupp, Samuel I [Chicago, IL]; Hartgerink, Jeffrey D [Pearland, TX]; Beniash, Elia [Auburndale, MA]

Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.
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Title: Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom

Abstract

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Peptide scaffold encapsulation of tissue cells and uses thereof patent-application, October 2002

System and method for computer-based automatic essay scoring patent, January 2001

Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals patent-application, December 2005

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Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core patent, February 1999

Encapsulation of nanotubes via self-assembled nanostructures patent, May 2005

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Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent, September 1997

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent, April 2003

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Poly(amino acid) adhesive tissue grafts patent, March 1998

Derivatives of GLP-1 analogs patent, October 2002

Surface coating spatially controlled patterns patent, February 2005

Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation patent-application, September 2005

Multiblock biodegradable hydrogels for drug delivery and tissue treatment patent, March 2001

Method for synthesizing organoapatites on to surgical metal alloys patent, April 2000

Encapsulation of nanotubes via self-assembled nanostructures patent-application, February 2004

Information retrieval using dynamic evidence combination patent, July 2001

Therapeutic compounds comprised of anti-Fc receptor antibodies patent, August 2001

Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity patent, November 1985

Crosslinked micellar gel composition patent, September 2002

Surfactant peptide nanostructures, and uses thereof patent-application, September 2003

Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents patent, April 2003

Method and system for verifying accuracy of spelling and grammatical composition of a document patent, July 2000

Tissue factor methods and compositions for coagulation and tumor treatment patent, December 2000

Self-assembly and mineralization of peptide-amphiphile nanofibers patent-application, January 2004

Dentifrice patent, July 1992

Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon patent-application, December 2004

Discourse parsing and summarization patent-application, April 2002

Method and system for topical segmentation, segment significance and segment function patent, October 2002

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof patent-application, September 2005

One- or multi-layered layer elements applied to supports and their production patent, May 1993

Differentiation of adipose stromal cells into osteoblasts and uses thereof patent, May 2002

Prophylaxis and therapy of acquired immunodeficiency syndrome patent, July 2001

Self-assembling amphiphiles for construction of peptide secondary structures patent, August 2000

Self-assembling Peptide Amphiphiles and Related Methods for Growth Factor Delivery patent-application, September 2005

Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent-application, January 2004

Surface modifications for enhanced epithelialization patent-application, January 2002

Methods for automated essay analysis patent-application, October 2002

Aligned nanofibers and related methods of use patent, December 2016

Aligned nanofibers and related methods of use patent, July 2014

Heteropeptides useful for reducing nonspecific adsorption patent, March 2014

Peptide-based scaffolds for cartilage regeneration and methods for their use patent, May 2013

Self-assembly and mineralization of peptide-amphiphile nanofibers patent, November 2010

Anti-angiogenic molecules, nanostructures and uses thereof patent, October 2015

Targeted therapy for the prevention of restenosis in the cardiovascular system patent, December 2016

Peptide amphiphiles having improved solubility and methods of using same patent, December 2011

Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent, June 2010

Self-assembling peptide amphiphiles and related methods for growth factor delivery patent, March 2012

Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent, November 2011

Composition and method for self-assembly and mineralization of peptide-amphiphiles patent, February 2012

Synthesis and self-assembly of ABC triblock bola peptide amphiphiles patent, March 2010

Self-assembling peptide amphiphiles and related methods for growth factor delivery patent, November 2013

Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use patent, December 2010

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patent-application, October 2002

System and method for computer-based automatic essay scoring
patent, January 2001

Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
patent-application, December 2005

Block copolymers for multifunctional self-assembled systems
patent-application, March 2003

Amphiphilic macrocyclic derivatives and their analogues
patent-application, May 2003

Differentiation of human embryonic germ cells
patent, May 2003

Primate embryonic stem cells
patent, December 1998

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
patent, October 2004

Methods and compositions for encapsulation of cells
patent-application, November 2006

Process for nucleation of ceramics and product thereof
patent, November 1999

Composition and method for self-assembly and mineralizatin of peptide amphiphiles
patent-application, July 2006

Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
patent, February 1999

Encapsulation of nanotubes via self-assembled nanostructures
patent, May 2005

Information processing expert system for text analysis and predicting public opinion based information available to the public
patent, May 1990

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
patent, September 1997

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
patent, April 2003

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
patent, September 1999

Poly(amino acid) adhesive tissue grafts
patent, March 1998

Derivatives of GLP-1 analogs
patent, October 2002

Surface coating spatially controlled patterns
patent, February 2005

Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
patent-application, September 2005

Multiblock biodegradable hydrogels for drug delivery and tissue treatment
patent, March 2001

Method for synthesizing organoapatites on to surgical metal alloys
patent, April 2000

Encapsulation of nanotubes via self-assembled nanostructures
patent-application, February 2004

Information retrieval using dynamic evidence combination
patent, July 2001

Therapeutic compounds comprised of anti-Fc receptor antibodies
patent, August 2001

Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
patent, November 1985

Crosslinked micellar gel composition
patent, September 2002

Surfactant peptide nanostructures, and uses thereof
patent-application, September 2003

Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
patent, April 2003

Method and system for verifying accuracy of spelling and grammatical composition of a document
patent, July 2000

Tissue factor methods and compositions for coagulation and tumor treatment
patent, December 2000

Self-assembly and mineralization of peptide-amphiphile nanofibers
patent-application, January 2004

Dentifrice
patent, July 1992

Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
patent-application, December 2004

Discourse parsing and summarization
patent-application, April 2002

Method and system for topical segmentation, segment significance and segment function
patent, October 2002

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
patent-application, September 2005

One- or multi-layered layer elements applied to supports and their production
patent, May 1993

Differentiation of adipose stromal cells into osteoblasts and uses thereof
patent, May 2002

Prophylaxis and therapy of acquired immunodeficiency syndrome
patent, July 2001

Self-assembling amphiphiles for construction of peptide secondary structures
patent, August 2000

Self-assembling Peptide Amphiphiles and Related Methods for Growth Factor Delivery
patent-application, September 2005

Self-assembly of peptide-amphiphile nanofibers under physiological conditions
patent-application, January 2004

Surface modifications for enhanced epithelialization
patent-application, January 2002

Methods for automated essay analysis
patent-application, October 2002

Aligned nanofibers and related methods of use
patent, December 2016

Aligned nanofibers and related methods of use
patent, July 2014

Heteropeptides useful for reducing nonspecific adsorption
patent, March 2014

Peptide-based scaffolds for cartilage regeneration and methods for their use
patent, May 2013

Self-assembly and mineralization of peptide-amphiphile nanofibers
patent, November 2010

Anti-angiogenic molecules, nanostructures and uses thereof
patent, October 2015

Targeted therapy for the prevention of restenosis in the cardiovascular system
patent, December 2016

Peptide amphiphiles having improved solubility and methods of using same
patent, December 2011

Self-assembly of peptide-amphiphile nanofibers under physiological conditions
patent, June 2010

Self-assembling peptide amphiphiles and related methods for growth factor delivery
patent, March 2012

Self-assembly of peptide-amphiphile nanofibers under physiological conditions
patent, November 2011

Composition and method for self-assembly and mineralization of peptide-amphiphiles
patent, February 2012

Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
patent, March 2010

Self-assembling peptide amphiphiles and related methods for growth factor delivery
patent, November 2013

Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use
patent, December 2010