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Title: Automatic cryoloop alignment for protein crystals

Abstract

Methods and apparatus for implementing robust and efficient cryoloop auto-centering for crystal location and alignment to the x-ray beam are provided. Image processing techniques are used for recognition of the small protein crystals. The detected crystal location enables crystal positioning in the x-ray beam, and optimization of the x-ray optics such as beam profile and intensity to the size and shape of the protein crystals.

Inventors:
;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531569
Patent Number(s):
7438472
Application Number:
11/774,679
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C30 - CRYSTAL GROWTH C30B - SINGLE-CRYSTAL-GROWTH
DOE Contract Number:  
AC02-06CH11357; W-31-109-ENG-38
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007-07-09
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS

Citation Formats

Lazarski, Krzysztof Z., and Joachimiak, Andrzej. Automatic cryoloop alignment for protein crystals. United States: N. p., 2008. Web.
Lazarski, Krzysztof Z., & Joachimiak, Andrzej. Automatic cryoloop alignment for protein crystals. United States.
Lazarski, Krzysztof Z., and Joachimiak, Andrzej. Tue . "Automatic cryoloop alignment for protein crystals". United States. https://www.osti.gov/servlets/purl/1531569.
@article{osti_1531569,
title = {Automatic cryoloop alignment for protein crystals},
author = {Lazarski, Krzysztof Z. and Joachimiak, Andrzej},
abstractNote = {Methods and apparatus for implementing robust and efficient cryoloop auto-centering for crystal location and alignment to the x-ray beam are provided. Image processing techniques are used for recognition of the small protein crystals. The detected crystal location enables crystal positioning in the x-ray beam, and optimization of the x-ray optics such as beam profile and intensity to the size and shape of the protein crystals.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {10}
}

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Works referenced in this record:

Integrated crystal mounting and alignment system for high-throughput biological crystallography
patent, September 2007


Automated sample handling for X-ray crystallography
patent, June 2002


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