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Title: Bioactive compositions for high avidity cell capture

Abstract

A composition useful for cell capture, the composition comprising a solid substrate on which is affixed a patterned polymer, and a cell-targeting agent attached to said patterned polymer, wherein said cell-targeting agent is exposed. Also described is a method for the preparation of the cell capturing composition, as well as flow through devices in which the cell capturing composition is incorporated. Further described is a method of capturing cells by contacting the cell-capturing composition with a liquid or gaseous sample containing cells. The method for capturing cells may also be a method for testing for the presence of one or more classes or species of cells or cellular organisms in a liquid or gaseous sample.

Inventors:
; ; ; ; ; ; ;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1494583
Patent Number(s):
10,131,899
Application Number:
14/215,552
Assignee:
UT-BATTELLE, LLC (Oak Ridge, TN)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Mar 17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Hansen, Ryan Robert, Retterer, Scott T., Lokitz, Bradley Steward, Morrell-Falvey, Jennifer L., Salazar, Juan Pablo Hinestrosa, Messman, Jamie Michael, Kilbey, II, Sidney Michael, and Ankner, John Francis. Bioactive compositions for high avidity cell capture. United States: N. p., 2018. Web.
Hansen, Ryan Robert, Retterer, Scott T., Lokitz, Bradley Steward, Morrell-Falvey, Jennifer L., Salazar, Juan Pablo Hinestrosa, Messman, Jamie Michael, Kilbey, II, Sidney Michael, & Ankner, John Francis. Bioactive compositions for high avidity cell capture. United States.
Hansen, Ryan Robert, Retterer, Scott T., Lokitz, Bradley Steward, Morrell-Falvey, Jennifer L., Salazar, Juan Pablo Hinestrosa, Messman, Jamie Michael, Kilbey, II, Sidney Michael, and Ankner, John Francis. Tue . "Bioactive compositions for high avidity cell capture". United States. https://www.osti.gov/servlets/purl/1494583.
@article{osti_1494583,
title = {Bioactive compositions for high avidity cell capture},
author = {Hansen, Ryan Robert and Retterer, Scott T. and Lokitz, Bradley Steward and Morrell-Falvey, Jennifer L. and Salazar, Juan Pablo Hinestrosa and Messman, Jamie Michael and Kilbey, II, Sidney Michael and Ankner, John Francis},
abstractNote = {A composition useful for cell capture, the composition comprising a solid substrate on which is affixed a patterned polymer, and a cell-targeting agent attached to said patterned polymer, wherein said cell-targeting agent is exposed. Also described is a method for the preparation of the cell capturing composition, as well as flow through devices in which the cell capturing composition is incorporated. Further described is a method of capturing cells by contacting the cell-capturing composition with a liquid or gaseous sample containing cells. The method for capturing cells may also be a method for testing for the presence of one or more classes or species of cells or cellular organisms in a liquid or gaseous sample.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {11}
}

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Works referenced in this record:

Ring-opening metathesis polymerization-derived, lectin-functionalized monolithic supports for affinity separation of glycoproteins: Liquid Chromatography
journal, March 2013

  • Bandari, Rajendar; Kuballa, Jürgen; Buchmeiser, Michael R.
  • Journal of Separation Science, Vol. 36, Issue 7, p. 1169-1175
  • DOI: 10.1002/jssc.201201042

Well-Defined Azlactone-Functionalized (Co)polymers on a Solid Support:  Synthesis via Supported Living Radical Polymerization and Application as Nucleophile Scavengers
journal, July 2006

  • Fournier, David; Pascual, Sagrario; Montembault, Véronique
  • Journal of Combinatorial Chemistry, Vol. 8, Issue 4, p. 522-530
  • DOI: 10.1021/cc0600122

Hierarchically imprinted polymer substrates for enhanced attachment of Escherichia coli
journal, March 2010

  • Zhang, Fengxiang; Li, Hongzhe; Wang, Xin
  • Journal of Colloid and Interface Science, Vol. 343, Issue 1, p. 109-114
  • DOI: 10.1016/j.jcis.2009.11.038

Submicron Trenches Reduce the Pseudomonas fluorescens Colonization Rate on Solid Surfaces
journal, January 2009

  • Díaz, Carolina; Schilardi, Patricia L.; dos Santos Claro, Paula C.
  • ACS Applied Materials & Interfaces, Vol. 1, Issue 1, p. 136-143
  • DOI: 10.1021/am8000677

Nano/Microscale Order Affects the Early Stages of Biofilm Formation on Metal Surfaces
journal, October 2007

  • Díaz, C.; Schilardi, P. L.; Salvarezza, R. C.
  • Langmuir, Vol. 23, Issue 22, p. 11206-11210
  • DOI: 10.1021/la700650q

Microstructured Block Copolymer Surfaces for Control of Microbe Adhesion and Aggregation
journal, March 2014

  • Hansen, Ryan; Shubert, Katherine; Morrell-Falvey, Jennifer
  • Biosensors, Vol. 4, Issue 1
  • DOI: 10.3390/bios4010063

Lectin-Functionalized Poly(glycidyl methacrylate)- block -poly(vinyldimethyl azlactone) Surface Scaffolds for High Avidity Microbial Capture
journal, September 2013

  • Hansen, Ryan R.; Hinestrosa, Juan Pablo; Shubert, Katherine R.
  • Biomacromolecules, Vol. 14, Issue 10
  • DOI: 10.1021/bm4011358

Manipulating Interfaces through Surface Confinement of Poly(glycidyl methacrylate)- block -poly(vinyldimethylazlactone), a Dually Reactive Block Copolymer
journal, July 2012

  • Lokitz, Bradley S.; Wei, Jifeng; Hinestrosa, Juan Pablo
  • Macromolecules, Vol. 45, Issue 16
  • DOI: 10.1021/ma300991p

Protein Immobilization Strategies for Protein Biochips
journal, June 2007

  • Rusmini, Federica; Zhong, Zhiyuan; Feijen, Jan
  • Biomacromolecules, Vol. 8, Issue 6, p. 1775-1789
  • DOI: 10.1021/bm061197b

Nanopatterned Smart Polymer Surfaces for Controlled Attachment, Killing, and Release of Bacteria
journal, September 2013

  • Yu, Qian; Cho, Janghwan; Shivapooja, Phanindhar
  • ACS Applied Materials & Interfaces, Vol. 5, Issue 19, p. 9295-9304
  • DOI: 10.1021/am4022279

Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms
journal, May 2013

  • Zhao, Kun; Tseng, Boo Shan; Beckerman, Bernard
  • Nature, Vol. 497, Issue 7449
  • DOI: 10.1038/nature12155

Synthetic polymers for capture and detection of microorganisms
journal, January 2007

  • Pasparakis, George; Alexander, Cameron
  • The Analyst, Vol. 132, Issue 11
  • DOI: 10.1039/B705097F

Fabricating three-dimensional carbohydrate hydrogel microarray for lectin-mediated bacterium capturing
journal, August 2014


Tailored Silicon Nanopost Arrays for Resonant Nanophotonic Ion Production
journal, February 2010

  • Walker, Bennett N.; Stolee, Jessica A.; Pickel, Deanna L.
  • The Journal of Physical Chemistry C, Vol. 114, Issue 11
  • DOI: 10.1021/jp9110103