Mosaic vaccines for serotype a foot-and-mouth disease virus
Abstract
Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1496592
- Patent Number(s):
- 10172933
- Application Number:
- 15/785,875
- Assignee:
- The United States of America, as represented by The Secretary of Agriculture (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2017 Oct 17
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Rieder, Aida E., Fischer, William M., and Rai, Devendra K. Mosaic vaccines for serotype a foot-and-mouth disease virus. United States: N. p., 2019.
Web.
Rieder, Aida E., Fischer, William M., & Rai, Devendra K. Mosaic vaccines for serotype a foot-and-mouth disease virus. United States.
Rieder, Aida E., Fischer, William M., and Rai, Devendra K. Tue .
"Mosaic vaccines for serotype a foot-and-mouth disease virus". United States. https://www.osti.gov/servlets/purl/1496592.
@article{osti_1496592,
title = {Mosaic vaccines for serotype a foot-and-mouth disease virus},
author = {Rieder, Aida E. and Fischer, William M. and Rai, Devendra K.},
abstractNote = {Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {1}
}
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Works referenced in this record:
Foot and mouth disease virus with increased stability and its use as vaccine
patent, September 2015
- Fowler, Veronica; Knowles, Nick; Barnett, Paul
- US Patent Document 9,145,548
Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle
journal, July 2016
- Xiao, Yan; Chen, Hong-Ying; Wang, Yuzhou
- BMC Biotechnology, Vol. 16, Issue 1