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Title: Bioactive compositions for high avidity cell capture

A composition useful for cell capture, the composition comprising a solid substrate on which is affixed a patterned polymer, and a cell-targeting agent attached to said patterned polymer, wherein said cell-targeting agent is exposed. Also described is a method for the preparation of the cell capturing composition, as well as flow through devices in which the cell capturing composition is incorporated. Further described is a method of capturing cells by contacting the cell-capturing composition with a liquid or gaseous sample containing cells. The method for capturing cells may also be a method for testing for the presence of one or more classes or species of cells or cellular organisms in a liquid or gaseous sample.
Inventors:
; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1494583
Assignee:
UT-BATTELLE, LLC (Oak Ridge, TN) ORNL
Patent Number(s):
10,131,899
Application Number:
14/215,552
Contract Number:
AC05-00OR22725
Resource Relation:
Patent File Date: 2014 Mar 17
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES