Synthetic methylotrophy to liquid fuels and chemicals
Abstract
A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Delaware, Newark, DE (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1477456
- Patent Number(s):
- 10,059,920
- Application Number:
- 15/112,364
- Assignee:
- University of Delaware (Newark, DE)
- DOE Contract Number:
- AR0000432
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Jan 09
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, and Antoniewicz, Maciek. Synthetic methylotrophy to liquid fuels and chemicals. United States: N. p., 2018.
Web.
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, & Antoniewicz, Maciek. Synthetic methylotrophy to liquid fuels and chemicals. United States.
Papoutsakis, Eleftherios T., Nicolaou, Sergios, Fast, Alan, Falara, Vasiliki, Bennett, Robert Kyle, Whitaker, William Brian, Sandoval, Nicholas Richard, Gonzalez, Jacqueline, and Antoniewicz, Maciek. Tue .
"Synthetic methylotrophy to liquid fuels and chemicals". United States. https://www.osti.gov/servlets/purl/1477456.
@article{osti_1477456,
title = {Synthetic methylotrophy to liquid fuels and chemicals},
author = {Papoutsakis, Eleftherios T. and Nicolaou, Sergios and Fast, Alan and Falara, Vasiliki and Bennett, Robert Kyle and Whitaker, William Brian and Sandoval, Nicholas Richard and Gonzalez, Jacqueline and Antoniewicz, Maciek},
abstractNote = {A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {8}
}
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