skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mosaic vaccines for serotype a foot-and-mouth disease virus

Abstract

Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.

Inventors:
; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1496592
Patent Number(s):
10,172,933
Application Number:
15/785,875
Assignee:
The United States of America, as represented by The Secretary of Agriculture (Washington, DC) LANL
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Oct 17
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Rieder, Aida E., Fischer, William M., and Rai, Devendra K. Mosaic vaccines for serotype a foot-and-mouth disease virus. United States: N. p., 2019. Web.
Rieder, Aida E., Fischer, William M., & Rai, Devendra K. Mosaic vaccines for serotype a foot-and-mouth disease virus. United States.
Rieder, Aida E., Fischer, William M., and Rai, Devendra K. Tue . "Mosaic vaccines for serotype a foot-and-mouth disease virus". United States. https://www.osti.gov/servlets/purl/1496592.
@article{osti_1496592,
title = {Mosaic vaccines for serotype a foot-and-mouth disease virus},
author = {Rieder, Aida E. and Fischer, William M. and Rai, Devendra K.},
abstractNote = {Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {1}
}

Patent:

Save / Share: