Title: C-halogen bond formation

Abstract

Methods of halogenating a carbon containing compound having an sp3 C--H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C--H fluorination of a carbon containing compound having an sp3 C--H bond are provided. The halogenated products of the methods are provided.

Inventors:

Groves, John T.; Liu, Wei

Issue Date:

2019-02-05

Research Org.:

Princeton Univ., NJ (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1502471

Patent Number(s):

10196341

Application Number:

14/239,706

Assignee:

The Trustees Of Princeton University (Princeton, NJ)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C07B39/00 - Halogenation

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C17/06 - combined with replacement of hydrogen atoms by halogens
C07C17/35 - by reactions not affecting the number of carbon or of halogen atoms in the reaction
C07C19/01 - containing chlorine
C07C22/00 - Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
C07C22/04 - containing six-membered aromatic rings
C07C22/08 - containing fluorine
C07C231/12 - by reactions not involving the formation of carboxamide groups
C07C233/14 - with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
C07C67/307 - by introduction of halogen
C07C69/608 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

C07D307/83 - Oxygen atoms
C07D401/14 - containing three or more hetero rings

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic System
C07F5/025 - {Boronic and borinic acid compounds}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07J - STEROIDS

C07J1/0011 - {substituted in position 17 by a keto group}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Y02P20/582 - of unreacted starting or intermediate materials

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DOE Contract Number:  

SC0001298

Resource Type:

Patent

Resource Relation:

Patent File Date: 2012 Aug 20

Country of Publication:

United States

Language:

English