Amplification of biological targets via on-chip culture for biosensing

Title: Amplification of biological targets via on-chip culture for biosensing

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Inventors:: Harper, Jason C.; Edwards, Thayne L.; Carson, Bryan; Finley, Melissa; Arndt, William

Issue Date:: 2018-11-13

OSTI Identifier:: 1493615

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM) SNL

Patent Number(s):: 10,126,299

Application Number:: 15/820,836

Contract Number:: NA0003525

Resource Relation:: Patent File Date: 2017 Nov 22

Research Org:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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