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Title: Compositions and methods for the delivery of oxygen

Abstract

H--NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H--NOX proteins comprise mutations that impart altered O.sub.2 or NO ligand-binding relative to the corresponding wild-type H--NOX domain, and are operative as physiologically compatible mammalian blood O.sub.2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H--NOX proteins for the treatment of any condition for which delivery of O.sub.2 is beneficial.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1502841
Patent Number(s):
10202428
Application Number:
15/292,012
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Oct 12
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Cary, Stephen P. L., Boon, Elizabeth M., Weinert, Emily, Winger, Jonathan A., and Marletta, Michael A. Compositions and methods for the delivery of oxygen. United States: N. p., 2019. Web.
Cary, Stephen P. L., Boon, Elizabeth M., Weinert, Emily, Winger, Jonathan A., & Marletta, Michael A. Compositions and methods for the delivery of oxygen. United States.
Cary, Stephen P. L., Boon, Elizabeth M., Weinert, Emily, Winger, Jonathan A., and Marletta, Michael A. Tue . "Compositions and methods for the delivery of oxygen". United States. https://www.osti.gov/servlets/purl/1502841.
@article{osti_1502841,
title = {Compositions and methods for the delivery of oxygen},
author = {Cary, Stephen P. L. and Boon, Elizabeth M. and Weinert, Emily and Winger, Jonathan A. and Marletta, Michael A.},
abstractNote = {H--NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H--NOX proteins comprise mutations that impart altered O.sub.2 or NO ligand-binding relative to the corresponding wild-type H--NOX domain, and are operative as physiologically compatible mammalian blood O.sub.2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H--NOX proteins for the treatment of any condition for which delivery of O.sub.2 is beneficial.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {2}
}

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