skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Encapsulating particles with coatings that conform to size and shape of the particles

Abstract

Particles such as islet cells are encapsulated by a method that forms a coating of uniform thickness that conforms to the size and shape of the particles. Two substantially immiscible liquids of different densities are provided in a container as upper and lower liquids such that an interface exists between the liquids. The upper liquid is less dense and has a greater viscosity than the lower liquid which is a coating liquid containing particles to be encapsulated. A tube is positioned in the upper liquid such that an orifice of the tube is above the interface. A pump connected to the tube sucks liquid through the tube at a rate sufficient to form a spout containing substantially the lower liquid extending between the interface and the tube orifice. The spout has maximum diameter at the interface and decreases in diameter as the spout approaches the tube orifice. Particles in the lower liquid are drawn up through the spout as liquid is withdrawn, and coated particles are released from the spout at a point where the diameter of the spout is less than the diameter of the particles, and the coated particles flow through the tube. The coating liquid may bemore » a pre-polymer that can be polymerized and crosslinked after coating. The coated particles have therapeutic applications such as administering coated islet cells to treat diabetes.« less

Inventors:
; ; ;
Issue Date:
Research Org.:
Arch Development, Corp., Chicago, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531456
Patent Number(s):
6558665
Application Number:
09/575,844
Assignee:
Arch Development Corporation (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-92ER25119
Resource Type:
Patent
Resource Relation:
Patent File Date: 2000-05-18
Country of Publication:
United States
Language:
English

Citation Formats

Cohen, Itai, Nagel, Sidney, Rilo, Horacio, and Mrksich, Milan. Encapsulating particles with coatings that conform to size and shape of the particles. United States: N. p., 2003. Web.
Cohen, Itai, Nagel, Sidney, Rilo, Horacio, & Mrksich, Milan. Encapsulating particles with coatings that conform to size and shape of the particles. United States.
Cohen, Itai, Nagel, Sidney, Rilo, Horacio, and Mrksich, Milan. Tue . "Encapsulating particles with coatings that conform to size and shape of the particles". United States. https://www.osti.gov/servlets/purl/1531456.
@article{osti_1531456,
title = {Encapsulating particles with coatings that conform to size and shape of the particles},
author = {Cohen, Itai and Nagel, Sidney and Rilo, Horacio and Mrksich, Milan},
abstractNote = {Particles such as islet cells are encapsulated by a method that forms a coating of uniform thickness that conforms to the size and shape of the particles. Two substantially immiscible liquids of different densities are provided in a container as upper and lower liquids such that an interface exists between the liquids. The upper liquid is less dense and has a greater viscosity than the lower liquid which is a coating liquid containing particles to be encapsulated. A tube is positioned in the upper liquid such that an orifice of the tube is above the interface. A pump connected to the tube sucks liquid through the tube at a rate sufficient to form a spout containing substantially the lower liquid extending between the interface and the tube orifice. The spout has maximum diameter at the interface and decreases in diameter as the spout approaches the tube orifice. Particles in the lower liquid are drawn up through the spout as liquid is withdrawn, and coated particles are released from the spout at a point where the diameter of the spout is less than the diameter of the particles, and the coated particles flow through the tube. The coating liquid may be a pre-polymer that can be polymerized and crosslinked after coating. The coated particles have therapeutic applications such as administering coated islet cells to treat diabetes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {5}
}

Patent:

Save / Share:

Works referenced in this record:

    Works referencing / citing this record:

    Flow regulating stopcocks and related methods
    patent, April 2013


    Crosslinkable macromers
    patent, June 2009


    Infusion pump system with disposable cartridge having pressure venting and pressure feedback
    patent, December 2015


    Methods and compositions for treatment of ion imbalances
    patent, August 2010


    Ion binding polymers and uses thereof
    patent, July 2013


    Method for manufacture of macrobeads
    patent, July 2015


    Encapsulation microfluidic device
    patent, August 2017


    Infusion pump system with disposable cartridge having pressure venting and pressure feedback
    patent, January 2015


    Apparatus and method for encapsulating pancreatic cells
    patent, January 2012


    Ion binding compositions
    patent, June 2012


    Anomaly detection based on signal variations
    patent, January 2006


    Two chamber pumps and related methods
    patent, March 2015


    Encapsulating cells and lumen
    patent, December 2011


    System and method for detecting occlusions in an infusion pump
    patent, May 2018


    Direct coating solid dosage forms using powdered materials
    patent, April 2012


    Amphiphilic polymer capsules and related methods of interfacial assembly
    patent, August 2011


    Infusion pump system with disposable cartridge having pressure venting and pressure feedback
    patent, October 2012


    Direct coating solid dosage forms using powdered materials
    patent, January 2011


    Methods and compositions for diagnosing disease
    patent, December 2015


    Ion binding compositions
    patent, October 2012


    Amphiphilic polymer capsules and related methods of interfacial assembly
    patent, December 2010


    Amphiphilic polymer capsules and related methods of interfacial assembly
    patent, October 2009


    Methods and compositions for treatment of ion imbalances
    patent, April 2013