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  • Synthetic methylotrophy to liquid fuels and chemicals

Title: Synthetic methylotrophy to liquid fuels and chemicals

A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.
Inventors:
; ; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1477456
Assignee:
University of Delaware (Newark, DE) ARPA-E
Patent Number(s):
10,059,920
Application Number:
15/112,364
Contract Number:
AR0000432
Resource Relation:
Patent File Date: 2015 Jan 09
Research Org:
Univ. of Delaware, Newark, DE (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Works referenced in this record:

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Bifunctional enzyme fusion of 3-hexulose-6-phosphate synthase and 6-phospho-3-hexuloisomerase
journal, May 2007
  • Orita, Izumi; Sakamoto, Naoki; Kato, Nobuo
  • Applied Microbiology and Biotechnology, Vol. 76, Issue 2, p. 439-445
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