DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging

Abstract

Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1502820
Patent Number(s):
10203307
Application Number:
14/729,999
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Jun 03
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Wang, Daojing, Mao, Pan, Gomez-Sjoberg, Rafael, Wang, Hung-Tu, and Yang, Peidong. Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging. United States: N. p., 2019. Web.
Wang, Daojing, Mao, Pan, Gomez-Sjoberg, Rafael, Wang, Hung-Tu, & Yang, Peidong. Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging. United States.
Wang, Daojing, Mao, Pan, Gomez-Sjoberg, Rafael, Wang, Hung-Tu, and Yang, Peidong. Tue . "Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging". United States. https://www.osti.gov/servlets/purl/1502820.
@article{osti_1502820,
title = {Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging},
author = {Wang, Daojing and Mao, Pan and Gomez-Sjoberg, Rafael and Wang, Hung-Tu and Yang, Peidong},
abstractNote = {Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {2}
}

Works referenced in this record:

PAEK-based microfluidic device with integrated electrospray emitter
patent, August 2008


Microdroplet ionisation mass spectrometry
patent, November 2016


Microfluidic devices and methods
patent, March 2006


Monolithic multinozzle emitters for nanoelectrospray mass spectrometry
patent, September 2011


Fully integrated miniaturized planar liquid sample handling and analysis device
patent, November 1996


Fully integrated miniaturized planar liquid sample handling and analysis device
patent, October 1999


Microfluidic devices with porous regions
patent, June 2004


Electrospray emitter
patent-application, July 2003


Electrospray interface
patent-application, April 2004


Multinozzle Emitter Array Chips for Small-Volume Proteomics
journal, December 2012


Multi-layer microfluidic devices
patent, January 2001


Micromachined flow cell with freestanding fluidic tube
patent, September 2017


Multinozzle Emitter Arrays for Nanoelectrospray Mass Spectrometry
journal, August 2011


Flow-switching microdevice
patent, January 2005


Paek-based microfluidic device with integrated electrospray emitter
patent-application, August 2004


Microchip and particle analyzing apparatus
patent, October 2016


Particle packing of microdevice
patent, July 2006


System and method for performing multiple parallel chromatographic separations
patent, August 2005


Unitary microcapiliary and waveguide structure and method of fabrication
patent, August 2002


Microfluidic devices and methods of fabrication
patent, February 2014


Scanned source oriented nanofiber formation
patent, April 2013


Miniaturized planar columns in novel support media for liquid phase analysis
patent, March 1996


Microfluidic device for sample analysis
patent, October 2010


Microfabricated Monolithic Multinozzle Emitters for Nanoelectrospray Mass Spectrometry
journal, May 2007


Flow control in multi-stream microfluidic devices
patent, December 2002