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Title: Gene modification in clostridium for increased alcohol production

Abstract

The present disclosure is directed to genetically engineered bacteria strains with enhanced biofuel-producing capabilities from cellulosic substrates. The bacteria strains of the present disclosure comprise an inactivated Type I glutamine synthetase gene. The present disclosure is also directed to methods of producing biofuels from cellulosic biomass using the genetically engineered bacteria strains.

Inventors:
;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1496801
Patent Number(s):
10,179,907
Application Number:
15/643,580
Assignee:
UT-BATTELLE, LLC (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-000R22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Jul 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rydzak, Thomas, and Guss, Adam M. Gene modification in clostridium for increased alcohol production. United States: N. p., 2019. Web.
Rydzak, Thomas, & Guss, Adam M. Gene modification in clostridium for increased alcohol production. United States.
Rydzak, Thomas, and Guss, Adam M. Tue . "Gene modification in clostridium for increased alcohol production". United States. https://www.osti.gov/servlets/purl/1496801.
@article{osti_1496801,
title = {Gene modification in clostridium for increased alcohol production},
author = {Rydzak, Thomas and Guss, Adam M.},
abstractNote = {The present disclosure is directed to genetically engineered bacteria strains with enhanced biofuel-producing capabilities from cellulosic substrates. The bacteria strains of the present disclosure comprise an inactivated Type I glutamine synthetase gene. The present disclosure is also directed to methods of producing biofuels from cellulosic biomass using the genetically engineered bacteria strains.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {1}
}

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Works referenced in this record:

High Ethanol Titers from Cellulose by Using Metabolically Engineered Thermophilic, Anaerobic Microbes
journal, September 2011

  • Argyros, D. Aaron; Tripathi, Shital A.; Barrett, Trisha F.
  • Applied and Environmental Microbiology, Vol. 77, Issue 23, p. 8288-8294
  • DOI: 10.1128/AEM.00646-11

Development of pyrF-Based Genetic System for Targeted Gene Deletion in Clostridium thermocellum and Creation of a pta Mutant
journal, August 2010

  • Tripathi, S. A.; Olson, D. G.; Argyros, D. A.
  • Applied and Environmental Microbiology, Vol. 76, Issue 19, p. 6591-6599
  • DOI: 10.1128/AEM.01484-10

Redirecting carbon flux through exogenous pyruvate kinase to achieve high ethanol yields in Clostridium thermocellum
journal, January 2013