Title: Compositions and methods for the delivery of oxygen

Abstract

H--NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H--NOX proteins comprise mutations that impart altered O.sub.2 or NO ligand-binding relative to the corresponding wild-type H--NOX domain, and are operative as physiologically compatible mammalian blood O.sub.2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H--NOX proteins for the treatment of any condition for which delivery of O.sub.2 is beneficial.

Inventors:

Cary, Stephen P. L.; Boon, Elizabeth M.; Weinert, Emily; Winger, Jonathan A.; Marletta, Michael A.

Issue Date:

2019-02-12

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1502841

Patent Number(s):

10202428

Application Number:

15/292,012

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K38/00 - Medicinal preparations containing peptides

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P13/12 - of the kidneys
A61P17/02 - for treating wounds, ulcers, burns, scars, keloids, or the like
A61P25/00 - Drugs for disorders of the nervous system
A61P43/00 - Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P7/00 - Drugs for disorders of the blood or the extracellular fluid
A61P7/04 - Antihaemorrhagics
A61P7/06 - Antianaemics
A61P7/08 - Plasma substitutes
A61P9/00 - Drugs for disorders of the cardiovascular system
A61P9/04 - Inotropic agents, i.e. stimulants of cardiac contraction
A61P9/10 - for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P9/12 - Antihypertensives

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/195 - from bacteria
C07K14/33 - from Clostridium
C07K14/435 - from animals
C07K14/43545 - {from Caenorhabditis}
C07K14/43563 - {from insects}
C07K14/43581 - {from Drosophila}
C07K14/47 - from mammals

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

Y02A50/30 - Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Y10T436/102499 - Blood gas standard or control

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DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 2016 Oct 12

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES