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Title: Treatment and detection of tuberculosis, leprosy, and related diseases

Abstract

Method for treatment of an infection in an animal or plant by an organism having a non-discriminating DNA polymerase. The organism is contacted with a therapeutically effective amount of a dideoxynucleoside or dideoxynucleotide in a pharmaceutically acceptable buffer. Such contact reduces the infection or a symptom of the infection in the animal or plant.

Inventors:
;
Issue Date:
Research Org.:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531423
Patent Number(s):
5776673
Application Number:
08/427,072
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG02-88ER60688
Resource Type:
Patent
Resource Relation:
Patent File Date: 1995-04-21
Country of Publication:
United States
Language:
English

Citation Formats

Tabor, Stanley, and Richardson, Charles C. Treatment and detection of tuberculosis, leprosy, and related diseases. United States: N. p., 1998. Web.
Tabor, Stanley, & Richardson, Charles C. Treatment and detection of tuberculosis, leprosy, and related diseases. United States.
Tabor, Stanley, and Richardson, Charles C. Tue . "Treatment and detection of tuberculosis, leprosy, and related diseases". United States. https://www.osti.gov/servlets/purl/1531423.
@article{osti_1531423,
title = {Treatment and detection of tuberculosis, leprosy, and related diseases},
author = {Tabor, Stanley and Richardson, Charles C.},
abstractNote = {Method for treatment of an infection in an animal or plant by an organism having a non-discriminating DNA polymerase. The organism is contacted with a therapeutically effective amount of a dideoxynucleoside or dideoxynucleotide in a pharmaceutically acceptable buffer. Such contact reduces the infection or a symptom of the infection in the animal or plant.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {7}
}

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Works referenced in this record:

Tuberculosis: The Return of an Old Enemy
journal, January 1993


Effects of 2?,3?-dideoxynucleosides on mammalian cells and viruses
journal, November 1984


Dideoxycytidine: Current clinical experience and future prospects
journal, May 1990


Involvement of DNA polymerase alpha in simian virus 40 DNA replication.
journal, May 1978


Selective Inactivation of the Exonuclease Activity of Bacteriophage T7 DNA Polymerase by in Vitro Mutagenesis
journal, April 1989


Role of DNA polymerase γ in adenovirus DNA replication
journal, November 1978


Compilation, alignment, and phylogenetic relationships of DNA polymerases
journal, January 1993


Zalcitabine and didanosine
journal, January 1993


Safety and tolerance of dideoxycytidine as a single agent
journal, May 1990


Leprosy, tuberculosis, and the new genetics.
journal, January 1993


An attempt to unify the structure of polymerases
journal, January 1990


Tuberculosis: Commentary on a Reemergent Killer
journal, August 1992


Treatment and Prevention of Tuberculosis in Hiv-Infected Persons
journal, June 1994


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