Title: Molecular sleds and uses thereof

Abstract

The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Inventors:

Mangel, Walter F.; Blainey, Paul C.; Graziano, Vito; Herrmann, Andreas; McGrath, William J.; Van Oijen, Antonius Martinus; Xie, Xiaoliang Sunney

Issue Date:

2018-09-04

Research Org.:

The Broad Institute, Inc., Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States); Rijksuniversiteit Groningen (Netherlands)

Sponsoring Org.:

USDOE

OSTI Identifier:

1531360

Patent Number(s):

10065989

Application Number:

14/595,941

Assignee:

The Broad Institute, Inc. (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA); Rijksuniversiteit Groningen (Groningen, CH)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K31/4375 - the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K31/4709 - Non-condensed quinolines and containing further heterocyclic rings
A61K31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61K31/713 - Double-stranded nucleic acids or oligonucleotides
A61K47/645 - {Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT}
A61K47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/04 - Antibacterial agents

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K4/00 - Peptides having up to 20 amino acids in an undefined or only partially defined sequence

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

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Resource Type:

Patent

Resource Relation:

Patent File Date: 2015-01-13

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES