Microneedle arrays for biosensing and drug delivery

Wang, Joseph; Windmiller, Joshua Ray; Narayan, Roger; Miller, Phillip; Polsky, Ronen; Edwards, Thayne L.

Title: Microneedle arrays for biosensing and drug delivery

Abstract

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Inventors:: Wang, Joseph; Windmiller, Joshua Ray; Narayan, Roger; Miller, Phillip; Polsky, Ronen; Edwards, Thayne L.

Issue Date:: 2018-11-27

Research Org.:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1495373

Patent Number(s):: 10136846

Application Number:: 15/687,145

Assignee:: The Regents of the University of California (Oakland, CA); North Carolina State University (Raleigh, NC); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B10/0045 - {Devices for taking samples of body liquids
A61B2010/008 - {Interstitial fluid}
A61B2562/028 - Microscale sensors, e.g. electromechanical sensors [MEMS]
A61B2562/046 - in a matrix array
A61B5/14514 - {using means for aiding extraction of interstitial fluid, e.g. microneedles or suction}
A61B5/14532 - {for measuring glucose, e.g. by tissue impedance measurement}
A61B5/14546 - {for measuring analytes not otherwise provided for, e.g. ions, cytochromes}
A61B5/1473 - invasive, e.g. introduced into the body by a catheter {
A61B5/14865 - {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors}
A61B5/150984 - {Microneedles or microblades}
A61B5/157 - {Devices} characterised by integrated means for measuring characteristics of blood
A61B5/4845 - {Toxicology, e.g. by detection of alcohol, drug or toxic products
A61B5/6833 - {Adhesive patches}
A61B5/685 - {Microneedles}
A61B5/7282 - {Event detection, e.g. detecting unique waveforms indicative of a medical condition

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A61M2005/1726 - {the body parameters being measured at, or proximate to, the infusion site}
A61M2037/0023 - {Drug applicators using microneedles}
A61M2037/003 - {having a lumen}
A61M5/158 - Needles {for infusions
A61M5/1723 - {using feedback of body parameters, e.g. blood-sugar, pressure

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/48785 - {Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply}

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2017 Aug 25

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Phillip, Polsky, Ronen, and Edwards, Thayne L. Microneedle arrays for biosensing and drug delivery.  United States: N. p., 2018. 
        Web.

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                    Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Phillip, Polsky, Ronen, & Edwards, Thayne L. Microneedle arrays for biosensing and drug delivery.  United States.

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                    Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Phillip, Polsky, Ronen, and Edwards, Thayne L. Tue .  
        "Microneedle arrays for biosensing and drug delivery".  United States.  https://www.osti.gov/servlets/purl/1495373.

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@article{osti_1495373,

  title        = {Microneedle arrays for biosensing and drug delivery},

  author       = {Wang, Joseph and Windmiller, Joshua Ray and Narayan, Roger and Miller, Phillip and Polsky, Ronen and Edwards, Thayne L.},

  abstractNote = {Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2018},

  month        = {11}

}

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