Title: Techniques for controlling distance between a sample and sample probe while such probe liberates analyte from a sample region for analysis with a mass spectrometer

Abstract

A system includes a mass spectrometer and associated sample interfacing equipment. The sample interfacing equipment includes a platform structured to support a sample thereon, a fluid source, a high voltage source, a dispensing probe electrically coupled to the high voltage source and defining a fluid dispensing passage therethrough, a collection probe defining a collection passage therethrough, a sensing arrangement coupled to the dispensing probe, and control logic responsive to the sensing arrangement to control distance between the dispensing probe and the sample. The dispensing probe facilitates formation of one or more ionized sample analytes when dispensing the fluid through the dispensing passage proximate to the sample on the platform. The collecting probe receives at least some of the one or more ionized sample analytes to pass through the collection passage into the mass spectrometer for analysis.

Inventors:

Laskin, Julia; Nguyen, Son N.; Liyu, Andrey V.

Issue Date:

2018-11-20

Research Org.:

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1494300

Patent Number(s):

10134572

Application Number:

15/225,585

Assignee:

Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

H01J49/0004 - {Imaging particle spectrometry}
H01J49/0027 - {Methods for using particle spectrometers}
H01J49/0409 - {Sample holders or containers
H01J49/0459 - {for solid samples}

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DOE Contract Number:  

AC05-76RL01830

Resource Type:

Patent

Resource Relation:

Patent File Date: 2016 Aug 01

Country of Publication:

United States

Language:

English

Subject:

47 OTHER INSTRUMENTATION