Title: Encapsulating particles with coatings that conform to size and shape of the particles

Abstract

Particles such as islet cells are encapsulated by a method that forms a coating of uniform thickness that conforms to the size and shape of the particles. Two substantially immiscible liquids of different densities are provided in a container as upper and lower liquids such that an interface exists between the liquids. The upper liquid is less dense and has a greater viscosity than the lower liquid which is a coating liquid containing particles to be encapsulated. A tube is positioned in the upper liquid such that an orifice of the tube is above the interface. A pump connected to the tube sucks liquid through the tube at a rate sufficient to form a spout containing substantially the lower liquid extending between the interface and the tube orifice. The spout has maximum diameter at the interface and decreases in diameter as the spout approaches the tube orifice. Particles in the lower liquid are drawn up through the spout as liquid is withdrawn, and coated particles are released from the spout at a point where the diameter of the spout is less than the diameter of the particles, and the coated particles flow through the tube. The coating liquid may bemore » a pre-polymer that can be polymerized and crosslinked after coating. The coated particles have therapeutic applications such as administering coated islet cells to treat diabetes. « less

Inventors:

Cohen, Itai; Nagel, Sidney; Rilo, Horacio; Mrksich, Milan

Issue Date:

2003-05-06

Research Org.:

Arch Development, Corp., Chicago, IL (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1531456

Patent Number(s):

6558665

Application Number:

09/575,844

Assignee:

Arch Development Corporation (Chicago, IL)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K35/12 - Materials from mammals
A61K9/5031 - {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly
A61K9/5089 - {Processes}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J13/04 - by physical processes, e.g. drying, spraying
B01J13/14 - Polymerisation

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N11/089 - obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C12N11/098 - formed in the presence of the enzymes or microbial cells
C12N11/10 - the carrier being a carbohydrate
C12N5/0676 - {Pancreatic cells}

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DOE Contract Number:  

FG02-92ER25119

Resource Type:

Patent

Resource Relation:

Patent File Date: 2000-05-18

Country of Publication:

United States

Language:

English