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Title: Bioreactors including enzyme-embedded multicomponent polymers

Abstract

According to one general embodiment, a membrane, includes a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network. According to another embodiment, a bioreactor includes a lattice of three dimensional structures, each structure including a membrane having: a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1502840
Patent Number(s):
10202567
Application Number:
15/003,257
Assignee:
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B33 - ADDITIVE MANUFACTURING TECHNOLOGY B33Y - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Jan 21
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Stolaroff, Joshuah K., Aines, Roger, Baker, Sarah, Blanchette, Craig D., Maiti, Amitesh, Vericella, John, and Oakdale, James S. Bioreactors including enzyme-embedded multicomponent polymers. United States: N. p., 2019. Web.
Stolaroff, Joshuah K., Aines, Roger, Baker, Sarah, Blanchette, Craig D., Maiti, Amitesh, Vericella, John, & Oakdale, James S. Bioreactors including enzyme-embedded multicomponent polymers. United States.
Stolaroff, Joshuah K., Aines, Roger, Baker, Sarah, Blanchette, Craig D., Maiti, Amitesh, Vericella, John, and Oakdale, James S. Tue . "Bioreactors including enzyme-embedded multicomponent polymers". United States. https://www.osti.gov/servlets/purl/1502840.
@article{osti_1502840,
title = {Bioreactors including enzyme-embedded multicomponent polymers},
author = {Stolaroff, Joshuah K. and Aines, Roger and Baker, Sarah and Blanchette, Craig D. and Maiti, Amitesh and Vericella, John and Oakdale, James S.},
abstractNote = {According to one general embodiment, a membrane, includes a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network. According to another embodiment, a bioreactor includes a lattice of three dimensional structures, each structure including a membrane having: a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {2}
}

Patent:

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Works referenced in this record:

Isolation, Characterization, and Stability of Discretely-Sized Nanolipoprotein Particles Assembled with Apolipophorin-III
journal, July 2010


Pure and mixed gas CH4 and n-C4H10 permeability and diffusivity in poly(dimethylsiloxane)
journal, December 2007


Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes
journal, May 2013


Encapsulated liquid sorbents for carbon dioxide capture
journal, February 2015


Progress in enzymatic membrane reactors – a review
journal, October 2004


Synthesis and Characterization of Amphiphilic Lipopolymers for Micellar Drug Delivery
journal, October 2010


Particle-loaded hollow-fiber membrane adsorbers for lysozyme separation
journal, September 2008


The Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath) Is a Novel Copper-containing Three-subunit Enzyme : ISOLATION AND CHARACTERIZATION
journal, April 1998


The solubility of hydrocarbon gases in lipid bilayers
journal, November 1977


Conductivity of carbon nanotube polymer composites
journal, January 2007


SnO 2 Nanoribbons as NO 2 Sensors:  Insights from First Principles Calculations
journal, August 2003


Engineering the third wave of biocatalysis
journal, May 2012


Aerobic and anaerobic methane oxidation in terrestrial mud volcanoes in the Northern Apennines
journal, July 2012


Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
journal, July 2003


Imaging cerebroside-rich domains for phase and shape characterization in binary and ternary mixtures
journal, July 2010


Atomistic modeling of CO2 capture in primary and tertiary amines – Heat of absorption and density changes
journal, June 2011


Electrically Addressable Biomolecular Functionalization of Carbon Nanotube and Carbon Nanofiber Electrodes
journal, September 2004


Amphiphilic polymer conetworks as chiral separation membranes
journal, April 2011


Maleimide Cross-Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross-Linking for Cell Encapsulation and In Situ Delivery
journal, December 2011


Evidence for Oxygen Binding at the Active Site of Particulate Methane Monooxygenase
journal, April 2012


Conjugation to Nickel-Chelating Nanolipoprotein Particles Increases the Potency and Efficacy of Subunit Vaccines to Prevent West Nile Encephalitis
journal, June 2010


Direct Catalytic Conversion of Methane to Methanol in an Aqueous Medium by using Copper-Promoted Fe-ZSM-5
journal, April 2012


Review of Methane Mitigation Technologies with Application to Rapid Release of Methane from the Arctic
journal, May 2012


Photoinitiated Polymerization: Advances, Challenges, and Opportunities
journal, August 2010


Complete Oxidation of Methanol in Biobattery Devices Using a Hydrogel Created from Three Modified Dehydrogenases
journal, December 2012


Blood Clot Initiation by Mesocellular Foams: Dependence on Nanopore Size and Enzyme Immobilization
journal, December 2008


Synthesis of glycine-containing complexes in impacts of comets on early Earth
journal, September 2010


New materials for methane capture from dilute and medium-concentration sources
journal, April 2013


Ultralight, ultrastiff mechanical metamaterials
journal, June 2014


Biocatalytic plastics as active and stable materials for biotransformations
journal, August 1997


Amphiphilic Network as Nanoreactor for Enzymes in Organic Solvents
journal, January 2005


Gas and Vapor Solubility in Cross-Linked Poly(ethylene Glycol Diacrylate)
journal, October 2005


Characterization and Purification of Polydisperse Reconstituted Lipoproteins and Nanolipoprotein Particles
journal, July 2009


Carbon Dioxide Capture from Atmospheric Air Using Sodium Hydroxide Spray
journal, April 2008


Effect of Age and Cytoskeletal Elements on the Indentation-Dependent Mechanical Properties of Chondrocytes
journal, April 2013


Performance of Chloroperoxidase Stabilization in Mesoporous Sol-Gel Glass Using <I>In Situ</I> Glucose Oxidase Peroxide Generation
journal, January 2004


Reaction mechanisms in the radiolysis of peptides, polypeptides, and proteins
journal, April 1987


Enhanced Cellulose Degradation Using Cellulase-Nanosphere Complexes
journal, August 2012


Rethinking biological activation of methane and conversion to liquid fuels
journal, April 2014


Enzyme Immobilization: The Quest for Optimum Performance
journal, June 2007


Efficient immobilization of epoxide hydrolase onto silica gel and use in the enantioselective hydrolysis of racemic para-nitrostyrene oxide
journal, March 2005


Gas permeation through water-swollen hydrogel membranes
journal, March 2008


Kinetic Analysis of His-Tagged Protein Binding to Nickel-Chelating Nanolipoprotein Particles
journal, July 2010


Modeling and generating parallel flexure elements
journal, July 2014


Catalysis Research of Relevance to Carbon Management:  Progress, Challenges, and Opportunities
journal, April 2001


Detection of bio-organism simulants using random binding on a defect-free photonic crystal
journal, September 2010


Enrichment, Isolation and Some Properties of Methane-utilizing Bacteria
journal, May 1970


Painting and Printing Living Bacteria: Engineering Nanoporous Biocatalytic Coatings to Preserve Microbial Viability and Intensify Reactivity
journal, February 2007


Solvent screening for a hard-to-dissolve molecular crystal
journal, January 2008


Organ printing: computer-aided jet-based 3D tissue engineering
journal, April 2003


Natural strategies for the spatial optimization of metabolism in synthetic biology
journal, May 2012


Immobilisation behaviour of biomolecules in mesoporous silica materials
journal, September 2005


Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens
journal, January 2013


Effect of Adsorbates on Field Emission from Carbon Nanotubes
journal, September 2001


Three-Dimensional Printing of Elastomeric, Cellular Architectures with Negative Stiffness
journal, May 2014


Covalent Functionalization for Biomolecular Recognition on Vertically Aligned Carbon Nanofibers
journal, October 2005


Gas Permeation and Diffusion in Cross-Linked Poly(ethylene glycol diacrylate)
journal, May 2006


Envisioning the Bioconversion of Methane to Liquid Fuels
journal, February 2014


Controlling Bioprocesses with Inorganic Surfaces:  Layered Clay Hemostatic Agents
journal, September 2007


The Effect of Cross-Linking on Gas Permeability in Cross-Linked Poly(Ethylene Glycol Diacrylate)
journal, October 2005


Potential of Different Enzyme Immobilization Strategies to Improve Enzyme Performance
journal, November 2011


High-Throughput Printing via Microvascular Multinozzle Arrays
journal, October 2012


Industrial biocatalysis today and tomorrow
journal, January 2001


Oxidation of methane by a biological dicopper centre
journal, April 2010


Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization
journal, May 2001


Perspective of Recent Progress in Immobilization of Enzymes
journal, July 2011


High-Density Reconstitution of Functional Water Channels into Vesicular and Planar Block Copolymer Membranes
journal, November 2012


Functionalized Vertically Aligned Carbon Nanofibers as Scaffolds for Immobilization and Electrochemical Detection of Redox-Active Proteins
journal, September 2006


Preparation of water-swollen hydrogel membranes for gas separation
journal, January 2001


Effects of Zinc on Particulate Methane Monooxygenase Activity and Structure
journal, June 2014


Structural Characteristics and Swelling Behavior of Poly(ethylene glycol) Diacrylate Hydrogels
journal, January 1996


Enabling Industrial Biocatalytic Processes by Application of Silicone-Coated Enzyme Preparations
journal, September 2011


Printable enzyme-embedded materials for methane to methanol conversion
journal, June 2016


Design issues in a mandatory greenhouse gas emissions registry for the United States
journal, September 2009


Substrate channeling and enzyme complexes for biotechnological applications
journal, November 2011


Enzymatic Oxidation of Methane
journal, March 2015


Hydrogels as Extracellular Matrices for Skeletal Tissue Engineering: State-of-the-Art and Novel Application in Organ Printing
journal, August 2007


Designing biological compartmentalization
journal, December 2012