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Title: Method for producing 3-hydroxypropionic acid and other products

Abstract

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.

Inventors:
; ;
Issue Date:
Research Org.:
Cargill, Incorporated, Wayzata, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1489753
Patent Number(s):
10,100,342
Application Number:
15/167,439
Assignee:
Cargill, Incorporated (Wayzata, MN)
DOE Contract Number:  
AR0000088
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 May 27
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Lynch, Michael D., Gill, Ryan T., and Lipscomb, Tanya E. W. Method for producing 3-hydroxypropionic acid and other products. United States: N. p., 2018. Web.
Lynch, Michael D., Gill, Ryan T., & Lipscomb, Tanya E. W. Method for producing 3-hydroxypropionic acid and other products. United States.
Lynch, Michael D., Gill, Ryan T., and Lipscomb, Tanya E. W. Tue . "Method for producing 3-hydroxypropionic acid and other products". United States. https://www.osti.gov/servlets/purl/1489753.
@article{osti_1489753,
title = {Method for producing 3-hydroxypropionic acid and other products},
author = {Lynch, Michael D. and Gill, Ryan T. and Lipscomb, Tanya E. W.},
abstractNote = {This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {10}
}

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  • Zha, Wenjuan; Rubin-Pitel, Sheryl B.; Shao, Zengyi
  • Metabolic Engineering, Vol. 11, Issue 3, p. 192-198
  • DOI: 10.1016/j.ymben.2009.01.005

Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2
journal, January 2005

  • Zhao, B.; Guengerich, F. P.; Bellamine, A.
  • Journal of Biological Chemistry, Vol. 280, Issue 12
  • DOI: 10.1074/jbc.M410933200

Interdomain Communication between the Thiolation and Thioesterase Domains of EntF Explored by Combinatorial Mutagenesis and Selection
journal, August 2006


Control Mechanisms in the Synthesis of Saturated Fatty Acids
journal, June 1977


A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis
journal, August 2004

  • Bonner, Carol A.; Jensen, Roy A.; Gander, John E.
  • Biochemical Journal, Vol. 382, Issue 1
  • DOI: 10.1042/BJ20031809

Selective production of L-aspartic acid and L-phenylalanine by coupling reactions of aspartase and aminotransferase in Escherichia coli
journal, July 2000


Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and characterization of a new isochorismate synthase from Escherichia coli.
journal, May 1997


FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli
journal, November 2003


The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase
journal, January 1996


Characterization of two temperature-inducible promoters newly isolated from B. subtilis
journal, July 2007

  • Li, Wang; Li, Heng-Xin; Ji, Sheng-Yue
  • Biochemical and Biophysical Research Communications, Vol. 358, Issue 4, p. 1148-1153
  • DOI: 10.1016/j.bbrc.2007.05.064

Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase.
journal, August 1992


Sequence and overexpression of the menD gene from Escherichia coli.
journal, August 1989


Overexpression, Purification, and Characterization of Tyrosine-Sensitive 3-Deoxy-d-arabino-heptulosonic Acid 7-Phosphate Synthase fromEscherichia coli
journal, March 1997

  • Ramilo, Cecilia A.; Evans, Jeremy N. S.
  • Protein Expression and Purification, Vol. 9, Issue 2
  • DOI: 10.1006/prep.1996.0690

Development and evaluation of efficient recombinant Escherichia coli strains for the production of 3-hydroxypropionic acid from glycerol
journal, January 2009

  • Rathnasingh, Chelladurai; Raj, Subramanian Mohan; Jo, Ji-Eun
  • Biotechnology and Bioengineering, Vol. 104, Issue 4, p. 729-739
  • DOI: 10.1002/bit.22429

Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity
journal, July 2002


Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
journal, December 2002

  • Welch, R. A.; Burland, V.; Plunkett, G.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 26, p. 17020-17024
  • DOI: 10.1073/pnas.252529799

Inhibiting Bacterial Fatty Acid Synthesis
journal, April 2006

  • Zhang, Yong-Mei; White, Stephen W.; Rock, Charles O.
  • Journal of Biological Chemistry, Vol. 281, Issue 26
  • DOI: 10.1074/jbc.R600004200