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Title: Molecular sleds and uses thereof

Abstract

The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
The Broad Institute, Inc., Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States); Rijksuniversiteit Groningen (Netherlands)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531360
Patent Number(s):
10065989
Application Number:
14/595,941
Assignee:
The Broad Institute, Inc. (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA); Rijksuniversiteit Groningen (Groningen, CH)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015-01-13
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Mangel, Walter F., Blainey, Paul C., Graziano, Vito, Herrmann, Andreas, McGrath, William J., Van Oijen, Antonius Martinus, and Xie, Xiaoliang Sunney. Molecular sleds and uses thereof. United States: N. p., 2018. Web.
Mangel, Walter F., Blainey, Paul C., Graziano, Vito, Herrmann, Andreas, McGrath, William J., Van Oijen, Antonius Martinus, & Xie, Xiaoliang Sunney. Molecular sleds and uses thereof. United States.
Mangel, Walter F., Blainey, Paul C., Graziano, Vito, Herrmann, Andreas, McGrath, William J., Van Oijen, Antonius Martinus, and Xie, Xiaoliang Sunney. Tue . "Molecular sleds and uses thereof". United States. https://www.osti.gov/servlets/purl/1531360.
@article{osti_1531360,
title = {Molecular sleds and uses thereof},
author = {Mangel, Walter F. and Blainey, Paul C. and Graziano, Vito and Herrmann, Andreas and McGrath, William J. and Van Oijen, Antonius Martinus and Xie, Xiaoliang Sunney},
abstractNote = {The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 04 00:00:00 EDT 2018},
month = {Tue Sep 04 00:00:00 EDT 2018}
}

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