skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Gene modification in clostridium for increased alcohol production

Abstract

The present disclosure is directed to genetically engineered bacteria strains with enhanced biofuel-producing capabilities from cellulosic substrates. The bacteria strains of the present disclosure comprise an inactivated Type I glutamine synthetase gene. The present disclosure is also directed to methods of producing biofuels from cellulosic biomass using the genetically engineered bacteria strains.

Inventors:
;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1496801
Patent Number(s):
10179907
Application Number:
15/643,580
Assignee:
UT-BATTELLE, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
DOE Contract Number:  
AC05-000R22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Jul 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rydzak, Thomas, and Guss, Adam M. Gene modification in clostridium for increased alcohol production. United States: N. p., 2019. Web.
Rydzak, Thomas, & Guss, Adam M. Gene modification in clostridium for increased alcohol production. United States.
Rydzak, Thomas, and Guss, Adam M. Tue . "Gene modification in clostridium for increased alcohol production". United States. https://www.osti.gov/servlets/purl/1496801.
@article{osti_1496801,
title = {Gene modification in clostridium for increased alcohol production},
author = {Rydzak, Thomas and Guss, Adam M.},
abstractNote = {The present disclosure is directed to genetically engineered bacteria strains with enhanced biofuel-producing capabilities from cellulosic substrates. The bacteria strains of the present disclosure comprise an inactivated Type I glutamine synthetase gene. The present disclosure is also directed to methods of producing biofuels from cellulosic biomass using the genetically engineered bacteria strains.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

High Ethanol Titers from Cellulose by Using Metabolically Engineered Thermophilic, Anaerobic Microbes
journal, September 2011


Elimination of formate production in Clostridium thermocellum
journal, July 2015


Development of pyrF-Based Genetic System for Targeted Gene Deletion in Clostridium thermocellum and Creation of a pta Mutant
journal, August 2010


Characterization of Clostridium thermocellum strains with disrupted fermentation end-product pathways
journal, May 2013


Clostridium thermocellum transcriptomic profiles after exposure to furfural or heat stress
journal, January 2013


Closing the carbon balance for fermentation by Clostridium thermocellum (ATCC 27405)
journal, January 2012


Redirecting carbon flux through exogenous pyruvate kinase to achieve high ethanol yields in Clostridium thermocellum
journal, January 2013


Elimination of hydrogenase active site assembly blocks H2 production and increases ethanol yield in Clostridium thermocellum
journal, January 2015


Dcm methylation is detrimental to plasmid transformation in Clostridium thermocellum
journal, January 2012


The exometabolome of Clostridium thermocellum reveals overflow metabolism at high cellulose loading
journal, October 2014