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Title: Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging

Abstract

Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1502820
Patent Number(s):
10,203,307
Application Number:
14/729,999
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Jun 03
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Wang, Daojing, Mao, Pan, Gomez-Sjoberg, Rafael, Wang, Hung-Tu, and Yang, Peidong. Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging. United States: N. p., 2019. Web.
Wang, Daojing, Mao, Pan, Gomez-Sjoberg, Rafael, Wang, Hung-Tu, & Yang, Peidong. Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging. United States.
Wang, Daojing, Mao, Pan, Gomez-Sjoberg, Rafael, Wang, Hung-Tu, and Yang, Peidong. Tue . "Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging". United States. https://www.osti.gov/servlets/purl/1502820.
@article{osti_1502820,
title = {Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging},
author = {Wang, Daojing and Mao, Pan and Gomez-Sjoberg, Rafael and Wang, Hung-Tu and Yang, Peidong},
abstractNote = {Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {2}
}

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Works referenced in this record:

Multinozzle Emitter Array Chips for Small-Volume Proteomics
journal, December 2012

  • Mao, Pan; Gomez-Sjoberg, Rafael; Wang, Daojing
  • Analytical Chemistry, Vol. 85, Issue 2
  • DOI: 10.1021/ac3032965

Multinozzle Emitter Arrays for Nanoelectrospray Mass Spectrometry
journal, August 2011

  • Mao, Pan; Wang, Hung-Ta; Yang, Peidong
  • Analytical Chemistry, Vol. 83, Issue 15, p. 6082-6089
  • DOI: 10.1021/ac2011813

Microfabricated Monolithic Multinozzle Emitters for Nanoelectrospray Mass Spectrometry
journal, May 2007

  • Kim, Woong; Guo, Mingquan; Yang, Peidong
  • Analytical Chemistry, Vol. 79, Issue 10, p. 3703-3707
  • DOI: 10.1021/ac070010j