skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method for producing 3-hydroxypropionic acid and other products


This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.

; ;
Issue Date:
Research Org.:
Cargill, Incorporated, Wayzata, MN (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Cargill, Incorporated (Wayzata, MN)
Patent Classifications (CPCs):
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 2016 May 27
Country of Publication:
United States

Citation Formats

Lynch, Michael D., Gill, Ryan T., and Lipscomb, Tanya E. W. Method for producing 3-hydroxypropionic acid and other products. United States: N. p., 2018. Web.
Lynch, Michael D., Gill, Ryan T., & Lipscomb, Tanya E. W. Method for producing 3-hydroxypropionic acid and other products. United States.
Lynch, Michael D., Gill, Ryan T., and Lipscomb, Tanya E. W. Tue . "Method for producing 3-hydroxypropionic acid and other products". United States.
title = {Method for producing 3-hydroxypropionic acid and other products},
author = {Lynch, Michael D. and Gill, Ryan T. and Lipscomb, Tanya E. W.},
abstractNote = {This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {10}


Save / Share:

Works referenced in this record:

The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase
journal, September 1986

Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine
journal, September 1999

Engineering Central Metabolic Pathways for High-Level Flavonoid Production in Escherichia coli
journal, April 2007

Developments in Directed Evolution for Improving Enzyme Functions
journal, August 2007

Metabolic engineering of aromatic group amino acid pathway in Bacillus subtilis for L-phenylalanine production
journal, November 2004

Induction of specific base-pair substitutions in E. coli trpA mutants by chloroenthylene oxide, a carcinogenic vinyl chloride metabolite
journal, November 1985

Sequence and overexpression of the menD gene from Escherichia coli.
journal, August 1989

Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
journal, October 2004

Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria
journal, January 2007

Role of bicarbonate/CO2 in the inhibition of Escherichia coli growth by cyanate.
journal, June 1995

A mild and efficient method for esterification and transesterification catalyzed by iodine
journal, January 2002

Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of α-ketoglutarate decarboxylase
journal, July 2005

Interdomain Communication between the Thiolation and Thioesterase Domains of EntF Explored by Combinatorial Mutagenesis and Selection
journal, August 2006

Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using coupled transaminase reactions
journal, January 2003

Expression of proteins encoded by the Escherichia coli cyn operon: carbon dioxide-enhanced degradation of carbonic anhydrase.
journal, September 1994

Engineering primary metabolic pathways of industrial micro-organisms
journal, March 2007

Effect of poxB gene knockout on metabolism in Escherichia coli based on growth characteristics and enzyme activities
journal, September 2006

The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase
journal, January 1996

Effect of process parameters on 3-hydroxypropionic acid production from glycerol using a recombinant Escherichia coli
journal, April 2009

A genomics approach to improve the analysis and design of strain selections
journal, May 2008

Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase.
journal, August 1992

CHEMISTRY: Sugary Recipe Boosts Grow-Your-Own Plastics
journal, June 2006

Structure of Cellulases and Their Applications
journal, April 1997

Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering
journal, May 2009

Engineering of a functional human NADH-dependent cytochrome P450 system
journal, January 2001

A new perspective on thiamine catalysis
journal, August 2004

Effect of Overexpression of Actinobacillus succinogenes Phosphoenolpyruvate Carboxykinase on Succinate Production in Escherichia coli
journal, February 2004

The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems
journal, April 2010

Fe2(SO4)3·4H2O/concentrated H2SO4: an efficient catalyst for esterification
journal, March 2004

Polyphosphate Kinase Protects Salmonella enterica from Weak Organic Acid Stress
journal, April 2005

Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different
journal, April 2001

Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer
journal, October 2007

A new preparation of trifluoromethanesulfinate salts
journal, July 2007

Extractive recovery of products from fermentation broths
journal, April 1999

The IdhA Gene Encoding the Fermentative Lactate Dehydrogenase of Escherichia Coli
journal, January 1997

Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH.
journal, April 1992

Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase
journal, January 1988

Structure−Cytoprotective Activity Relationship of Simple Molecules Containing an α,β-Unsaturated Carbonyl System
journal, June 1997

Characterization of two temperature-inducible promoters newly isolated from B. subtilis
journal, July 2007

Polypeptide Release Factors in Prokaryotes and Eukaryotes
journal, January 2002

Cloning, crystallization and preliminary characterization of a β-carbonic anhydrase from Escherichia coli
journal, September 2000

Network rigidity and metabolic engineering in metabolite overproduction
journal, June 1991

On the Role of Helix 0 of the Tryptophan Synthetase α Chain of Escherichia coli
journal, June 1996

The commercial production of chemicals using pathway engineering
journal, December 2000

Selective production of L-aspartic acid and L-phenylalanine by coupling reactions of aspartase and aminotransferase in Escherichia coli
journal, July 2000

Molecular breeding of carotenoid biosynthetic pathways
journal, July 2000

Genes restoring redox balance in fermentation-deficient E. coli NZN111
journal, November 2009

Reactions of β-lactones with potassium alkoxides and their complexes with 18-crown-6 in aprotic solvents
journal, July 1993

?-hydroxypropionic acid production by Byssochlamys sp. grown on acrylic acid
journal, November 1993

FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli
journal, November 2003

Cloning and Overexpression in Soluble Form of Functional Shikimate Kinase and 5-Enolpyruvylshikimate 3-Phosphate Synthase Enzymes from Mycobacterium tuberculosis
journal, August 2001

Fermentation of Glucose to Lactic Acid Coupled with Reactive Extraction:  A Review
journal, September 2004

Biosynthetic pathways for 3-hydroxypropionic acid production
journal, February 2009

A T42M Substitution in Bacterial 5-Enolpyruvylshikimate-3-phosphate Synthase (EPSPS) Generates Enzymes with Increased Resistance to Glyphosate
journal, January 2003

A novel methodology employing Corynebacterium glutamicum genome information to generate a new L -lysine-producing mutant
journal, January 2002

Identification of PhoB binding sites of the yibD and ytfK promoter regions in Escherichia coli
journal, April 2011

Overproduction of phage Lambda repressor under control of the lac promotor of Escherichia coli
journal, January 1976

Naturally Occurring Adenines within mRNA Coding Sequences Affect Ribosome Binding and Expression in Escherichia coli
journal, November 2006

A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis
journal, August 2004

Genetic Evidence for an Interaction of the UbiG O-Methyltransferase with UbiX in Escherichia coli Coenzyme Q Biosynthesis
journal, August 2006

Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design
journal, August 2005

Purification and characterization of 2-oxoglutarate decarboxylase of Leuconostoc oenos
journal, August 1990

Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis
journal, May 2003

Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway
journal, June 2010

Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes
journal, May 2010

A New Enzymatic Method of Acrylamide Production
journal, May 1982

Switch of coenzyme specificity of p -hydroxybenzoate hydroxylase 1 1Edited by A. R. Fersht
journal, September 1999

Characterization of the major promoter for the plasmid-encoded sucrose genes scrY, scrA, and scrB.
journal, December 1991

Synthesis of labeled acrylamide andN-methylolacrylamide (NMA):15N-acrylamide,13C-NMA,15N-NMA, and13C,15N-NMA
journal, January 2005

Application of Functional Genomics to Pathway Optimization for Increased Isoprenoid Production
journal, March 2008

The tyrosine repressor negatively regulates aroH expression in Escherichia coli.
journal, June 1991

Method for purifying lactic acid
patent, December 2002

Identification and cloning of the Mycobacterium avium folA gene, required for dihydrofolate reductase activity
journal, November 1997

A Single Mutation Converts a Novel Phosphotyrosine Binding Domain into a Dual-specificity Phosphatase
journal, November 1995

A Physiology Study of Escherichia coli Overexpressing Phosphoenolpyruvate Carboxykinase
journal, April 2008

Sequences of the envM gene and of two mutated alleles in Escherichia coli
journal, October 1992

A Novel Quinone-forming Monooxygenase Family Involved in Modification of Aromatic Polyketides
journal, February 2005

Structure of the EntB Multidomain Nonribosomal Peptide Synthetase and Functional Analysis of Its Interaction with the EntE Adenylation Domain
journal, April 2006

Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2
journal, January 2005

Genome-wide screening for trait conferring genes using DNA microarrays
journal, May 2002