Amplification of biological targets via on-chip culture for biosensing
Abstract
The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1493615
- Patent Number(s):
- 10,126,299
- Application Number:
- 15/820,836
- Assignee:
- National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
- DOE Contract Number:
- NA0003525
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2017 Nov 22
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Harper, Jason C., Edwards, Thayne L., Carson, Bryan, Finley, Melissa, and Arndt, William. Amplification of biological targets via on-chip culture for biosensing. United States: N. p., 2018.
Web.
Harper, Jason C., Edwards, Thayne L., Carson, Bryan, Finley, Melissa, & Arndt, William. Amplification of biological targets via on-chip culture for biosensing. United States.
Harper, Jason C., Edwards, Thayne L., Carson, Bryan, Finley, Melissa, and Arndt, William. Tue .
"Amplification of biological targets via on-chip culture for biosensing". United States. https://www.osti.gov/servlets/purl/1493615.
@article{osti_1493615,
title = {Amplification of biological targets via on-chip culture for biosensing},
author = {Harper, Jason C. and Edwards, Thayne L. and Carson, Bryan and Finley, Melissa and Arndt, William},
abstractNote = {The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {11}
}
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Works referenced in this record:
Stabilization of Peracid Solutions
patent, April 1944
- Reichert, Joseph S.; McNeight, Samuel A.; Elston, Arthur A.
- US Patent Document 2,347,434
Stabilization of Dilute Solutions of Aliphatic Acids
patent, April 1952
- Greenspan, Frank P.; MacKellar, Donald G.
- US Patent Document 2,590,856
Stabilization of Peracids with Dipicolinic Acid
patent, September 1952
- Greenspan, Frank P.; MacKellar, Donald G.
- US Patent Document 2,609,391
Stable peroxy-containing microbicides
patent, September 1977
- Bowing, Walter; Mrozek, Hinrich; Schlussler, Hans-Joachim
- US Patent Document 4,051,058
Stable, shippable, peroxy-containing microbicide
patent, August 1997
- Cosentino, Louis; Hnojewyj, Anatol; Fischbach, Leroy
- US Patent Document 5,656,302
Fluorogenic compounds
patent, April 2002
- Bentsen, James; Mickelson, Christopher; Knudson, Orlin
- US Patent Document 6,372,895
Fluorogenic compounds and uses therefor
patent, May 2003
- Bentsen, James; Mickelson, Christopher; Knudson, Orlin
- US Patent Document 6,566,508
Microwell cell-culture device and fabrication method
patent, September 2012
- Hung, Paul Ju-Sung; Lee, Philip
- US Patent Document 8,257,964
Methods for the detection, analysis and isolation of nascent proteins
patent, October 2012
- Rothschild, Kenneth; Gite, Sadanand; Olejnik, Jerzy
- US Patent Document 8,278,045
Laser Machined Plastic Laminates: Towards Portable Diagnostic Devices for Use in Low Resource Environments
journal, July 2015
- Harper, Jason C.; Carson, Bryan D.; Bachand, George D.
- Electroanalysis, Vol. 27, Issue 11, p. 2503-2512
Magnetic-adhesive based valves for microfluidic devices used in low-resource settings
journal, January 2016
- Harper, Jason C.; Andrews, Jenna M.; Ben, Candice
- Lab on a Chip, Vol. 16, Issue 21, p. 4142-4151
Point-of-care nucleic acid testing for infectious diseases
journal, May 2011
- Niemz, Angelika; Ferguson, Tanya M.; Boyle, David S.
- Trends in Biotechnology, Vol. 29, Issue 5, p. 240-250
Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008
- Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
- Biosensors and Bioelectronics, Vol. 23, Issue 6, p. 757-764
Selective Immobilization of DNA and Antibody Probes on Electrode Arrays: Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform
journal, July 2007
- Harper, Jason C.; Polsky, Ronen; Wheeler, David R.
- Langmuir, Vol. 23, Issue 16, p. 8285-8287