Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same

Valdez, Carlos; Lau, Edmond Y.; Mayer, Brian P.

Title: Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same

Abstract

A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.

Inventors:: Valdez, Carlos; Lau, Edmond Y.; Mayer, Brian P.

Issue Date:: 2019-01-29

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1500054

Patent Number(s):: 10189864

Application Number:: 15/048,921

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A62 - LIFE-SAVING A62D - CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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A - HUMAN NECESSITIES A62 - LIFE-SAVING A62D - CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS
A62D2101/02 - Chemical warfare substances, e.g. cholinesterase inhibitors
A62D2101/04 - Pesticides, e.g. insecticides, herbicides, fungicides or nematocides
A62D2101/26 - containing nitrogen or phosphorus
A62D2101/45 - containing nitrogen or phosphorus
A62D3/38 - by oxidation

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D401/14 - containing three or more hetero rings

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F1/08 - Copper compounds
C07F15/025 - {without a metal-carbon linkage}
C07F15/045 - {without a metal-carbon linkage}
C07F15/065 - {without a metal-carbon linkage}
C07F3/06 - Zinc compounds

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DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Resource Relation:: Patent File Date: 2016 Feb 19

Country of Publication:: United States

Language:: English

Citation Formats


                    Valdez, Carlos, Lau, Edmond Y., and Mayer, Brian P.. Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same.  United States: N. p., 2019. 
        Web.

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                    Valdez, Carlos, Lau, Edmond Y., & Mayer, Brian P.. Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same.  United States.

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                    Valdez, Carlos, Lau, Edmond Y., and Mayer, Brian P.. Tue .  
        "Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same".  United States.  https://www.osti.gov/servlets/purl/1500054.

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@article{osti_1500054,

  title        = {Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same},

  author       = {Valdez, Carlos and Lau, Edmond Y. and Mayer, Brian P.},

  abstractNote = {A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {1}

}

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Works referenced in this record:

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Similar Records

Title: Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same

Abstract

Citation Formats

Coordination chemistry of heterocycle-functionalized diazamesocycles: tuning the productive NiII complexes through altering the pendants of ligands journal, March 2005

Bifunctional heterocyclic compounds and methods of making and using same patent, August 2006

Substituted 1,4-diazapine caprolactams useful for treatment of HIV disease patent, September 1997

Method for neutralizing organophosphorus agricultural chemicals patent, August 2001

Synthesis, crystal structure and properties of the CuII complex of a tetradentate imidazole-functionalized diazamesocyclic ligand, 1,4-bis(N-1-methylimidazol-2-yl-methyl)-1,4-diazacycloheptane journal, October 2002

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2) journal, December 2014

Copper-catalyzed regioselective hydroboration of terminal alkynes in aqueous medium journal, February 2016

Highly Sensitive Fluorescent Probes for Zinc Ion Based on Triazolyl-Containing Tetradentate Coordination Motifs journal, October 2007

Two multidentate ligands utilizing triazolyl, pyridinyl and phenolate groups as donors for constructing dinuclear copper(II) and iron(III) complexes: Syntheses, structures, and electrochemistry journal, November 2014

Cyclic diamine compound with 5-membered ring groups patent, October 2002

A Click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates journal, January 2011

Coordination chemistry of heterocycle-functionalized diazamesocycles: tuning the productive Ni^II complexes through altering the pendants of ligands
journal, March 2005

Bifunctional heterocyclic compounds and methods of making and using same
patent, August 2006

Substituted 1,4-diazapine caprolactams useful for treatment of HIV disease
patent, September 1997

Method for neutralizing organophosphorus agricultural chemicals
patent, August 2001

Synthesis, crystal structure and properties of the CuII complex of a tetradentate imidazole-functionalized diazamesocyclic ligand, 1,4-bis(N-1-methylimidazol-2-yl-methyl)-1,4-diazacycloheptane
journal, October 2002

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)
journal, December 2014

Copper-catalyzed regioselective hydroboration of terminal alkynes in aqueous medium
journal, February 2016

Highly Sensitive Fluorescent Probes for Zinc Ion Based on Triazolyl-Containing Tetradentate Coordination Motifs
journal, October 2007

Two multidentate ligands utilizing triazolyl, pyridinyl and phenolate groups as donors for constructing dinuclear copper(II) and iron(III) complexes: Syntheses, structures, and electrochemistry
journal, November 2014

Cyclic diamine compound with 5-membered ring groups
patent, October 2002

A Click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates
journal, January 2011