skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Bioactive compositions for high avidity cell capture

Abstract

A composition useful for cell capture, the composition comprising a solid substrate on which is affixed a patterned polymer, and a cell-targeting agent attached to said patterned polymer, wherein said cell-targeting agent is exposed. Also described is a method for the preparation of the cell capturing composition, as well as flow through devices in which the cell capturing composition is incorporated. Further described is a method of capturing cells by contacting the cell-capturing composition with a liquid or gaseous sample containing cells. The method for capturing cells may also be a method for testing for the presence of one or more classes or species of cells or cellular organisms in a liquid or gaseous sample.

Inventors:
; ; ; ; ; ; ;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1494583
Patent Number(s):
10131899
Application Number:
14/215,552
Assignee:
UT-BATTELLE, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Mar 17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Hansen, Ryan Robert, Retterer, Scott T., Lokitz, Bradley Steward, Morrell-Falvey, Jennifer L., Salazar, Juan Pablo Hinestrosa, Messman, Jamie Michael, Kilbey, II, Sidney Michael, and Ankner, John Francis. Bioactive compositions for high avidity cell capture. United States: N. p., 2018. Web.
Hansen, Ryan Robert, Retterer, Scott T., Lokitz, Bradley Steward, Morrell-Falvey, Jennifer L., Salazar, Juan Pablo Hinestrosa, Messman, Jamie Michael, Kilbey, II, Sidney Michael, & Ankner, John Francis. Bioactive compositions for high avidity cell capture. United States.
Hansen, Ryan Robert, Retterer, Scott T., Lokitz, Bradley Steward, Morrell-Falvey, Jennifer L., Salazar, Juan Pablo Hinestrosa, Messman, Jamie Michael, Kilbey, II, Sidney Michael, and Ankner, John Francis. Tue . "Bioactive compositions for high avidity cell capture". United States. https://www.osti.gov/servlets/purl/1494583.
@article{osti_1494583,
title = {Bioactive compositions for high avidity cell capture},
author = {Hansen, Ryan Robert and Retterer, Scott T. and Lokitz, Bradley Steward and Morrell-Falvey, Jennifer L. and Salazar, Juan Pablo Hinestrosa and Messman, Jamie Michael and Kilbey, II, Sidney Michael and Ankner, John Francis},
abstractNote = {A composition useful for cell capture, the composition comprising a solid substrate on which is affixed a patterned polymer, and a cell-targeting agent attached to said patterned polymer, wherein said cell-targeting agent is exposed. Also described is a method for the preparation of the cell capturing composition, as well as flow through devices in which the cell capturing composition is incorporated. Further described is a method of capturing cells by contacting the cell-capturing composition with a liquid or gaseous sample containing cells. The method for capturing cells may also be a method for testing for the presence of one or more classes or species of cells or cellular organisms in a liquid or gaseous sample.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {11}
}

Patent:

Save / Share:

Works referenced in this record:

Ring-opening metathesis polymerization-derived, lectin-functionalized monolithic supports for affinity separation of glycoproteins: Liquid Chromatography
journal, March 2013


Nano/Microscale Order Affects the Early Stages of Biofilm Formation on Metal Surfaces
journal, October 2007


Tailored Silicon Nanopost Arrays for Resonant Nanophotonic Ion Production
journal, February 2010


Lectin-Functionalized Poly(glycidyl methacrylate)- block -poly(vinyldimethyl azlactone) Surface Scaffolds for High Avidity Microbial Capture
journal, September 2013


Fabricating three-dimensional carbohydrate hydrogel microarray for lectin-mediated bacterium capturing
journal, August 2014


Submicron Trenches Reduce the Pseudomonas fluorescens Colonization Rate on Solid Surfaces
journal, January 2009

  • Díaz, Carolina; Schilardi, Patricia L.; dos Santos Claro, Paula C.
  • ACS Applied Materials & Interfaces, Vol. 1, Issue 1, p. 136-143
  • https://doi.org/10.1021/am8000677

Synthetic polymers for capture and detection of microorganisms
journal, January 2007


Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms
journal, May 2013


Novel temperature-responsive polymer brushes with carbohydrate residues facilitate selective adhesion and collection of hepatocytes
journal, December 2012


Hierarchically imprinted polymer substrates for enhanced attachment of Escherichia coli
journal, March 2010


Nanopatterned Smart Polymer Surfaces for Controlled Attachment, Killing, and Release of Bacteria
journal, September 2013


Protein Immobilization Strategies for Protein Biochips
journal, June 2007


Well-Defined Azlactone-Functionalized (Co)polymers on a Solid Support:  Synthesis via Supported Living Radical Polymerization and Application as Nucleophile Scavengers
journal, July 2006


Microstructured Block Copolymer Surfaces for Control of Microbe Adhesion and Aggregation
journal, March 2014