Systems, devices, and methods for agglutination assays using sedimentation

Schaff, Ulrich Y.; Sommer, Gregory Jon; Singh, Anup K.

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Title: Systems, devices, and methods for agglutination assays using sedimentation

Abstract

Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.

Inventors:: Schaff, Ulrich Y.; Sommer, Gregory Jon; Singh, Anup K.

Issue Date:: 2018-07-17

Research Org.:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1465194

Patent Number(s):: 10024849

Application Number:: 14/853,660

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D21/262 - {by using a centrifuge}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2200/0631 - Purification arrangements, e.g. solid phase extraction [SPE]
B01L2200/0647 - Handling flowable solids, e.g. microscopic beads, cells, particles
B01L2200/10 - Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
B01L2300/0627 - Sensor or part of a sensor is integrated
B01L2300/0803 - Disc shape
B01L2300/0861 - Configuration of multiple channels and/or chambers in a single devices
B01L2400/0409 - centrifugal forces
B01L2400/0457 - passive flow or gravitation
B01L3/5021 - {Test tubes specially adapted for centrifugation purposes
B01L3/50215 - {using a float to separate phases}
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/502738 - {characterised by integrated valves
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
B01L3/502761 - {specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/537 - with separation of immune complex from unbound antigen or antibody
G01N33/538 - by sorbent column, particles or resin strip {, i.e. sorbent materials}
G01N33/543 - with an insoluble carrier for immobilising immunochemicals
G01N33/54313 - {the carrier being characterised by its particulate form}
G01N33/54366 - {Apparatus specially adapted for solid-phase testing}

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Sep 14

Country of Publication:: United States

Language:: English

Citation Formats


                    Schaff, Ulrich Y., Sommer, Gregory Jon, and Singh, Anup K. Systems, devices, and methods for agglutination assays using sedimentation.  United States: N. p., 2018. 
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                    Schaff, Ulrich Y., Sommer, Gregory Jon, & Singh, Anup K. Systems, devices, and methods for agglutination assays using sedimentation.  United States.

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                    Schaff, Ulrich Y., Sommer, Gregory Jon, and Singh, Anup K. Tue .  
        "Systems, devices, and methods for agglutination assays using sedimentation".  United States.  https://www.osti.gov/servlets/purl/1465194.

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@article{osti_1465194,

  title        = {Systems, devices, and methods for agglutination assays using sedimentation},

  author       = {Schaff, Ulrich Y. and Sommer, Gregory Jon and Singh, Anup K.},

  abstractNote = {Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2018},

  month        = {7}

}

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Similar Records

Title: Systems, devices, and methods for agglutination assays using sedimentation

Abstract

Citation Formats

Fully Integrated Lab-on-a-Disc for Nucleic Acid Analysis of Food-Borne Pathogens journal, March 2014

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Capillary columns with in situ formed porous monolithic packing for micro high-performance liquid chromatography and capillary electrochromatography journal, September 1999

Detection of Listeria monocytogenes and the toxin listeriolysin O in food journal, February 2006

Design Strategies and Performance of Custom DNA Sequencing Primers journal, September 1999

Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay patent, June 1997

Protecting agent patent-application, August 2005

Microfluidic particle-analysis systems patent-application, April 2004

Experimental optimization of probe length to increase the sequence specificity of high-density oligonucleotide microarrays journal, January 2007

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent, November 2001

Systems and Methods for Handling Microfluidic Droplets patent-application, October 2013

Multi-parameter assays including analysis discs and methods relating thereto patent-application, October 2002

Centrifugal Microfluidic Platform for Ultrasensitive Detection of Botulinum Toxin journal, December 2014

Centrifugation Apparatus For Containers Of Biological Material patent-application, February 2011

Loading Disk for Photometric Analyzer of Rotary Cuvette Type patent, July 1973

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids patent, February 2008

Fully Integrated Lab-on-a-Disc for Nucleic Acid Analysis of Food-Borne Pathogens
journal, March 2014

Apparatus and method for carrying out analysis of samples
patent, April 1999

Diagnostic Analyzers With Pretreatment Carousels and Related Methods
patent-application, September 2014

Microfluidics devices and methods for performing cell based assays
patent-application, August 2002

Capillary columns with in situ formed porous monolithic packing for micro high-performance liquid chromatography and capillary electrochromatography
journal, September 1999

Detection of Listeria monocytogenes and the toxin listeriolysin O in food
journal, February 2006

Design Strategies and Performance of Custom DNA Sequencing Primers
journal, September 1999

Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
patent, June 1997

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Microfluidic particle-analysis systems
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Experimental optimization of probe length to increase the sequence specificity of high-density oligonucleotide microarrays
journal, January 2007

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
patent, November 2001

Systems and Methods for Handling Microfluidic Droplets
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Multi-parameter assays including analysis discs and methods relating thereto
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Centrifugal Microfluidic Platform for Ultrasensitive Detection of Botulinum Toxin
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