Analyte sensing mediated by adapter/carrier molecules
Abstract
This invention relates to an improved method and system for sensing of one or more analytes. A host molecule, which serves as an adapter/carrier, is used to facilitate interaction between the analyte and the sensor element. A detectable signal is produced reflecting the identity and concentration of analyte present.
- Inventors:
- Issue Date:
- Research Org.:
- Texas A&M Univ., College Station, TX (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531495
- Patent Number(s):
- 6927070
- Application Number:
- 10/180,792
- Assignee:
- The Texas A&M University System (College Station, TX)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2002-06-25
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Bayley, Hagan, Braha, Orit, and Gu, LiQun. Analyte sensing mediated by adapter/carrier molecules. United States: N. p., 2005.
Web.
Bayley, Hagan, Braha, Orit, & Gu, LiQun. Analyte sensing mediated by adapter/carrier molecules. United States.
Bayley, Hagan, Braha, Orit, and Gu, LiQun. Tue .
"Analyte sensing mediated by adapter/carrier molecules". United States. https://www.osti.gov/servlets/purl/1531495.
@article{osti_1531495,
title = {Analyte sensing mediated by adapter/carrier molecules},
author = {Bayley, Hagan and Braha, Orit and Gu, LiQun},
abstractNote = {This invention relates to an improved method and system for sensing of one or more analytes. A host molecule, which serves as an adapter/carrier, is used to facilitate interaction between the analyte and the sensor element. A detectable signal is produced reflecting the identity and concentration of analyte present.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {8}
}
Works referenced in this record:
Polarized external infrared reflection-absorption spectrometry at the air/water interface: Comparison of experimental and theoretical results for different angles of incidence
journal, March 1993
- Gericke, Arne; Michailov, Alexander V.; Hühnerfuss, Heinrich
- Vibrational Spectroscopy, Vol. 4, Issue 3
Monitoring of phospholipid monolayer hydrolysis by phospholipase A2 by use of polarization-modulated Fourier transform infrared spectroscopy
journal, December 2000
- Grandbois, Michel; Desbat, Bernard; Salesse, Christian
- Biophysical Chemistry, Vol. 88, Issue 1-3
Molecular recognition at surfaces derivatized with self-assembled monolayers
patent, April 1997
- Bamdad, Cynthia; Sigal, George; Strominger, Jack L.
- US Patent Document 5,620,850
Highly sensitive multichannel spectrometer for subpicosecond spectroscopy in the midinfrared
journal, January 1994
- Hamm, P.; Wiemann, S.; Zurek, M.
- Optics Letters, Vol. 19, Issue 20
The interfacial structure of phospholipid monolayer films: an infrared reflectance study
journal, December 1989
- Hunt, Rodney D.; Mitchell, Melody L.; Dluhy, Richard A.
- Journal of Molecular Structure, Vol. 214
Anisotropic Optical Constants of Bacteriorhodopsin in the Mid-Infrared: Consequence on the Determination of α-Helix Orientation
journal, October 1999
- Blaudez, D.; Boucher, F.; Buffeteau, T.
- Applied Spectroscopy, Vol. 53, Issue 10
Arrays of materials attached to a substrate
patent, April 1998
- Fodor, Stephen P. A.; Stryer, Lubert; Read, J. Leighton
- US Patent Document 5,744,305
Improved IRRAS Apparatus for Studies of Aqueous Monolayer Films: Determination of the Orientation of Each Chain in a Fatty-Acid Homogeneous Ceramide 2
journal, August 2001
- Flach, Carol R.; Xu, Zhi; Bi, Xiaohong
- Applied Spectroscopy, Vol. 55, Issue 8
Characterization and Application of an Infrared Linear Array Spectrometer for Time-Resolved Infrared Spectroscopy
journal, October 1993
- Alawi, Sadiq M.; Krug, Teresa; Richardson, Hugh H.
- Applied Spectroscopy, Vol. 47, Issue 10
Optical Constant Determination in the Infrared of Uniaxially Oriented Monolayers from Transmittance and Reflectance Measurements
journal, June 1999
- Buffeteau, T.; Blaudez, D.; Péré, E.
- The Journal of Physical Chemistry B, Vol. 103, Issue 24
Palmitoylation of lung surfactant protein SP-C alters surface thermodynamics, but not protein secondary structure or orientation in 1,2-dipalmitoylphosphatidylcholine Langmuir films
journal, January 1999
- Flach, Carol R.; Gericke, Arne; Keough, Kevin M. W.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1416, Issue 1-2
Spatially-addressable immobilization of anti-ligands on surfaces
patent, October 1993
- Barrett, Ronald W.; Pirrung, Michael C.; Stryer, Lubert
- US Patent Document 5,252,743
Multiplexed molecular analysis apparatus and method
patent, July 2000
- Balch, William J.
- US Patent Document 6,083,763
Interpretation of Reflection and Transmission Spectra for Thin Films: Reflection
journal, July 1994
- Yamamoto, Kiyoshi; Ishida, Hatsuo
- Applied Spectroscopy, Vol. 48, Issue 7
Polarization-Modulated Infrared Reflection Absorption Spectroscopy Measurement of Phospholipid Monolayer Hydrolysis by Phospholipase C
journal, September 1999
- Grandbois, Michel; Desbat, Bernard; Blaudez, Daniel
- Langmuir, Vol. 15, Issue 19
Molecular Orientation in Langmuir Films of 12-Hydroxystearic Acid Studied by Infrared External-Reflection Spectroscopy
journal, October 1998
- Sakai, H.; Umemura, J.
- Langmuir, Vol. 14, Issue 21
In situ FT-IR investigation of phospholipid monolayer phase transitions at the air water interface
journal, February 1988
- Mitchell, Melody L.; Dluhy, Richard A.
- Journal of the American Chemical Society, Vol. 110, Issue 3
Infrared and Raman spectroscopies of monolayers at the air–water interface
journal, August 1999
- Blaudez, Daniel; Buffeteau, Thierry; Desbat, Bernard
- Current Opinion in Colloid & Interface Science, Vol. 4, Issue 4
Novel All-fibre-optic Fourier-transform Spectrometer with Thermally Scanned Interferometer
book, January 1997
- Stelzle, M.; Tuchtenhagen, J.; Rabolt, J. F.
- Progress in Fourier Transform Spectroscopy
Infrared spectroscopic investigations of pulmonary surfactant. Surface film transitions at the air-water interface and bulk phase thermotropism
journal, December 1989
- Dluhy, R. A.; Reilly, K. E.; Hunt, R. D.
- Biophysical Journal, Vol. 56, Issue 6
Anisotropic Optical Constants of α-Helix and β-Sheet Secondary Structures in the Infrared
journal, May 2000
- Buffeteau, T.; Le Calvez, E.; Castano, S.
- The Journal of Physical Chemistry B, Vol. 104, Issue 18
Study by infrared spectroscopy of the conformation of dipalmitoylphosphatidylglycerol monolayers at the air–water interface and transferred on solid substrates
journal, November 1998
- Dicko, Awa; Bourque, Hélène; Pézolet, Michel
- Chemistry and Physics of Lipids, Vol. 96, Issue 1-2
Cell-targeted lytic pore-forming agents
patent, October 1998
- Bayley, Hagen; Walker, Barbara J.
- US Patent Document 5,817,771
Partial Chain Deuteration as an IRRAS Probe of Conformational Order of Different Regions in Hexadecanoic Acid Monolayers at the Air/Water Interface
journal, January 1996
- Gericke, Arne; Mendelsohn, Richard
- Langmuir, Vol. 12, Issue 3
External Infrared Reflection Absorption Spectrometry of Monolayer Films at the Air-Water Interface
journal, October 1995
- Mendelsohn, Richard; Brauner, Joseph W.; Gericke, Arne
- Annual Review of Physical Chemistry, Vol. 46, Issue 1
Cell-targeted lytic pore-forming agents
patent, October 1998
- Bayley, Hagen; Walker, Barbara J.
- US Patent Document 5,824,776
Molecular orientation in thin monolayer films by infrared spectroscopy
journal, January 1983
- Rabolt, J. F.; Burns, F. C.; Schlotter, N. E.
- Journal of Electron Spectroscopy and Related Phenomena, Vol. 30, Issue 1
Structure and orientation of lung surfactant SP-C and L-alpha-dipalmitoylphosphatidylcholine in aqueous monolayers
journal, July 1997
- Gericke, A.; Flach, C. R.; Mendelsohn, R.
- Biophysical Journal, Vol. 73, Issue 1
A Novel Infrared Spectrometer Using a Linear Array Detector
journal, June 1990
- Richardson, Hugh H.; Pabst, Vernon W.; Butcher, Jared A.
- Applied Spectroscopy, Vol. 44, Issue 5
Phase Transitions in Monolayers
journal, October 1992
- Knobler, C. M.; Desai, R. C.
- Annual Review of Physical Chemistry, Vol. 43, Issue 1
Quantitative Determination of Molecular Chain Tilt Angles in Monolayer Films at the Air/Water Interface: Infrared Reflection/Absorption Spectroscopy of Behenic Acid Methyl Ester
journal, January 1997
- Flach, Carol R.; Gericke, Arne; Mendelsohn, Richard
- The Journal of Physical Chemistry B, Vol. 101, Issue 1
Multichannel Fourier Transform Raman Spectroscopy: Combining the Advantages of CCDs with Interferometry
journal, September 1996
- Zhao, Jun; McCreery, Richard L.
- Applied Spectroscopy, Vol. 50, Issue 9
Optical theory applied to infrared spectroscopy
journal, November 1994
- Yamamoto, Kiyoshi; Ishida, Hatsuo
- Vibrational Spectroscopy, Vol. 8, Issue 1
Design and Performance of a Planar Array Infrared Spectrograph That Operates in the 3400 to 2000 cm −1 Region
journal, February 2002
- Elmore, Douglas L.; Tsao, Mei-Wei; Frisk, Simon
- Applied Spectroscopy, Vol. 56, Issue 2
Quantitative external reflection infrared spectroscopic analysis of insoluble monolayers spread at the air-water interface
journal, March 1986
- Dluhy, Richard A.
- The Journal of Physical Chemistry, Vol. 90, Issue 7
Calcium ion interactions with insoluble phospholipid monolayer films at the A/W interface. External reflection-absorption IR studies
journal, November 1993
- Flach, C. R.; Brauner, J. W.; Mendelsohn, R.
- Biophysical Journal, Vol. 65, Issue 5
Vibrational spectra in the CH stretching region and the structure of the polymethylene chain
journal, January 1978
- Snyder, R. G.; Hsu, S. L.; Krimm, S.
- Spectrochimica Acta Part A: Molecular Spectroscopy, Vol. 34, Issue 4
Works referencing / citing this record:
High temperature ion channels and pores
patent, January 2011
- Kang, Xiaofeng; Gu, Li-Qun; Cheley, Stephen
- US Patent Document 7,867,716
Stochastic sensing through covalent interactions
patent, March 2013
- Bayley, Hagan; Shin, Seong-Ho; Luchian, Tudor
- US Patent Document 8,404,449
Method for sequencing a heteropolymeric target nucleic acid sequence
patent, August 2017
- Stoddart, David Jackson; Heron, Andrew John; Maglia, Giovanni
- US Patent Document 9,732,381
Enzyme stalling method
patent, March 2019
- Heron, Andrew John; Alves, David Antoni; Clarke, James Anthony
- US Patent Document 10,221,450
Mutant lysenin pores
patent, October 2017
- Bruce, Mark; Clarke, James Anthony; Heron, Andrew John
- US Patent Document 9,777,049
Enzyme-pore constructs
patent, February 2018
- Jayasinghe, Lakmal; Bayley, John Hagan Pryce; Cheley, Stephen
- US Patent Document 9,885,078
DNA sequencing and amplification systems using nanoscale field effect sensor arrays
patent, February 2015
- Bashir, Rashid; Alam, Ashraf; Akin, Demir
- US Patent Document 8,945,912
Label free detection of nucleic acid amplification
patent, June 2016
- Bashir, Rashid; Liu, Yi-Shao; Salm, Eric
- US Patent Document 9,376,713
Methods of enhancing translocation of charged analytes through transmembrane protein pores
patent, February 2017
- Maglia, Giovanni; Bayley, John Hagan Pryce
- US Patent Document 9,562,887
Molecular adaptors
patent, September 2014
- Bayley, John Hagan Pryce; Wu, Haichen; Maglia, Giovanni
- US Patent Document 8,822,160
Mutant pores
patent, January 2019
- Clarke, James Anthony; Heron, Andrew John; Jayasinghe, Lakmal
- US Patent Document 10,167,503
Microfabrication methods for the optimal patterning of substrates
patent, June 2017
- Lebl, Michal; Heiner, David L.; Zhao, Chanfeng
- US Patent Document 9,677,194
Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
patent, May 2018
- Brown, Clive Gavin; Clarke, James Anthony; Hall, Graham
- US Patent Document 9,957,560
Nanopore biosensors for detection of proteins and nucleic acids
patent, June 2018
- Maglia, Giovanni; Soskine, Mikhael
- US Patent Document 10,006,905
Methods using pores
patent, July 2014
- Bayley, Hagan; Astier, Yann; Braha, Orit
- US Patent Document 8,785,211
Mutant pores
patent, September 2017
- Clarke, James Anthony; Heron, Andrew John; Jayasinghe, Lakmal
- US Patent Document 9,751,915
Base-detecting pore
patent, September 2016
- Clarke, James Anthony; Jayasinghe, Lakmal; Reid, Terence Alan
- US Patent Document 9,447,152
Label-free biomolecule sensor based on surface charge modulated ionic conductance
patent, December 2014
- Smirnov, Sergei; Wang, Xian
- US Patent Document 8,906,609
Enzyme-pore constructs
patent, September 2018
- Jayasinghe, Lakmal; Bayley, John Hagan Pryce; Cheley, Stephen
- US Patent Document 10,077,471