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Title: Techniques for controlling distance between a sample and sample probe while such probe liberates analyte from a sample region for analysis with a mass spectrometer

Abstract

A system includes a mass spectrometer and associated sample interfacing equipment. The sample interfacing equipment includes a platform structured to support a sample thereon, a fluid source, a high voltage source, a dispensing probe electrically coupled to the high voltage source and defining a fluid dispensing passage therethrough, a collection probe defining a collection passage therethrough, a sensing arrangement coupled to the dispensing probe, and control logic responsive to the sensing arrangement to control distance between the dispensing probe and the sample. The dispensing probe facilitates formation of one or more ionized sample analytes when dispensing the fluid through the dispensing passage proximate to the sample on the platform. The collecting probe receives at least some of the one or more ionized sample analytes to pass through the collection passage into the mass spectrometer for analysis.

Inventors:
; ;
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1494300
Patent Number(s):
10,134,572
Application Number:
15/225,585
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Aug 01
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Laskin, Julia, Nguyen, Son N., and Liyu, Andrey V. Techniques for controlling distance between a sample and sample probe while such probe liberates analyte from a sample region for analysis with a mass spectrometer. United States: N. p., 2018. Web.
Laskin, Julia, Nguyen, Son N., & Liyu, Andrey V. Techniques for controlling distance between a sample and sample probe while such probe liberates analyte from a sample region for analysis with a mass spectrometer. United States.
Laskin, Julia, Nguyen, Son N., and Liyu, Andrey V. Tue . "Techniques for controlling distance between a sample and sample probe while such probe liberates analyte from a sample region for analysis with a mass spectrometer". United States. https://www.osti.gov/servlets/purl/1494300.
@article{osti_1494300,
title = {Techniques for controlling distance between a sample and sample probe while such probe liberates analyte from a sample region for analysis with a mass spectrometer},
author = {Laskin, Julia and Nguyen, Son N. and Liyu, Andrey V.},
abstractNote = {A system includes a mass spectrometer and associated sample interfacing equipment. The sample interfacing equipment includes a platform structured to support a sample thereon, a fluid source, a high voltage source, a dispensing probe electrically coupled to the high voltage source and defining a fluid dispensing passage therethrough, a collection probe defining a collection passage therethrough, a sensing arrangement coupled to the dispensing probe, and control logic responsive to the sensing arrangement to control distance between the dispensing probe and the sample. The dispensing probe facilitates formation of one or more ionized sample analytes when dispensing the fluid through the dispensing passage proximate to the sample on the platform. The collecting probe receives at least some of the one or more ionized sample analytes to pass through the collection passage into the mass spectrometer for analysis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {11}
}

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Works referenced in this record:

Ambient mass spectrometry for in vivo local analysis and in situ molecular tissue imaging
journal, April 2012


Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
journal, October 2004