Transgenic cells with increased plastoquinone levels and methods of use
Abstract
Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the disclosed transgenic cells have increased plastoquinone levels. Also disclosed are methods of increasing cell growth rates or production of biomass by cultivating transgenic cells expressing a heterologous nucleic acid encoding a PDH protein, a heterologous nucleic acid encoding an HST protein, a heterologous nucleic acid encoding a DXS protein, or a combination of two or more thereof under conditions sufficient to produce cell growth or biomass.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1496861
- Patent Number(s):
- 10106809
- Application Number:
- 15/389,061
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2016 Dec 22
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 09 BIOMASS FUELS
Citation Formats
Sayre, Richard T., Subramanian, Sowmya, and Cahoon, Edgar. Transgenic cells with increased plastoquinone levels and methods of use. United States: N. p., 2018.
Web.
Sayre, Richard T., Subramanian, Sowmya, & Cahoon, Edgar. Transgenic cells with increased plastoquinone levels and methods of use. United States.
Sayre, Richard T., Subramanian, Sowmya, and Cahoon, Edgar. Tue .
"Transgenic cells with increased plastoquinone levels and methods of use". United States. https://www.osti.gov/servlets/purl/1496861.
@article{osti_1496861,
title = {Transgenic cells with increased plastoquinone levels and methods of use},
author = {Sayre, Richard T. and Subramanian, Sowmya and Cahoon, Edgar},
abstractNote = {Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the disclosed transgenic cells have increased plastoquinone levels. Also disclosed are methods of increasing cell growth rates or production of biomass by cultivating transgenic cells expressing a heterologous nucleic acid encoding a PDH protein, a heterologous nucleic acid encoding an HST protein, a heterologous nucleic acid encoding a DXS protein, or a combination of two or more thereof under conditions sufficient to produce cell growth or biomass.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {10}
}
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Works referenced in this record:
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana
journal, September 2002
- Rippert, Pascal; Matringe, Michel
- European Journal of Biochemistry, Vol. 269, Issue 19, p. 4753-4761
Increasing anthraquinone production by overexpression of 1-deoxy-d-xylulose-5-phosphate synthase in transgenic cell suspension cultures of Morinda citrifolia
journal, March 2010
- Quevedo, Carla; Perassolo, María; Alechine, Eugenia
- Biotechnology Letters, Vol. 32, Issue 7, p. 997-1003
Constitutive overexpression of barley 4-hydroxyphenylpyruvate dioxygenase in tobacco results in elevation of the vitamin E content in seeds but not in leaves
journal, March 2003
- Falk, Jon; Andersen, Gaby; Kernebeck, Birgit
- FEBS Letters, Vol. 540, Issue 1-3, p. 35-40
Optimization of photosynthetic light energy utilization by microalgae
journal, October 2012
- Perrine, Zoee; Negi, Sangeeta; Sayre, Richard T.
- Algal Research, Vol. 1, Issue 2, p. 134-142
Engineering Plant Shikimate Pathway for Production of Tocotrienol and Improving Herbicide Resistance
journal, December 2003
- Rippert, Pascal; Scimemi, Claire; Dubald, Manuel
- Plant Physiology, Vol. 134, Issue 1
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis
journal, September 2006
- Sadre, Radin; Gruber, Jens; Frentzen, Margrit
- FEBS Letters, Vol. 580, Issue 22, p. 5357-5362
The pds2 mutation is a lesion in the Arabidopsis homogentisate solanesyltransferase gene involved in plastoquinone biosynthesis
journal, June 2007
- Tian, Li; DellaPenna, Dean; Dixon, Richard A.
- Planta, Vol. 226, Issue 4