Surface-bound, double-stranded DNA protein arrays
Abstract
The invention provides a synthetic array of surface-bound, bimolecular, double-stranded nucleic acid molecules, the array comprising a solid support and a plurality of bimolecular double-stranded nucleic acid molecule members, a member comprising a first nucleic acid strand linked to the solid support and a second nucleic acid strand which is substantially complementary to the first strand and complexed to the first strand by Watson-Crick base pairing, wherein for at least a portion of the members, each member comprises a recognition site within a nucleic acid sequence for a protein, wherein a recognition site within a nucleic acid sequence for a protein of a first member is different from a recognition site within a nucleic acid sequence for a protein of a second member and wherein a protein is bound to a member thereof.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard College, Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1531453
- Patent Number(s):
- 6,548,021
- Application Number:
- 09/132,368
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- DOE Contract Number:
- FG02-87ER60565
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 1998-08-11
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Church, George M., and Bulyk, Martha L. Surface-bound, double-stranded DNA protein arrays. United States: N. p., 2003.
Web.
Church, George M., & Bulyk, Martha L. Surface-bound, double-stranded DNA protein arrays. United States.
Church, George M., and Bulyk, Martha L. Tue .
"Surface-bound, double-stranded DNA protein arrays". United States. https://www.osti.gov/servlets/purl/1531453.
@article{osti_1531453,
title = {Surface-bound, double-stranded DNA protein arrays},
author = {Church, George M. and Bulyk, Martha L.},
abstractNote = {The invention provides a synthetic array of surface-bound, bimolecular, double-stranded nucleic acid molecules, the array comprising a solid support and a plurality of bimolecular double-stranded nucleic acid molecule members, a member comprising a first nucleic acid strand linked to the solid support and a second nucleic acid strand which is substantially complementary to the first strand and complexed to the first strand by Watson-Crick base pairing, wherein for at least a portion of the members, each member comprises a recognition site within a nucleic acid sequence for a protein, wherein a recognition site within a nucleic acid sequence for a protein of a first member is different from a recognition site within a nucleic acid sequence for a protein of a second member and wherein a protein is bound to a member thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {4}
}