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Title: Microneedle arrays for biosensing and drug delivery

Abstract

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1495373
Patent Number(s):
10,136,846
Application Number:
15/687,145
Assignee:
The Regents of the University of California (Oakland, CA); North Carolina State University (Raleigh, NC); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM) SNL
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Aug 25
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Phillip, Polsky, Ronen, and Edwards, Thayne L. Microneedle arrays for biosensing and drug delivery. United States: N. p., 2018. Web.
Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Phillip, Polsky, Ronen, & Edwards, Thayne L. Microneedle arrays for biosensing and drug delivery. United States.
Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Phillip, Polsky, Ronen, and Edwards, Thayne L. Tue . "Microneedle arrays for biosensing and drug delivery". United States. https://www.osti.gov/servlets/purl/1495373.
@article{osti_1495373,
title = {Microneedle arrays for biosensing and drug delivery},
author = {Wang, Joseph and Windmiller, Joshua Ray and Narayan, Roger and Miller, Phillip and Polsky, Ronen and Edwards, Thayne L.},
abstractNote = {Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {11}
}

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Works referenced in this record:

Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process
journal, March 2009

  • Gittard, Shaun D.; Ovsianikov, Aleksandr; Monteiro-Riviere, Nancy A.
  • Journal of Diabetes Science and Technology, Vol. 3, Issue 2, p. 304-311
  • DOI: 10.1177/193229680900300211

Electrically Actuatable Smart Nanoporous Membrane for Pulsatile Drug Release
journal, March 2011

  • Jeon, Gumhye; Yang, Seung Yun; Byun, Jinseok
  • Nano Letters, Vol. 11, Issue 3, p. 1284-1288
  • DOI: 10.1021/nl104329y

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
journal, March 2011

  • Miller, Philip R.; Gittard, Shaun D.; Edwards, Thayne L.
  • Biomicrofluidics, Vol. 5, Issue 1, Article No. 013415
  • DOI: 10.1063/1.3569945

Bicomponent Microneedle Array Biosensor for Minimally-Invasive Glutamate Monitoring
journal, September 2011

  • Windmiller, Joshua Ray; Vald�s-Ram�rez, Gabriela; Zhou, Nandi
  • Electroanalysis, Vol. 23, Issue 10, p. 2302-2309
  • DOI: 10.1002/elan.201100361