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Title: Molecular sleds and uses thereof

Abstract

The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
The Broad Institute, Inc., Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States); Rijksuniversiteit Groningen (Netherlands)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531360
Patent Number(s):
10065989
Application Number:
14/595,941
Assignee:
The Broad Institute, Inc. (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA); Rijksuniversiteit Groningen (Groningen, CH)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015-01-13
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Mangel, Walter F., Blainey, Paul C., Graziano, Vito, Herrmann, Andreas, McGrath, William J., Van Oijen, Antonius Martinus, and Xie, Xiaoliang Sunney. Molecular sleds and uses thereof. United States: N. p., 2018. Web.
Mangel, Walter F., Blainey, Paul C., Graziano, Vito, Herrmann, Andreas, McGrath, William J., Van Oijen, Antonius Martinus, & Xie, Xiaoliang Sunney. Molecular sleds and uses thereof. United States.
Mangel, Walter F., Blainey, Paul C., Graziano, Vito, Herrmann, Andreas, McGrath, William J., Van Oijen, Antonius Martinus, and Xie, Xiaoliang Sunney. Tue . "Molecular sleds and uses thereof". United States. https://www.osti.gov/servlets/purl/1531360.
@article{osti_1531360,
title = {Molecular sleds and uses thereof},
author = {Mangel, Walter F. and Blainey, Paul C. and Graziano, Vito and Herrmann, Andreas and McGrath, William J. and Van Oijen, Antonius Martinus and Xie, Xiaoliang Sunney},
abstractNote = {The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {9}
}

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Works referenced in this record:

Cell Penetrating Peptides for In Vivo Molecular Imaging Applications
journal, August 2008


In the Virion, the 11-Amino-Acid Peptide Cofactor pVIc Is Covalently Linked to the Adenovirus Proteinase
journal, May 2002


Human Adenovirus Proteinase:  DNA Binding and Stimulation of Proteinase Activity by DNA
journal, November 2001


Cationic Oligonucleotide−Peptide Conjugates with Aggregating Properties Enter Efficiently into Cells while Maintaining Hybridization Properties and Enzymatic Recognition
journal, August 2006


Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins
journal, May 2009


Peptide-mediated protein delivery—Which pathways are penetrable?
journal, December 2010


Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease
journal, November 2004


Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
journal, August 2008


Membrane-permeable arginine-rich peptides and the translocation mechanisms
journal, February 2005


Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer
journal, February 2011


Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly
journal, January 2005


Nucleic acids encoding fusion peptides
patent, March 2008


Biotechnological applications of cyclodextrins
journal, December 2002


Peptide-Based Matrices as Drug Delivery Vehicles
journal, March 2010


Single-Molecule Studies of Adenovirus Maturation
journal, January 2013


Protein delivery using engineered virus-like particles
journal, September 2011


Toxicology and Drug Delivery by Cucurbit[n]uril Type Molecular Containers
journal, May 2010